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Fig. 7 | Cancer Cell International

Fig. 7

From: CD5L-associated gene analyses highlight the dysregulations, prognostic effects, immune associations, and drug-sensitivity predicative potentials of LCAT and CDC20 in hepatocellular carcinoma

Fig. 7

The correlations of CD5L, LCAT and CDC20 with immunoregulators. A The significant correlations of CD5L with 18 immunoinhibitors, 18 immunostimulators and 11 MHC-related genes in HCC. B–C The significant positive correlations of CD5L with CD244, PDCD1LG2, CD274 (Programmed death ligand 1, PD-L1) while negative correlation with CD276 (B7-H3) in TCGA-HCC and ICGC-HCC, respectively. D The significant correlations of LCAT with four immunoinhibitors, ten immunostimulators and five MHC-related genes in HCC. E–F The positive correlation of LCAT with CD244 while negative correlations with MICB, TAP1, and TNFRSF4 in TCGA-HCC and ICGC-HCC, respectively. G The significant correlations of CDC20 with 13 immunoinhibitors, 27 immunostimulators and 12 MHC-related genes in HCC. H–I The positive correlations of CDC20 with CD276, CTLA4, PDCD1, and TNFRSF4 TCGA-HCC and ICGC-HCC, respectively. PDCD1LG2, programmed cell death 1 ligand 2; MICB, MHC class I polypeptide-related sequence B; TAP1, transporter 1; TNFRSF4, TNF receptor superfamily member 4; CTLA4, cytotoxic T-lymphocyte associated protein 4. Spearman correlation analysis was used and p < 0.05 was considered significant

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Cancer Cell International

ISSN: 1475-2867

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