Table 2 Impact of ATG4B expression levels on overall survival by the different demographic and clinicopathologic factors with colorectal cancer
From: ATG4B and pS383/392-ATG4B serve as potential biomarkers and therapeutic targets of colorectal cancer
Variable | No. (%) | CHR (95% CI) | p value* | AHR (95% CI) | p value †| |
|---|---|---|---|---|---|---|
Sex | ||||||
 Female | Low | 25 (53.5) | 1.00 | 1.00 | ||
High | 22 (46.5) | 2.14 (0.90–5.10) | 0.087 | 3.69 (1.43–9.53) | 0.007 a | |
 Male | Low | 38 (53.2) | 1.00 | 1.00 | ||
High | 33 (46.8) | 3.92 (1.79–8.58) | 0.001 | 6.59 (2.81–15.46) | < 0.001 a | |
Age, yrs | ||||||
 ≦ 60 | Low | 22 (48.9) | 1.00 | 1.00 | ||
High | 23 (51.1) | 3.45 (1.24–9.60) | 0.018 | 4.94 (1.72–14.24) | 0.003 a | |
 >60 | Low | 41 (56.2) | 1.00 | 1.00 | ||
High | 32 (43.8) | 2.94 (1.44–5.98) | 0.003 | 6.74 (2.83–16.01) | < 0.001 a | |
Cell differentiation | ||||||
 Well | Low | 3 (68.0) | 1.00 | 1.00 | ||
High | 1 (32.0) | 434.45 (0.00-8.954E + 12) | 0.616 | 434.45 (0.00-8.954E + 12) | 0.616b | |
 Moderate, poor | Low | 60 (44.1) | 1.00 | 1.00 | ||
High | 54 (55.9) | 3.07 (1.69–5.58) | < 0.001 | 5.90 (3.07–11.32) | < 0.001 b | |
AJCC pathological stage | ||||||
 I, II | Low | 23 (41.1) | 1.00 | 1.00 | ||
High | 33 (58.9) | 2.60 (0.85–7.97) | 0.096 | 3.00 (0.85–10.54) | 0.087c | |
 III, IV | Low | 40 (64.5) | 1.00 | 1.00 | ||
High | 22 (35.5) | 6.18 (3.00-12.72) | < 0.001 | 6.14 (2.97–12.70) | < 0.001 c | |
T classification | ||||||
 T1, T2 | Low | 12 (57.1) | 1.00 | 1.00 | ||
High | 9 (42.9) | 3.22 (0.59–17.64) | 0.178 | 5.50 (0.61–49.32) | 0.128d | |
 T3, T4 | Low | 51 (52.6) | 1.00 | 1.00 | ||
High | 46 (47.4) | 3.01 (1.62–5.59) | < 0.001 | 4.73 (2.40–9.31) | < 0.001 d | |
N classification | ||||||
 N0 | Low | 27 (42.2) | 1.00 | 1.00 | ||
High | 37 (57.8) | 2.60 (1.03–6.56) | 0.043 | 2.65 (0.97–7.25) | 0.059e | |
 N1, N2 | Low | 36 (66.7) | 1.00 | 1.00 | ||
High | 18 (33.3) | 6.10 (2.77–13.43) | < 0.001 | 6.02 (2.71–13.35) | < 0.001 e | |
Postoperative RT | ||||||
 No | Low | 56 (50.9) | 1.00 | 1.00 | ||
High | 54 (49.1) | 2.83 (1.56–5.14) | 0.001 | 4.88 (2.59–9.21) | < 0.001 a | |
 Yes | Low | 7 (87.5) | 1.00 | 1.00 | ||
High | 1 (12.5) | 22097.29 (0.00-1.528E + 052) | 0.859 | 22097.29 (0.00-1.528e + 052) | 0.859a |