Fig. 1

KPC1-mediated generation of p50 from p105, inhibits tumor growth. Growth rates and weights of tumor xenografts grown in mice, and derived from U87-MG (A) and MDA-MB 231 (B). Cells expressed as indicated, an empty vector (V0), Myc-KPC1, FLAG-p50 or Myc-KPC1I1256A (a RING mutant of KPC1 which is inactive). C Tumors derived from U87-MG cells expressing either an empty vector, KPC1, p50 or mutated and inactive KPC1, and harvested 3 weeks after inoculation. Reproduced by permission of Elsevier publisher (license number 5494121109876)