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Fig. 1 | Cancer Cell International

Fig. 1

From: Hyperglycemia and O-GlcNAc transferase activity drive a cancer stem cell pathway in triple-negative breast cancer

Fig. 1

Pre-menopausal TNBC risk relates to metabolic disease aspects including hyperglycemia. a Conserved facets of metabolic diseases and positive association of pre-menopausal TNBC risk with body-mass index (BMI). b The pathway under study for hyperglycemia driven TNBC tumorigenesis, beginning with the epigenetic regulator tet methylcytosine dioxygenase 1 (TET1). c O-GlcNAc glycosylation is a widespread glucose sensing protein post-translational modification regulated by just two enzymes, the O-GlcNAc transferase (OGT) and the O-GlcNAcase (OGA)

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Cancer Cell International

ISSN: 1475-2867

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