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Fig. 3 | Cancer Cell International

Fig. 3

From: Re-evaluation of the myoepithelial cells roles in the breast cancer progression

Fig. 3

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Schematic demonstration of the tumour suppression roles exhibited by the myoepithelial cells: myoepithelial cells are arranged in an integrated ring making a solid fence separating the inner cellular environment away from the surrounding stroma. Myoepithelial cells producing proteins contributed to cellular polarity and organization, Laminin-1 and Desmosomes. Many proteinase inhibitors, ant-angiogenic factors, and growth suppressors are also produced by myoepithelial cells defining the anti-invasive and anti-proliferative capacities owned by this population. TSP-1 Thrombospondin-1, MEPI Myoepithelium-derived serine proteinase inhibitor, and TIMP-1 Tissue inhibitors of metalloproteinases.

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