Fig. 6
From: A novel feedback regulated loop of circRRM2-IGF2BP1-MYC promotes breast cancer metastasis
circRRM2 facilitates cell migration via miR-27b-3p/miR-31-5p. BT-549/MDA-MB-231 cells were transfected with miR-27b-3p (A,B) or miR-31-5p mimics (C, D), or combining with circRRM2 overexpression. The scratch wound healing assay was performed to determine the cell migration ability. The transwell assay was conducted to observe the cell migration/invasion when cells were transfected with miR-27b-3p (E, F) or miR-31-5p mimics (G, H) or combined with circRRM2 overexpression. *P < 0.05, **P < 0.01, ***P < 0.001