Table 1 Summary of the roles of different RGS proteins in cancers

Tumor Initiator

RGS1

Gastric cancer [139], cervical cancer [140]

RGS2

Prostate cancer [86]

RGS3

Breast cancer [88], lung cancer [89], gastric cancer [65, 90], glioma [91]

RGS4

Papillary thyroid cancer [92], lung cancer [94], glioma [95], osteosarcoma [97]

RGS5

Squamous cell carcinoma [98], renal cell carcinoma [101]

RGS6

Ovarian cancer [99, 134], pancreatic cancer [107]

RGS7

Melanoma [108]

RGS8

Prostate cancer [109]

RGS11

Lung cancer [111]

RGS16

Colorectal cancer [116], glioma [119]

RGS17

Hepatocellular carcinoma [120], prostate cancer [72, 121, 138], lung cancer [132, 133, 138]

RGS19

Ovarian cancer [131]

RGS20

Breast cancer [127], bladder cancer [98, 136], penile cancer [141]

Tumor Suppressor

RGS1

Melanoma [82], multiple myeloma [83]

RGS2

Breast cancer [84], colorectal cancer [85], bladder cancer [87], ovarian cancer [129]

RGS4

Breast cancer [93], melanoma [96]

RGS5

Ovarian cancer [99], liver cancer [100], lung cancer [102], perivascular soft tissue tumor [103]

RGS6

Bladder cancer [104], breast cancer [105], lung cancer [106]

RGS10

Ovarian caner [74, 130], colorectal carcinoma [110]

RGS12

Oral squamous cell carcinoma [112], prostate cancer [113], osteosarcoma [114]

RGS16

Breast cancer [115], pancreatic cancer [117], chondrosarcoma [118]

RGS17

Breast cancer [128], ovarian cancer [62]