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Fig. 9 | Cancer Cell International

Fig. 9

From: Increased expression of miR-194-5p through the circPVRL3/miR-194-5p/SOCS2 axis promotes proliferation and metastasis in pancreatic ductal adenocarcinoma by activating the PI3K/AKT signaling pathway

Fig. 9

CircPVRL3 inhibits proliferation and migration through the miR-194-5p/SOCS2 axis in PDAC. A Transwell assays were performed to detect the effect of circPVRL3 on PDAC cell migration. Scale bar = 200 μm. B CCK-8 assay indicated the proliferation effect of circPVRL3 in PDAC cells. C CFPAC-1 cells were transduced with lentivirus to establish circPVRL3-overexpressing stable cells and injected subcutaneously in vivo. The effect of circPVRL3 was reversed by treatment with the miR-194-5p agomir. D, E The tumor volumes and weights were recorded (n = 5). F The key molecules of the PI3K/AKT signaling pathway and SOCS2 were detected by western blotting. G Schematic diagram showing how the circPVRL3/miR-194-5p/SOCS2 axis promotes PDAC by activating the PI3K/AKT signaling pathway. *p < 0.05; **p < 0.01; ***p < 0.001

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Cancer Cell International

ISSN: 1475-2867

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