Time (hr) | DM1 conjugate | DM4 conjugate | ABZ981 conjugate | |||
---|---|---|---|---|---|---|
Free DM1 ng/mg tissue | % of total dose administered* | Free DM4 ng/mg tissue | % of total dose administered* | Free ABZ981 ng/mg tissue | % of total dose administered* | |
A. Tumor level | ||||||
4 | 0.0137 ± 0.0084 | 0.013 ± 0.002% | 0.0040 ± 0.0014 | 0.003 ± 0.001% | 0.0766 ± 0.0047 | 0.068 ± 0.030% |
8 | 0.0647 ± 0.0222 | 0.075 ± 0.058% | 0.0041 ± 0.0003 | 0.003 ± 0.001% | 0.1860 ± 0.0834 | 0.266 ± 0.213% |
24 | nd | n/a | 0.0086 ± 0.0038 | 0.007 ± 0.001% | 0.0658 ± 0.0753 | 0.030 ± 0.029% |
B. Plasma levels | ||||||
0.25 | 0.019 ± 0.0081 | 0.0012 ± 0.0005 | 0.003 ± 0.0001 | 0.0002 ± 0 | 0.006 ± 0.006 | 0.0004 ± 0.0004 |
1 | 0.009 ± 0.003 | 0.0006 ± 0.0002 | 0.002 ± 0.0002 | 0.0001 ± 0 | 0.003 ± 0.002 | 0.0002 ± 0.0001 |
4 | 0.020 ± 0.007 | 0.0013 ± 0.0004 | n/a | n/a | 0.006 ± 0.0004 | 0.0004 ± 0 |
8 | 0.017 ± 0.0013 | 0.0011 ± 0.00001 | n/a | n/a | 0.006 ± 0.002 | 0.0003 ± 0.0001 |
24 | 0.003 ± 0.001 | 0.0002 ± 0.00001 | n/a | n/a | 0.002 ± 0 | 0.0001 ± 0 |