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Fig. 1 | Cancer Cell International

Fig. 1

From: Changes in calpain-2 expression during glioblastoma progression predisposes tumor cells to temozolomide resistance by minimizing DNA damage and p53-dependent apoptosis

Fig. 1

Proteome comparison of initial GBM and non-malignant brain (n = 5). a Schematic of the proteomic comparison. One iGBM sample was paired with one non-malignant brain sample. b Venn diagram showing the overlap of all identified and quantified proteins in each of the five non-patient matched pairs. c Partial least-squares discriminant analysis (PLS-DA) of the initial glioblastoma (GBM, blue dot) and control non-malignant brain (CTRL, yellow triangle) samples showing a clear separation. d Volcano plot presenting the upregulated (blue triangle) and downregulated (yellow triangle) proteins in iGBM (LIMMA). e Gene Ontology annotated biological processes upregulated in iGBM. f Gene Ontology annotated biological processes downregulated in iGBM

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