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Fig. 6 | Cancer Cell International

Fig. 6

From: Colorectal cancer-derived small extracellular vesicles induce TGFβ1-mediated epithelial to mesenchymal transition of hepatocytes

Fig. 6

CRC_sEVs induce the modulation of TGFβ/SMAD targets associated with EMT in hepatocytes. Western blot assays were performed to verify the ability of SW480_ and SW620_sEVs to modulate SMAD 2/3 phosphorylation in hepatocytes (a), the expression of SNAIL and SLUG (b), and mesenchymal (c) and epithelial markers (d). Each Western blot is associated with the corresponding densitometric analysis where the reported values are the mean of at least 2 independent experiments (± SD) of the protein normalized vs loading control (Tubulin or GAPDH). e Western blot analyses of SNAIL, SLUG, and Vimentin in hepatocytes treated with CRC_P/sEVs and HS/sEVs; Ctrl: untreated control cells. *p ≤ 0.05; **p ≤ 0.01

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