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Fig. 5 | Cancer Cell International

Fig. 5

From: Potential of Z-100, extracted from Mycobacterium tuberculosis strain Aoyama B, as a hot tumor inducer

Fig. 5

Abolishment of the antitumor effects of Z-100 by anti-CD8 antibody. a Schematic of the experimental design. Saline or Z-100 (1 mg/kg) was administered subcutaneously into the right inguinal region of C3H/HeN female mice once daily for 49 days (n = 18–20). On the 29th day of saline or Z-100 administration, Sq-1979 cells (1 × 106 cells) were injected into the right flank. Moreover, control IgG (0.1 mg/body) or anti-CD8 antibody (0.1 mg/body) was administered intraperitoneally every 7 days from 3 days before cell injection until 46 days after cell injection. b Tumor growth in the Saline- or Z-100-administered group with antibody. Tumor growth was monitored by measuring tumor size (mm2) using a caliper. Data show mean ± SE. Asterisks indicate a significant difference compared with the Saline group; * P < 0.05 (repeated measures ANOVA). c Ratio of CD8+T/CD45+ in lymph nodes. Symbols indicate individual ratios and horizontal bars indicate mean ratios. NS, not significant (Student’s t-test)

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