MicroRNAs as the critical regulators of autophagy-mediated cisplatin response in tumor cells

Tolue Ghasaban, Faezeh; Maharati, Amirhosein; Akhlaghipour, Iman; Moghbeli, Meysam

doi:10.1186/s12935-023-02925-7

Cancer Cell International

Table 1 Role of miRNAs in autophagy-mediated cisplatin response

From: MicroRNAs as the critical regulators of autophagy-mediated cisplatin response in tumor cells

miRNA	Type	Target	Samples	Autophagy	CDDP response	Clinical application	Study
Signaling pathways
miR-181	Non-small cell lung cancer	PI3K/Akt/mTOR pathway	6T 6 N* A549/DDP cell line	Induction	Increased CDDP sensitivity	Diagnosis	Liu [42]
miR-22	Osteosarcoma	PI3K/Akt/mTOR pathway	MG-63, MG-63/CDDP, U2OS, Saos2 and OS9901 cell lines Xenograft model	Inhibition	Increased CDDP sensitivity	Diagnosis	Meng [43]
miR-5047	Cervical canecr	VEGFA	25T 25 N HeLa and SiHa cell lines	Inhibition	Increased CDDP sensitivity	Diagnosis	Guo [50]
miR-99a-5p	Gastric cancer	MTMR3	25R 75 S* BGC823, SGC7901, and SGC7901CDDP cell lines Xenograft model	Induction	Increased CDDP resistance	Diagnosis	Sun [51]
miR-339-5p	Laryngeal carcinoma	TAK1	Hep-2 cell line	Inhibition	Increased CDDP sensitivity	Diagnosis	Li [52]
miR-222	Bladder cancer	PPP2R2A	T24 and 5637 cell lines	Inhibition	Increased CDDP resistance	Diagnosis	Zeng [60]
miR-26a	Glioblastoma	GSK3β	U87MG and U251MG cell lines	Induction	Increased CDDP resistance	Diagnosis	Ma [65]
miR-205	Nasopharyngeal carcinoma	HER3	CNE1, CNE2, SUNE1, and HK1 cell lines	Induction	Increased CDDP sensitivity	Diagnosis	Hao [67]
miR-144	Anaplastic thyroid carcinoma	TGF-α	5T 5 N ARO and TPC1 cell lines Xenograft model	Inhibition	Increased CDDP sensitivity	Diagnosis	Liu [69]
miR-144-3p	Anaplastic thyroid carcinoma	TGF-α	5T 5 N TPC1 and BHT101 cell lines Xenograft model	Inhibition	Increased CDDP sensitivity	Diagnosis	Liu [70]
miR-145-5p	Laryngeal squamous cell carcinoma	PRKCI	FD-LSC-1 and Tu 177 cell lines Xenograft model	Induction	Increased CDDP sensitivity	Diagnosis	Gao [73]
miR-425-3p	Non-small cell lung cancer	AKT1	19R 19 S 15 after first trial 15 after last trial A549 and A549/DDP cell lines	Induction	Increased CDDP resistance	Diagnosis and prognosis	Ma [76]
miR-30a	Ovarian/ breast/ liver cancer	Beclin-1	HeLa, MCF-7, HepG2, and HepS cell lines Xenograft model	Inhibition	Increased CDDP sensitivity	Diagnosis	Zou [81]
miR-30a-5p	Small Cell Lung Cancer	Beclin-1	22R 32 S H446 and Letp cell lines	Inhibition	Increased CDDP sensitivity	Diagnosis	Yang [82]
miR-216b	Non-small cell lung cancer	Beclin-1	40T 40 N A549 cell line Xenograft model	Inhibition	Increased CDDP sensitivity	Diagnosis	Chen [83]
miR-148a-3p	Gastric cancer	AKAP1/RAB12	105T 105 N BGC823CDDP, SGC7901CDDP, BGC823, and SGC7901 cell lines Xenograft model	Inhibition	Increased CDDP sensitivity	Diagnosis and prognosis	Li [90]
miR-136-5p	Laryngeal squamous cell carcinoma	ROCK1	FD-LSC-1 and FaDu cell lines	Induction	Increased CDDP sensitivity	Diagnosis	Yang [95]
miR-142-3p	Gastric cancer	ROCK2	100T 100 N 48 GC blood sample 48 healthy blood sample AGS, SGC-7901, MKN-45, and BGC-823 cell lines xenograft model	Inhibition	Increased CDDP resistance	Diagnosis and prognosis	Peng [97]
