Table 3 Correlations between PCK1 expression and clinicopathological characteristics in patients with CRC (n = 491)
PCK1 expression | ||||
|---|---|---|---|---|
Characteristics | Number | High (%) | Low (%) | P |
Gender | ||||
Male | 299 | 35 (11.71%) | 264 (88.29%) | 0.26 |
Female | 192 | 18 (9.38%) | 174 (90.63%) | |
Age (year) | ||||
≤ 50 | 64 | 8 (12.5%) | 56 (87.5%) | 0.67 |
> 50 | 427 | 45 (10.54%) | 382 (89.46%) | |
Location | ||||
Right side colon | 112 | 15 (13.39%) | 97 (86.61%) | 0.53 |
Left side colon | 93 | 8 (8.6%) | 85 (91.4%) | |
Rectum | 286 | 30 (10.49%) | 256 (89.51%) | |
Mucin production | ||||
With | 46 | 6 (13.04%) | 40 (86.96%) | 0.48 |
Without | 425 | 47 (11.06%) | 378 (88.94%) | |
Tumor differentiation | ||||
Poor | 106 | 9 (8.49%) | 97 (91.51%) | 0.25 |
Moderate/well | 385 | 44 (11.43%) | 341 (88.57%) | |
Tumor diameter | ||||
≤ 5 cm | 269 | 38 (14.13%) | 231 (85.87%) | 0.009 |
>5 cm | 222 | 15 (6.76%) | 207 (93.24%) | |
Tumor stage | ||||
I + II | 288 | 24 (8.33%) | 264 (91.67%) | 0.062 |
III | 203 | 29 (14.29%) | 174 (85.71%) | |
Bowel wall invasion (T) | ||||
T1 + T2 | 91 | 21 (23.07%) | 70 (76.93%) | 0.002 |
T3 + T4 | 400 | 32 (8.00%) | 368 (92.00%) | |
Lymph node metastasis (N) | ||||
Without | 288 | 24 (8.33%) | 264 (91.67%) | 0.062 |
With | 203 | 29 (14.29%) | 174 (85.71%) | |
Lymphovascular invasion | ||||
No | 335 | 35 (10.45%) | 300 (89.55%) | 0.76 |
Yes | 156 | 18 (11.54%) | 138 (88.46%) | |
Alcohol intake | ||||
Never | 387 | 48 (12.40%) | 339 (87.60%) | 0.031 |
Ever | 104 | 5 (4.81%) | 99 (95.19%) | |
Smoking | ||||
Ever | 137 | 16 (11.68%) | 121 (88.32%) | 0.75 |
Never | 354 | 37 (10.45%) | 317 (89.55%) | |
CRC family history | ||||
Yes | 9 | 2 (22.22%) | 7 (77.78%) | 0.28* |
No | 119 | 13 (10.92%) | 106 (89.08%) | |
Unknown | 363 | |||
MSI status | ||||
MSI | 68 | 4 (5.88%) | 64 (94.12%) | 0.21 |
MSS | 423 | 49 (11.58%) | 374 (88.42%) | |
KRAS status | ||||
Mutation | 212 | 21 (9.91%) | 191 (90.09%) | 0.66 |
Wildtype | 279 | 32 (11.47%) | 247 (88.53%) | |