From: RGS proteins and their roles in cancer: friend or foe?
RGS proteins | Mechanism/Signaling pathway | Cancers (Reference) |
---|---|---|
RGS2 | MCPIP1-dependent pathway | Breast cancer [84] |
Extracellular signal-regulated kinase 1/2 (ERK1/2) | Prostate cancer [137] | |
RGS4 | Posttranslational regulation | Breast cancer [126] |
RGS6 | SNP (rs2074647) | Bladder cancer [15] |
p53 activation and DNMT1 downregulation | Bladder cancer [104] | |
DNA-damage-induced apoptotic signaling | Breast cancer [105] | |
Phosphatidylinositol 3-kinase signaling | Breast cancer [115] | |
Mitochondrial-dependent pathway | Breast cancer [135] | |
Interaction with SMAD4 | Non-small cell lung cancers [106] | |
A reactive oxygen species-dependent mechanism | - (MEFs)[142] | |
RGS10 | AKT signaling | Ovarian cancer [75] |
Rheb-GTP and mTOR signaling | Ovarian cancer [130] | |
RGS12 | Phosphorylation and SUMOylation of PTEN | Oral cancer [112] |
RGS17 | A target of miR-32 | Breast cancer [128] |
A target of miR-199 | Hepatocellular carcinoma [120] | |
Cyclic AMP-PKA-CREB pathway | Lung and prostate cancer [138] | |
RGS19 | Cell cycle control and AKT signaling | - (HEK293 cells) [131] |
RGS20 | NF-kappaB signaling | Bladder cancer [136] |
PI3K/AKT signaling | Penile cancer [141] |