Apoptosis and drug efflux
miR-15a-3p	Non-small cell lung cancer	BCL2	Calu1 cell line	Induction	Increased CDDP sensitivity	Diagnosis	Bozok [105]
miR-143	Cervical cancer	BCL2	HeLa and CaSki cell lines	Induction	Increased CDDP sensitivity	Diagnosis	Esfandyari [106]
miR-7-5p	Cervical cancer	PARP-1/Bcl-2	15T 15 N HeLa and SiHa cell lines	Induction	Increased CDDP resistance	Diagnosis	Yang [107]
miR-30a	Oral squamous carcinoma	Beclin1	13T 14 N SCC084 cell line	Inhibition	Increased CDDP sensitivity	Diagnosis	Kulkarni [108]
miR-30	Gastric cancer	LC3II/ LC3-I	SGC-7901 cell line	Inhibition	Increased CDDP sensitivity	Diagnosis	Du [111]
miR-22	Osteosarcoma	caspase-3/ Bcl-2/ ATG5/ beclin1/ LC3B	MG-63, MG-63/CDDP, U2OS, Saos2 and OS9901 cell lines Xenograft model	Inhibition	Increased CDDP sensitivity	Diagnosis	Meng [116]
miR-22	Osteosarcoma	MTDH	MG-63 cell line	Inhibition	Increased CDDP sensitivity	Diagnosis	Wang [117]
Ubiquitin-like modifiers and autophagy receptors
miR-199a-5p	Small cell lung cancer	p62	30T 30 N NCI-H446 and H69PR cell lines Xenograft model	Induction	Increased CDDP resistance	Diagnosis	Li [124]
miR-146a	Lung cancer	CHOP	69T 69 N A549 and H446 cell lines Xenograft model	Inhibition	Increased CDDP resistance	Diagnosis	Tan [131]
miR-133a	Ovarian cancer	YES1	24R 12 S SKOV3 and A2780 cell lines Xenograft model	Inhibition	Increased CDDP sensitivity	Diagnosis	Zhou [134]
Transcription factors and DNA binding proteins
miR-29c-3p	Ovarian cancer	FOXP1/ATG14	SKOV3 and A2780 cell lines Xenograft model	Inhibition	Increased CDDP sensitivity	Diagnosis	Hu [136]
miR-125b	Thyroid cancer	ATG7/ Foxp3	30T 30 N WRO, FRO, and KAT18 cell lines Xenograft model	Induction	Increased CDDP sensitivity	Diagnosis	Wang [137]
miR-152	Ovarian cancer	ATG14	35T A2780/CP70, SKOV3/DDP, A2780 and SKOV3 cell lines Xenograft model	Inhibition	Increased CDDP sensitivity	Diagnosis	He [139]
miR-579-3p	Osteosarcoma	MSH6	SCSP-5030 and TCHu124 cell lines Xenograft model	Inhibition	Increased CDDP sensitivity	Diagnosis	Zhan [145]
miR-216b	Non-small cell lung cancer	Beclin-1	40T 40 N A549 and cisplatin resistance A549/DDP cell lines Xenograft model	Inhibition	Increased CDDP sensitivity	Diagnosis	Chen [151]
miR-181a-5p	Breast cancer	VDR	HS578T, HCC70, MDA-MB-231, MDA-MB-468 and BT549 cell lines	Induction	Increased CDDP sensitivity	Diagnosis	Lin [154]
Autophagy-related genes
miR-1278	Nasopharyngeal carcinoma	ATG2B	90T 90 N CNE-1, CNE-2, C666-1, 5–8 F and HONE-1 cell lines Xenograft model	Inhibition	Increased CDDP sensitivity	Diagnosis and prognosis	Zhao [161]
miR-376a	laryngocarcinoma	ATG2A	30T 30 N SNU46 and M4E cell lines Xenograft model	Inhibition	Increased CDDP sensitivity	Diagnosis	Feng [163]
miR-1	Non-small cell lung cancer	ATG3	30R 30 S A549 and H1299 cell lines	Inhibition	Increased CDDP sensitivity	Diagnosis	Hua [164]
miR-651	Cervical canecr	ATG3	30T 30 N 30T blood sample 30 N blood sample C33A, HT-3, HeLa/S, and HeLa/DDP cell lines	Inhibition	Increased CDDP sensitivity	Diagnosis and prognosis	Zhu [165]
