Table 1 Univariate analysis of prognostic factors influencing disease free survival (DFS) in stage I–III CRC
Disease-free survival | ||||
|---|---|---|---|---|
Characteristics | HR | 95%CI | P | |
Gender | Female vs Male | 1.23 | 0.90–1.69 | 0.185 |
Age (year) | ≤ 50 vs > 50 | 0.81 | 0.52–1.27 | 0.36 |
Location | Right side colon vs Left side colon vs Rectum | 0.15 | ||
Mucin production | With vs Without | 1.18 | 0.75–1.85 | 0.47 |
Tumor differentiation | Poor vs Moderate/well | 1.46 | 1.0–2.13 | 0.052 |
Tumor diameter | ≤ 5 cm vs >5 cm | 1.49 | 1.10–2.03 | 0.011 |
Tumor stage | I + II vs III | 1.88 | 1.38–2.57 | 0.001 |
Bowel wall invasion (T) | T1 + T2 vs T3 + T4 | 1.04 | 0.71–1.55 | 0.84 |
Lymph node metastasis (N) | With vs Without | 1.88 | 1.38–2.57 | 0.001 |
Lymphovascular invasion | YES vs No | 1.25 | 0.89–1.75 | 0.201 |
Alcohol intake | Never vs Ever | 0.76 | 0.52–1.09 | 0.14 |
Smoking | Never vs Ever | 0.85 | 0.61–1.20 | 0.35 |
Cancer family history | Yes vs No | 1.29 | 0.83–2.00 | 0.26 |
Colorectal family history | Yes vs No | 1.19 | 0.64–2.21 | 0.59 |
MSI status | MSI vs MSS | 1.02 | 0.65–1.59 | 0.94 |
KRAS status | Mutation vs Wildtype | 1.12 | 0.83–1.53 | 0.46 |
PCK1 | Low vs High | 1.71 | 1.05–2.76 | 0.03 |