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Table 3 Haplotype frequencies analysis of NRF2 and the risk of CHB, and LC, and HCC.

From: Antioxidants-related nuclear factor erythroid 2-related factor 2 gene variants associated with HBV-related liver disease

Haplotype

Controls (freq)

CHB (freq)

LC (freq)

HCC (freq)

CHB vs. controls

 

LC vs. controls

 

HCC vs. controls

OR (95% CI)

P OR

 

OR (95% CI)

P OR

 

OR (95% CI)

P OR

G-A

0.226

0.218

0.182

0.170

0.953 (0.645–1.410)

0.810

 

0.762 (0.487–1.193)

0.234

 

0.700 (0.508–0.965)

0.028

G-G

0.541

0.591

0.614

0.575

1.226 (0.883–1.703)

0.223

 

1.351 (0.942–1.937)

0.102

 

1.145 (0.885–1.479)

0.302

T-A

0.180

0.150

0.173

0.207

0.809 (0.519–1.261)

0.349

 

0.953 (0.599–1.518)

0.840

 

1.195 (0.864–1.652)

0.281

T-G

0.053

0.040

0.031

0.048

0.750 (0.340–1.656)

0.476

 

0.567 (0.217–1.483)

0.242

 

0.907 (0.508–1.620)

0.742

  1. freq frequency, CHB chronic hepatitis B, LC liver cirrhosis, HCC hepatocellular carcinoma
  2. Boldfaced values indicate a significant difference.