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Fig. 14 | Cancer Cell International

Fig. 14

From: Knock down of TIMP-2 by siRNA and CRISPR/Cas9 mediates diverse cellular reprogramming of metastasis and chemosensitivity in ovarian cancer

Fig. 14

Proposed model of TIMP-2/MMP ratio that controls ovarian tumorigenesis and chemotherapy (PTX) sensitivity. The model proposes that the ratio of TIMP-2/MMPs may decide the fate of ovarian cancer cells. Ovarian cancer cells with a low TIMP-2/MMP ratio (less availability of TIMP-2 and more MMPs) as in the case of the gRNA1 cells, may generate aggressive EMT-induced tumours with a greater degree of tumour burden and metastasis. These aggressive tumour cells due to their inherent proteolytic nature remodel tumour ECM to facilitate metastasis and are naturally resistant to chemotherapy. On the other hand, when the TIMP-2/MMP ratio is higher (more availability of TIMP-2) as seen in the case of gRNA2 cells, TGFβ induced EMT is displayed, but the tumours are less aggressive, inflammatory but non-infiltrating and sensitive to chemotherapy

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