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Fig. 4 | Cancer Cell International

Fig. 4

From: CAFs-derived rho-associated kinase1 mediated EMT to promote laryngeal squamous cell carcinoma metastasis

Fig. 4

Signal molecules of JAK2, STAT3 and ERK1/2 were of great importance in the metastasis of LSCC. (A) The expressions of ROCK1, ROCK2, JAK2, STAT3 and ERK1/2 were verified by Western Blot. The p-JAK2, p-STAT3 and p-ERK1/2 levels were markedly increased in Hep2/NFs/ROCK1 cells. (B) Protein ratio in Hep2/NFs/vector or Hep2/NFs/ROCK1 cells (*P < 0.05, **P < 0.01). (C) The expressions of ROCK1, ROCK2, JAK2, STAT3 and ERK1/2 were verified by Western Blot in Hep2/CAFs/si-ROCK1 cells. P-JAK2, p-STAT3 and p-ERK1/22 levels were markedly decreased in Hep2/CAFs/si-ROCK1 cells. (D) Protein ratio in Hep2/CAFs/si-NC or Hep2/CAFs/si-ROCK1 cells (**P < 0.01)

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Cancer Cell International

ISSN: 1475-2867

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