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Fig. 8 | Cancer Cell International

Fig. 8

From: PCK1 activates oncogenic autophagy via down-regulation Serine phosphorylation of UBAP2L and antagonizes colorectal cancer growth

Fig. 8

PCK1-induced autophagy inhibits CRC cell growth via down-regulation of UBAP2L Ser 454 phosphorylation. A IHC analysis p-UBAP2L Ser 454, UBAP2L, ATG5, and P62 expression in the p-UBAP2L Ser 454 (A) tumor and control groups. BC P62, ATG5, and LC3B protein expression in PCK1-OE RKO (B) and PCK1-OE SW480 (C) cells transfected with Ser 454-Ctrl and Ser 454 (A) for 24, 48, and 72 h. D and E LC3B expression in Ser 454-Ctrl and Ser 454 (A) cells after treatment with rapamycin or BAF for 4 h. Actin was used as a control. *P < 0.05, **P < 0.01, and ***P < 0.001

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