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Fig. 4 | Cancer Cell International

Fig. 4

From: Therapeutic effect of a MUC1-specific monoclonal antibody-drug conjugates against pancreatic cancer model

Fig. 4

HzMUC1-MMAE induces apoptosis in pancreatic cancer cells. A The Capan-2, CFPAC-1, SW1990, and hTERT-HPNE cells were treated with HzMUC1-MMAE (10, 20, 40 nM) or human IgG-MMAE (10, 20, 40 nM) for 72 h. The cells were stained with annexin V and propidium iodide, and analyzed by flow cytometry using NovoExpress software. B Quantification of the flow cytometry analysis data from (A). The mean values from three different experiments were presented. HzMUC1-MMAE group was compared with control group. Statistical analyses were performed using One-way ANOVA with Bonferroni’s multiple comparision test, *P < 0.05, ***P < 0.001, ****P < 0.0001

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