miR-16	Osteosarcoma	ATG4B	30T 30 N SAOS2 and U2OS cell lines	Inhibition	Increased CDDP sensitivity	Diagnosis	Liu [168]
miR-101-3p	Non-small cell lung cancer	ATG4D	A549, PC-9, NCI-H1299, and HCC827 cell lines Xenograft model	Inhibition	Increased CDDP sensitivity	Diagnosis	Cui [169]
miR-101	Hepatocellular carcinoma	RAB5A/ STMN1/ ATG4D	HepG2 cell lines	Inhibition	Increased CDDP sensitivity	Diagnosis	Xu [170]
miR-30e	Gastric cancer	ATG5	SGC7901 cell line Xenograft model	Inhibition	Increased CDDP sensitivity	Diagnosis	Zhang [173]
miR-181a	Gastric cancer	ATG5	SGC7901/CDDP cell line Xenograft model	Inhibition	Increased CDDP sensitivity	Diagnosis	Zhao [174]
miR-1301	Ovarian cancer	ATG5/ Beclin1/ EMT	SKOV3 cell line	Inhibition	Increased CDDP sensitivity	Diagnosis	Yu [175]
miR-30b	Gastric cancer	ATG5	AGS, HGC-27 and the 293T cell lines	Inhibition	Increased CDDP sensitivity	Diagnosis	Xi [176]
miR-17	Non-small cell lung cancer	ATG7	50T 50 N A549 and H1299 cell lines	Inhibition	Increased CDDP sensitivity	Diagnosis	Sun [180]
miR-138-5p	Non-small-cell lung cancer	TRIM65	30R 30 S A549 and A549/DDP cell lines Xenograft model	Inhibition	Increased CDDP sensitivity	Diagnosis	Pan [185]
miR-199a-5p	Hepatocellular carcinoma	ATG7	21T blood sample before and after treatment Huh7 cells, HepG2 cell lines	Inhibition	Increased CDDP sensitivity	Diagnosis	Xu [186]
miR-654-5p	Non-small cell lung cancer	ATG7	108T 108 N H1975, H820, H1299, H358, and A549 cell lines	Inhibition	Increased CDDP sensitivity	Diagnosis	Kong [187]
miR-17	Nonsmall cell lung cancer	ATG7	A549 and H1299 cell lines Xenograft model	Inhibition	Increased CDDP sensitivity	Diagnosis	Huang [188]
miR-7	Bladder cancer	ATG7	47T 47 N T24T and EJ cell lines Xenograft model	Inhibition	Increased CDDP sensitivity	Diagnosis	Wang [189]
miR-646	Oral squamous cell carcinoma	ATG13	SCC-15 and CAL-27 cell lines Xenograft model	Inhibition	Increased CDDP resistance	Diagnosis	Gao [190]
miR-186	Colorectal cancer	ATG14	50T 50 N SW620 and SW480 cell lines Xenograft model	Inhibition	Increased CDDP sensitivity	Diagnosis	Han [191]
miR-410	Osteosarcoma	ATG16L1	40T 40 N U2OS and MG-63 cell lines	Inhibition	Increased CDDP sensitivity	Diagnosis and prognosis	Chen [195]
Structural factors and enzymes
miR-205	Prostate cancer	RAB27A/LAMP3	DU145 and PC-3 PCa cell lines Xenograft model	Inhibition	Increased CDDP sensitivity	Diagnosis	Pennati [199]
miR-140-5p	Non-small cell lung cancer	WEE1	30R 30 S A549 and H1299 cell lines Xenograft model	Inhibition	Increased CDDP sensitivity	Diagnosis	Fu [200]
miR-329-3p	Neuroblastoma	MYO10	26T 26 N HUVEC and NB cell lines	Inhibition	Increased CDDP sensitivity	Diagnosis	Wang [203]
miR-124/ miR-142	Non-small cell lung cancer	SIRT1	36T 36 N H1299 and H1299/CDDP cell lines Xenograft model	Inhibition	Increased CDDP sensitivity	Diagnosis	Song [208]

*Tumor (T) tissues and Normal (N) margins*Resistant (R) patients and Sensitive (S) patients to CDDP

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ISSN: 1475-2867

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