Skip to main content
Fig. 7 | Cancer Cell International

Fig. 7

From: NEDD8 promotes radioresistance via triggering autophagy formation and serves as a novel prognostic marker in oral squamous cell carcinoma

Fig. 7

The proposed mechanism for NEDD8-conferred radioresistance in OSCC. The elevation of intracellular NEDD8-mediated protein neddylation may suppress the capacity of the Akt/mTOR signaling axis to restrain the formation of autophagy and thereby desensitize OSCC cells to irradiation treatment. The inclusion of MLN4924 suppresses protein neddylation, rescues the inhibitory function of the Akt/mTOR pathway toward autophagy formation and ultimately restores cellular sensitivity to irradiation in radioresistant OSCC

Back to article page

Cancer Cell International

ISSN: 1475-2867

Contact us