Fig. 4

Characterization and TME in different potential molecular subtypes. A The GBM patients (n = 585) were divided into 3 potential molecular subtypes (C1, C2 and C3) by using the ConsensusClusterPlus (CC). B Log-rank test for the C1 (151 cases), C2 (239 cases) and C3 (195 cases) cohorts (p = 0.0027). C The stemness index difference between the 3 subtypes. (D) The Sankey diagram is about the relationship between 3 subtypes, clinical typing, and cytosine-phosphate-guanine (CpG) island methylator phenotype (G-CIMP). E The regulatory role of cell senescence-associated genes on immunization checkpoint expression in GBM tumors. F The abundance of each TME-infiltrating cell in C1, C2, and C3 clusters. G The differences in stromal score ESTIMATE score and immune score between the 3 potential subgroups. GOBP H analyses and KEGG analyses I for cell senescence-associated genes