Fig. 5

ccRCC CM metabolome changes. A Top altered CM metabolites analyzed by GC–MS (complete GC–MS data are shown in Additional file 2: Table S11). B Validation of GC–MS. C The expression of SLC16A4 lactate transporter in ccRCC cells. The plot shows results of qPCR validation of microarray data. The analyses were performed using conditioned media (A, B) or RNA (C) isolated from 3 independent biological experiments. Statistical analysis: One-way ANOVA with Dunnett's Multiple Comparison Test. *p < 0.05, **p < 0.01, ***p < 0.001