Fig. 6From: Oleic acid from cancer-associated fibroblast promotes cancer cell stemness by stearoyl-CoA desaturase under glucose-deficient conditionSCD promotes tumorigenesis with nuclear localization of YAP. A Size of xenografted tumor following injection of parental, SCD-KO, and SCD-pCDH H460 cells. **P < 0.01 and ***P < 0.001. Data indicate the mean ± SEM (n = 3). B Representative image of hematoxylin and eosin and oil red O staining in xenografted tumors from parental, SCD-KO, and SCD-pCDH H460 cells. 4 × and 40 × magnification. Black and blue arrows indicate mitotic cell and multi nucleolus, respectively. N: necrosis region. C Representative fluorescence image of YAP and DAPI staining in xenografted tumors from parental, SCD-KO, and SCD-pCDH H460 cells. 20 × magnification. Scale bar: 75 μm. Asterisk indicates co-localized YAP and DAPI. D Analysis of survival rate (OS, PFS and PPS) in patients with lung cancer (n = 1925, 982, and 344, respectively) or lung adenocarcinoma (n = 719, 461, and 125, respectively) based on SCD expression using Kaplan–Meier plot of follow-up for 200 months. The level of SCD expression is divided with a median cutoff value. E Representative IHC staining for SCD in normal lung tissue and lung adenocarcinoma tissue microarray. 5 × and 20 × magnification. F Representative IHC staining for SCD in stage IA, IIA, IIB, and IIIA lung adenocarcinoma tissue microarray. 5 × and 20 × magnificationBack to article page