Syndecan-1 as an immunogene in Triple-negative breast cancer: regulation tumor-infiltrating lymphocyte in the tumor microenviroment and EMT by TGFb1/Smad pathway

Zhong, Ying; Li, Fangyuan; Zhang, Sumei; Yang, Zhenli; Ren, Xinyu; Cao, Xi; Xu, Yali; Guo, Dan; Zhou, Yidong; Mao, Feng; Shen, Songjie; Sun, Qiang

doi:10.1186/s12935-023-02917-7

Table 1 The most significant pathway by functional Enrichment analysis

From: Syndecan-1 as an immunogene in Triple-negative breast cancer: regulation tumor-infiltrating lymphocyte in the tumor microenviroment and EMT by TGFb1/Smad pathway

Pathway	padj	ES	NES	Size
GO_RESPONSE_TO_ACID_CHEMICAL	0.01765	− 0.50902	− 2.22169	25
GO_SUPRAMOLECULAR_FIBER_ORGANIZATION	0.01765	− 0.48201	− 2.10382	25
GO_REGULATION_OF_BLOOD_PRESSURE	0.01765	− 0.50048	− 2.15203	24
GO_HEART_DEVELOPMENT	0.01765	− 0.50506	− 2.25404	27
GO_MUSCLE_CELL_PROLIFERATION	0.01765	− 0.50868	− 2.32071	29
GO_CELLULAR_RESPONSE_TO_NITROGEN_COMPOUND	0.01765	− 0.47024	− 2.16689	30
GO_RESPONSE_TO_NITROGEN_COMPOUND	0.01765	− 0.39294	− 2.14571	56
GO_TRANSMEMBRANE_RECEPTOR_PROTEIN_TYROSINE_KINASE_SIGNALING_PATHWAY	0.01765	− 0.38748	− 2.12596	57
GO_ENZYME_LINKED_RECEPTOR_PROTEIN_SIGNALING_PATHWAY	0.01765	− 0.35315	− 2.08362	79
GO_CELLULAR_RESPONSE_TO_ENDOGENOUS_STIMULUS	0.01765	− 0.36486	− 2.16811	81
GO_RESPONSE_TO_ENDOGENOUS_STIMULUS	0.01765	− 0.35867	− 2.2226	101
GO_REGULATION_OF_SMALL_MOLECULE_METABOLIC_PROCESS	0.021166	− 0.53436	− 2.20154	21
GO_RESPONSE_TO_ALCOHOL	0.021166	− 0.53187	− 2.22304	22
GO_GLIOGENESIS	0.021166	− 0.50307	− 2.12947	23
GO_NEGATIVE_REGULATION_OF_LOCOMOTION	0.021166	− 0.41126	− 2.0009	36
GO_SMALL_MOLECULE_METABOLIC_PROCESS	0.021166	− 0.38572	− 2.03119	48
GO_RESPONSE_TO_HORMONE	0.027985	− 0.33928	− 1.96476	72
GO_POSITIVE_REGULATION_OF_CATALYTIC_ACTIVITY	0.027985	− 0.3335	− 1.93399	73
GO_CHEMICAL_HOMEOSTASIS	0.027985	− 0.32243	− 1.90815	80
GO_MUSCLE_ORGAN_DEVELOPMENT	0.027985	− 0.59343	− 2.22904	16
GO_VASCULAR_PROCESS_IN_CIRCULATORY_SYSTEM	0.027985	− 0.5305	− 2.14832	20
GO_SMOOTH_MUSCLE_CELL_PROLIFERATION	0.027985	− 0.45941	− 2.03232	26
GO_CIRCULATORY_SYSTEM_PROCESS	0.027985	− 0.39925	− 1.98962	40
GO_IMMUNE_EFFECTOR_PROCESS	0.027985	0.348071	1.880554	87
GO_CELLULAR_RESPONSE_TO_OXYGEN_CONTAINING_COMPOUND	0.027985	− 0.3392	− 1.93643	67
GO_CIRCULATORY_SYSTEM_DEVELOPMENT	0.027985	− 0.32118	− 1.88674	77
GO_REGULATION_OF_CELLULAR_COMPONENT_MOVEMENT	0.027985	− 0.31481	− 1.90474	89
GO_FAT_CELL_DIFFERENTIATION	0.031576	− 0.57632	− 2.16475	16
GO_LEUKOCYTE_MEDIATED_IMMUNITY	0.031576	0.402027	1.969224	54
GO_RESPONSE_TO_OXYGEN_CONTAINING_COMPOUND	0.031576	− 0.29632	− 1.83935	100

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ISSN: 1475-2867

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