Fig. 6

HzMUC1-MMAE dramatically inhibits the growth of Capan-2 xenograft tumor. BALB/c nu/nu mice were subcutaneously injected with Capan-2 cells to induce tumor formation. Once the tumors reached 120 mm³ in volumes, PBS (n = 9) or HzMUC1-MMAE (5 mg/kg, n = 9) was intravenous injected into mice three times (once every 6-day). A HzMUC1-MMAE dosing scheme. B Body weights for each treatment group. C The growth of tumor volumes over the experimental period. D Images of isolated tumors from mice euthanized at the end of experimental period. E Tumor weights for each treatment group. Statistical analyses were performed using unpaired two-tailed Student’s t-test. ***P < 0.001, ****P < 0.0001, the HzMUC1-MMAE group was compared with that of PBS control group