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Fig. 3 | Cancer Cell International

Fig. 3

From: High anti-tumor activity of a novel alpha-fetoprotein-maytansinoid conjugate targeting alpha-fetoprotein receptors in colorectal cancer xenograft model

Fig. 3

Biodistribution and metabolism of the ACT-101-ABZ982 DPR 4.0 conjugate. A Toxin levels (free ABZ981 and metabolites) concentration (ng/mg) in homogenized tumor and off target tissues (heart, kidney, liver, lung and bone marrow) at 4, 8 and 24 h after drug administration, detected using LC–MS/MS (n = 3 per timepoint); B Free toxin (ABZ981) and metabolites: S-methyl derivative (ABZ981-Me-S), S-methyl-sulfoxide derivate (ABZ981-Me-SO) and S-methyl sulfone derivative (ABZ981-Me-SO2) concentration (ng/mg) in homogenized mouse liver tissue at 4, 8 and 24 h after drug administration (n = 3 per timepoint)

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Cancer Cell International

ISSN: 1475-2867

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