Fig. 3From: Paradoxical effects of statins on endothelial and cancer cells: the impact of concentrationsRole of Rho in angiogenesis in Endothelial cells. The activation of the Rho/ROCK pathway via induction of phosphatase activity of PTEN, which in turn inhibits the activation of Akt and via reducing the stability of eNOS mRNA abolishes the acute activation of angiogenesis by statins; however, this pathway induces all process involved in angiogenesis including endothelial (ES) migration, vascular permeability, extracellular matrix (ECM) degradation, endothelial cell (EC) proliferation, lumen formation, and inhibition of apoptosis; therefore in long term period, Rho/Rock pathway may increase angiogenesis by statinsBack to article page