Correction: AAA237, an SKP2 inhibitor, suppresses glioblastoma by inducing BNIP3-dependent autophagy through the mTOR pathway

Correction: Cancer Cell International (2024) 24:69 https://doi.org/10.1186/s12935-023-03191-3

In this article [1], the wrong figure appeared as Fig. 1A, Fig. 4F and Fig. 6K; the corrected figures (Figs. 1, 4, 6) are given in this correction.

Fig. 1

AAA237 suppressed viability and inhibited the proliferation of GBM cells in a dose- and time-dependent manner. A After incubation with different concentrations (0, 0.1, 1 and 3 μM) of AAA237 for 48 h, the changes in cell morphology were imaged. Scale bar = 100 μm. IC50 of AAA237 on U251 (B) and LN229 cells (C) at 48 and 72 h. CCK8 assay shows that AAA237 inhibits proliferation of U251 (D) and LN229 (E) cells

Fig. 4

Enrichment analysis and differential gene expression in U251 and LN229 cells treated with AAA237. A Volcano plot of differential expression genes in U251 (up-regulated genes are in red; down-regulated genes are in blue (|log2FC| ≥ 1 and P value ≤ 0.05). B KEGG pathway analysis of differentially expressed genes in U251. C The GO enrichment of BP category in U251. D The GO enrichment of CC category in U251. E The GO enrichment of MF category in U251. F Volcano plot of differential expression genes in LN229 (up-regulated genes are in red; down-regulated genes are in blue (|log2FC| ≥ 1 and P value ≤ 0.05). G KEGG pathway analysis of differentially expressed genes in LN229. H The GO enrichment of BP category in LN229. I The GO enrichment of CC category in LN229. J The GO enrichment of MF category in LN229

Fig. 6

AAA237 induced autophagy through mTOR-mediated pathway regulation. A The representative images of transmission electron microscopy (TEM) of U251 cells after treatment of 3 μM AAA237 for 48 h. Scale bar = 500 nm. B The representative images of transmission electron microscopy (TEM) of LN229 cells after treatment of 3 μM AAA237 for 48 h. Scale bar = 500 nm. C U251 cells with stably expressing mRFP-GFP-LC3 were treated with AAA237 (3 μM) for 48 h and autophagosomes were observed under the fluorescence microscope. Scale bar = 5 μm. D LN229 cells with stably expressing mRFP-GFP-LC3 were treated with AAA237 (3 μM) for 48 h and autophagosomes were observed under the fluorescence microscope. Scale bar = 5 μm. E Expression of p-mTOR, mTOR, P62, Beclin 1, ATG5 and LC3BII in U251 cells was checked by Western blot under treatment with different concentrations of AAA237 (0, 1, 3 and 10 μM) after 24 h, 48 h, 72 h. F Expression of p-mTOR, mTOR, P62, Beclin 1, ATG5 and LC3BII in LN229 cells was checked by Western blot under treatment with different concentrations of AAA237 (0, 1, 3 and 10 μM) after 24 h, 48 h, 72 h. G IC50 of 3-MA on U251. H IC50 of 3-MA on LN229. I The CCK8 assay was used to show 3-MA could reverse the inhibition of cell proliferation caused by AAA237 in U251. J The CCK8 assay was used to show 3-MA could reverse the inhibition of cell proliferation caused by AAA237 in LN229. K After incubation with AAA237 and 3-MA for 48 h, the inhibition of cell proliferation caused by AAA237 was reversed. Scale bar = 100 μm. L, M The EdU-DNA synthesis assay was used to show 3-MA could reverse the inhibition of cell proliferation caused by AAA237 in U251 andLN229. Scale bar = 100 μm. N, O Expression of p-mTOR, mTOR, P62, Beclin 1, ATG5 and LC3BII in U251 cells was checked by Western blot under treatment with AAA237 and 3-MA