Table 3 Impact of pS383/392-ATG4B expression levels on overall survival by the different demographic and clinicopathologic factors with colorectal cancer
From: ATG4B and pS383/392-ATG4B serve as potential biomarkers and therapeutic targets of colorectal cancer
Variable | No. (%) | CHR (95% CI) | p value* | AHR (95% CI) | p value †| |
|---|---|---|---|---|---|---|
Sex | ||||||
 Female | Low | 35 (74.5) | 1.00 | 1.00 | ||
High | 12 (25.5) | 1.98 (0.82–4.78) | 0.127 | 1.03 (0.37–2.90) | 0.953a | |
 Male | Low | 47 (66.2) | 1.00 | 1.00 | ||
High | 24 (33.8) | 4.04 (1.94–8.40) | < 0.001 | 3.72 (1.70–8.14) | 0.001 a | |
Age, years | ||||||
 ≦ 60 | Low | 29 (64.4) | 1.00 | 1.00 | ||
High | 16 (35.6) | 3.73 (1.49–9.35) | 0.005 | 2.30 (0.79–6.65) | 0.125a | |
 >60 | Low | 53 (72.6) | 1.00 | 1.00 | ||
High | 20 (27.4) | 2.74 (1.36–5.49) | 0.005 | 2.43 (1.14–5.21) | 0.022 a | |
Cell differentiation | ||||||
 Well | Low | 3 (75.0) | 1.00 | 1.00 | ||
High | 1 (25.0) | 434.45 (0.00-8.954E + 12) | 0.616 | 92.86 (0.00-13265331940) | 0.636b | |
 Moderate, poor | Low | 79 (69.3) | 1.00 | 1.00 | ||
High | 35 (30.7) | 2.93 (1.67–5.13) | < 0.001 | 2.26 (1.27-4.00) | 0.005 b | |
AJCC pathological stage | ||||||
 I, II | Low | 50 (89.3) | 1.00 | 1.00 | ||
High | 6 (10.7) | 4.74 (1.53–14.71) | 0.007 | 4.81 (1.53–15.09) | 0.007 c | |
 III, IV | Low | 32 (51.6) | 1.00 | 1.00 | ||
High | 30 (48.4) | 2.12 (1.06–4.24) | 0.034 | 2.07 (1.03–4.16) | 0.042 c | |
T classification | ||||||
 T1, T2 | Low | 21 (100.0) | 1.00 | 1.00 | ||
High | 0 (0.0) | Incalculable | Incalculable | |||
 T3, T4 | Low | 61 (62.9) | 1.00 | 1.00 | ||
High | 36 (37.1) | 2.82 (1.57–5.07) | 0.001 | 2.86 (1.51–5.42) | 0.001 d | |
N classification | ||||||
 N0 | Low | 55 (85.9) | 1.00 | 1.00 | ||
High | 9 (14.1) | 5.38 (2.17–13.36) | < 0.001 | 5.32 (1.98–14.27) | 0.001 e | |
 N1, N2 | Low | 27 (50.0) | 1.00 | 1.00 | ||
High | 27 (50.0) | 2.19 (1.01–4.76) | 0.047 | 2.12 (0.97–4.64) | 0.060e | |
Postoperative RT | ||||||
 No | Low | 79 (71.8) | 1.00 | 1.00 | ||
High | 31 (28.2) | 3.90 (2.22–6.87) | < 0.001 | 3.02 (1.63–5.62) | < 0.001 a | |
 Yes | Low | 3 (37.5) | 1.00 | 1.00 | ||
High | 5 (62.5) | 0.35 (0.02–6.15) | 0.470 | 14.53 (0.00-326310532.6) | 0.757a |