Fig. 3

AUP1 expression is associated with gene mutations, chromosome abnormality, and genomic stability. A We identified potential driving genes that might impact AUP1 in each group, and there is a strong correlation between TP53 in astrocytoma groups. B, C The boxplots revealed the association of AUP1 with TP53 status in IDH wildtype and mutant astrocytoma groups. D Higher AUP1 also correlated with EGFR amplification and E chromosome 7 gain and 10 loss. F, G For genomic stability, the increased AUP1 positively correlated to TMB in astrocytoma (H) but not oligodendroglioma. I, J Conversely, the AUP1 was reversely associated with MSI in astrocytoma K but not oligodendroglioma