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Fig. 5 | Cancer Cell International

Fig. 5

From: Glioblastoma cells have increased capacity to repair radiation-induced DNA damage after migration to the olfactory bulb

Fig. 5

SAC related gene expression in tumor cells. A IPA defined subfunctions of the Cell cycle molecular function enriched in OB versus RH (all had p-values < 6.05E–08). Highlighted in blue are categories related to Mitosis. B Top GO terms in OB versus RH as defined by Normalized Enrichment Score (NES). C Kaplan–Meier analyses comparing overall survival of GBM patients versus expression of SAC and NHEJ related genes overexpressed in OB. D Representative matched images of SAC related proteins in NSC11 and NSC20 tumor cells in OB and RH. (DAPI, Sox2 and proteins of interest are shown in blue, green and red, respectively). E SAC protein expression was determined by fluorescent intensity (CTCF fold change) in NSC11 and NSC20 tumor cells in OB vs. RH. Each point corresponds to an individual mouse with at least 100 cells analyzed in each location with lines connecting the matched OB (white circle) and RH (black circle) from the same mouse. Values represent the mean ± SEM, n = 3–5. *p-val < 0.05

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Cancer Cell International

ISSN: 1475-2867

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