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Table 1 Cox univariate and multivariate analyses under the condition of overall survival probability against NEDD8 mRNA expression levels and clinical confounders derived GSE42743 cohort with OSCC

From: NEDD8 promotes radioresistance via triggering autophagy formation and serves as a novel prognostic marker in oral squamous cell carcinoma

Overall survival (n = 74)

Variables

Crude HR (95% CI)

P

Adjusted HR (95% CI)

P

Age

 < 60

1

NA

1

NA

 ≥ 60

1.52 (0.82–2.79)

0.183

1.33 (0.65–2.70)

0.438

Gender

 Female

1

NA

1

NA

 Male

0.68 (0.34–1.36)

0.270

0.73 (0.34–1.57)

0.424

pT

 T1-T2

1

NA

1

NA

 T3-T4

1.75 (0.90–3.41)

0.100

0.97 (0.40–2.34)

0.943

pN

 N0

1

NA

1

NA

 N1-N2C

3.67 (1.73–7.80)

0.001

3.88 (1.07–14.0)

0.039

Ecs

 No

1

NA

1

NA

 Yes

1.98 (1.07–3.69)

0.030

0.74 (0.34–1.63)

0.458

Smoker

 Yes

1

NA

1

NA

 No

1.14 (0.54–2.40)

0.734

1.11 (0.48–2.57)

0.809

ajcc4

 1–2

1

NA

1

NA

 3–4

2.91 (1.21–7.02)

0.017

1.17 (0.23–6.06)

0.854

NEDD8 levels

 Low

1

NA

1

NA

 High

2.09 (1.03–4.02)

0.027

2.06 (1.03–4.13)

0.041