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Fig. 1 | Cancer Cell International

Fig. 1

From: Potential of Z-100, extracted from Mycobacterium tuberculosis strain Aoyama B, as a hot tumor inducer

Fig. 1

Antitumor effect of Z-100 in Sq-1979 model. a Schematic of the experimental design. Saline or Z-100 was administered subcutaneously into the right inguinal region of female C3H/HeN mice once daily for 49 days. On the 29th day of administration of saline or Z-100, Sq-1979 cells (1 × 106 cells) were injected subcutaneously into the right flank of the mice. Photographs of tumor model mice at 1 week after Sq-1979 cell injection (b) and at death (c). d Tumor growth in the Saline or Z-100 (0.01, 0.1, or 1 mg/kg)-administered groups (n = 20). Tumor growth was monitored by measuring tumor size (mm2) using a caliper. Data show mean ± SE; n = 20 per group. Asterisks indicate a significant difference compared with the Saline group; * P < 0.05, ** P < 0.01 and *** P < 0.001 (repeated measures ANOVA with Dunnett’s multiple comparisons test). e Tumor-bearing rate. f Survival rate in the Saline or 1 mg/kg Z-100-administered group (n = 40). Survival time of mice was recorded for up to 200 days after tumor injection and used to generate a survival curve. Asterisks indicate a significant difference compared with the Saline group; *** P < 0.001 (log-rank test)

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