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Fig. 5 | Cancer Cell International

Fig. 5

From: Aberrant accumulation of NIK promotes tumor growth by dysregulating translation and post-translational modifications in breast cancer

Fig. 5

NIK protein production increased in malignant breast cancer tissue. A Representative IHC staining images of NIK protein production in normal breast tissue and breast tumors. The scale bar is 500 μm. B Quantification data of the NIK IHC staining images in normal breast tissue and breast tumors ((n = 10 normal, n = 6 stage I, n = 72 stage II, and n = 22 stage III); one-way ANOVA followed by Tukey’s multiple comparison test). C Representative IHC staining images of NIK and cIAP1 protein production in normal breast tissue and breast tumors of consecutive cuts. The scale bar of the low-power field is 1 mm and the scale bar of the high-power field is 100 μm. D Representative scatter plot of NIK and cIAP1 positive percentage in IHC stain tissue. The p-value and equation were calculated by Linear regulation analysis (n = 55). E The graphical summary indicates that the abnormal accumulation of NIK, due to reduced translation of cIAP1, enhances tumor growth by promoting an inflammatory cancer microenvironment. All data are shown as the mean ± SEM. n.s. not significant. * P < 0.05

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