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Table 3 Tumor and plasma levels of toxin by conjugate

From: High anti-tumor activity of a novel alpha-fetoprotein-maytansinoid conjugate targeting alpha-fetoprotein receptors in colorectal cancer xenograft model

Time (hr)

DM1 conjugate

DM4 conjugate

ABZ981 conjugate

Free DM1 ng/mg tissue

% of total dose administered*

Free DM4 ng/mg tissue

% of total dose administered*

Free ABZ981 ng/mg tissue

% of total dose administered*

A. Tumor level

4

0.0137 ± 0.0084

0.013 ± 0.002%

0.0040 ± 0.0014

0.003 ± 0.001%

0.0766 ± 0.0047

0.068 ± 0.030%

8

0.0647 ± 0.0222

0.075 ± 0.058%

0.0041 ± 0.0003

0.003 ± 0.001%

0.1860 ± 0.0834

0.266 ± 0.213%

24

nd

n/a

0.0086 ± 0.0038

0.007 ± 0.001%

0.0658 ± 0.0753

0.030 ± 0.029%

B. Plasma levels

0.25

0.019 ± 0.0081

0.0012 ± 0.0005

0.003 ± 0.0001

0.0002 ± 0

0.006 ± 0.006

0.0004 ± 0.0004

1

0.009 ± 0.003

0.0006 ± 0.0002

0.002 ± 0.0002

0.0001 ± 0

0.003 ± 0.002

0.0002 ± 0.0001

4

0.020 ± 0.007

0.0013 ± 0.0004

n/a

n/a

0.006 ± 0.0004

0.0004 ± 0

8

0.017 ± 0.0013

0.0011 ± 0.00001

n/a

n/a

0.006 ± 0.002

0.0003 ± 0.0001

24

0.003 ± 0.001

0.0002 ± 0.00001

n/a

n/a

0.002 ± 0

0.0001 ± 0

  1. n/a Not available as average of non-detected or below LOQ data points
  2. *Calculated as: \(\% {\text{ of total dose administered }} = \frac{{{\text{measured concentration }}\left( {{\text{ng}}/{\text{mg}}} \right) \, \times {\text{ estimated tissue weight }}\left( {{\text{mg}}} \right) \times { 1}00\% }}{{{\text{Amount of drug injected based on body weight }}\left( {{\text{ng}}} \right)}}\)