Table 5 Cytotoxicity (IC50) of high DPR ACT-101-ABZ982 and ACT-101 ABZ1827 conjugates in COLO-205 cells
5000 cells/well (Plate 1) | 5000 cells/well (Plate 2) | 2500 cells/well (Plate 1) | 2500 cells/well (Plate 2) | |
|---|---|---|---|---|
ACT-101-ABZ982 high DPR | 4.32 nM | 5.14 nM | 3.17 nM | 3.60 nM |
ACT-101-ABZ1827 high DPR | 6.52 nM | 7.13 nM | 5.08 nM | 4.88 nM |
ABZ981(linker-payload) | 6.86 nM | 7.29 nM | 4.92 nM | 5.17 nM |