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Fig. 7 | Cancer Cell International

Fig. 7

From: Hyperglycemia and O-GlcNAc transferase activity drive a cancer stem cell pathway in triple-negative breast cancer

Fig. 7

Obesity-associated hyperglycemia drives cellular OGT and O-GlcNAc levels in TNBC tumors. a Timeline for DIO induction and tumor studies. b Glucose in blood samples from control and high-fat diet at 5 and 12 weeks. 12 per group. c–e OGT, TET1, and TARDBP levels, respectively, in TNBC cell line MDA-MB-468-derived tumors harvested from DIO (N = 3) and lean control mice (N = 3). The qRT-PCR analysis of each sample was performed in triplicate and means normalized. f Chemoenzymatic labeling of total O-GlcNAc levels in TNBC tumors isolated from DIO vs. lean mice, N = 1. Mouse weight on diet is shown in Additional file 1: Online Resource 6

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Cancer Cell International

ISSN: 1475-2867

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