Fig. 1

Genetic landscape and alterations of MRCCGs in STAD.

(A) The heatmap of the expression distributions of the 24 differential MRCCGs between normal and tumor samples. Red or blue represents upregulation and downregulation, respectively. (B) Box plot displaying the expression distributions of MRCCGs crosstalk between normal and tumor samples. Red or blue dots represent tumor and normal samples, respectively. (C) Mutation frequency of the 24 different expressed mitochondrial complex genes of STAD patients in the TCGA-STAD and GSE84437 cohorts. (D) Frequencies of CNV gain, loss, and non-CNV among MRCCGs. The abscissa was the MRCCGs, and the ordinate was the mutation frequency. Red represents an increase in copy number, and green represents the loss of copy number. (E) Locations of CNV alterations of MRCCGs on 24 chromosomes. The *** represents p < 0.001, ** represents p < 0.01, * represents p < 0.05