Table 5 Diagnostic value of miR-206 in non-malignant diseases
From: Emerging roles and mechanisms of miR-206 in human disorders: a comprehensive review
Type of disease | Number of samples | Distinguish between | Area under curve | Sensitivity (%) | Specificity (%) | Ref. |
|---|---|---|---|---|---|---|
Alzheimer’s disease (AD) | 128 subjects with amnestic mild cognitive impairment (aMCI) who progressed to AD (aMCI-AD) and 330 subjects who maintained an aMCI (aMCI- aMCI) diagnosis | aMCI-AD subjects vs. aMCI- aMCI subjects | 0.95 | 95.3 | 77.8 | [60] |
24 olfactory epithelia of early dementia patients, 8 patients with significant depression and 9 cognitively healthy controls | Mild cognitive impairment group (CDR 0.5; n = 13) vs. all subjects CDR 1 group (n = 11) vs. all subjects | 0.942 0.976 | 87.5 90.9 | 94.1 93.3 | [61] | |
Duchene muscular dystrophy | 39 DMD patients and 36 healthy controls | DMD vs. healthy controls | 0.96 | 94 | 95 | [71] |
Muscular dystrophies | 48 patients with DMD, DM1, LGMD, LGMD2B, FSHD, BMD, and DMRV and healthy controls | BMD vs. healthy controls | 0.90 | – | – | [77] |