Skip to main content

Table 2 Genotypes distribution of NRF2 rs6721961 and rs6726395 in four groups and the risks of CHB, LC, and HCC patients

From: Antioxidants-related nuclear factor erythroid 2-related factor 2 gene variants associated with HBV-related liver disease

Genotypes

Controls (N = 217)

CHB (N = 110)

LC (N = 86)

HCC (N = 260)

CHB vs. controls

LC vs. controls

HCC vs. controls

HCC vs. CHB

OR (95% CI)a

P

OR (95% CI) a

P

OR (95% CI)a

P

OR (95% CI)a

P

rs6721961

            

G allele

333

178

137

387

1.00ref

 

1.00ref

 

1.00ref

 

1.00ref

 

T allele

101

42

35

133

0.752 (0.477–1.186)

0.220

0.830 (0.525–1.314)

0.427

1.192 (0.858–1.657)

0.295

1.561 (1.003–2.430)

0.048

GG

128

75

52

143

1.00ref

 

1.00ref

 

1.00ref

 

1.00ref

 

GT

77

28

33

101

0.701 (0.390–1.260)

0.235

1.073 (0.613–1.876)

0.806

1.402 (0.913–2.153)

0.123

2.298 (1.282–4.119)

0.005

TT

12

7

1

16

0.685 (0.222–2.114)

0.511

0.185 (0.023–1.518)

0.116

1.042 (0.447–2.428)

0.925

1.129 (0.390–3.267)

0.823

TT + GT vs.GGb

    

0.670 (0.366–1.227)

0.195

0.894 (0.484–1.648)

0.719

1.443 (0.908–2.292)

0.121

2.039 (1.184–0.510)

0.010

TT vs. GG + GTc

    

0.899 (0.286–2.824)

0.856

0.224 (0.028–1.829)

0.163

0.953 (0.408–2.224)

0.911

0.707 (0.237–2.109)

0.534

rs6726395

            

G allele

258

139

111

324

1.00ref

 

1.00ref

 

1.00ref

 

1.00ref

 

A allele

176

81

61

196

0.817 (0.557–1.197)

0.299

0.839 (0.570–1.234)

0.371

0.966 (0.725–1.289)

0.816

1.033(0.707–1.508)

0.868

GG

81

41

32

103

1.00ref

 

1.00ref

 

1.00ref

 

1.00ref

 

AG

96

57

47

118

1.098 (0.615–1.959)

0.751

1.315 (0.745–2.321)

0.344

1.065 (0.690–1.646)

0.776

0.768(0.441–1.336)

0.350

AA

40

12

7

39

0.542 (0.230–1.277)

0.161

0.473 (0.185–1.211)

0.119

0.891 (0.494–1.606)

0.701

1.395(0.577–3.369)

0.460

AA + AG vs. GGb

    

1.107 (0.604–2.029)

0.743

1.128 (0.612–2.076)

0.700

0.858 (0.540–1.362)

0.515

0.859 (0.504 − 0.464)

0.577

AA vs. AG + GGc

    

0.519 (0.235–1.148)

0.105

0.448 (0.185–1.086)

0.075

0.867 (0.499–1.506)

0.611

1.726 (0.742–4.019)

0.205

  1. CHB, chronic hepatitis B; LC, liver cirrhosis; HCC, hepatocellular carcinoma
  2. a Adjusted for gender, age, BMI, ethnicity, smoking and alcohol status
  3. bDominant model
  4. cRecessive model
  5. Boldfaced values indicate a significant difference
Back to article page

Cancer Cell International

ISSN: 1475-2867

Contact us