Table 2 Anti-cancer drugs mediate resistance through CS-GRP78.
From: Cell surface GRP78: a potential mechanism of therapeutic resistant tumors
Drugs | Target | Reference |
|---|---|---|
Obatoclax (OBX)- BCL2 family inhibitor | Increases CS-GRP78 and their downstream signaling | [88] |
LCL161- Smac mimetic | Blocks OBX induced AKT activation through CS-GRP78 | [88] |
ONC212-A fluorinated imipridone | Increases CS-GRP78 expression and IGF-R expression | [24] |
AG1024-IGF-R inhibitor | Synergy with ONC212 | [24] |
Vemurafenib-BRAF inhibitor | Regulates subcellular localization of BRAF and GRP78 | [92] |
C-61 -SYK P-Site inhibitor | Turns off anti-apoptotic aspects of GRP78 | [99] |