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  1. Content type: Primary research

    Long non-coding RNAs (lncRNAs) are a family of non-protein-coding RNAs, which have the ability to influence the chemo-resistance of lung adenocarcinoma (LAC). In this study, we explored the mechanism by which ...

    Authors: Wei Zuo, Wei Zhang, Fei Xu, Jing Zhou and Wei Bai

    Citation: Cancer Cell International 2019 19:240

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  2. Content type: Primary research

    Lung cancer has been a common malignant tumor with a leading cause of morbidity and mortality, current molecular targets are woefully lacking comparing to the highly progressive cancer. The study is designed t...

    Authors: Wenxia Ma, Bin Wang, Yaping Zhang, Ziyue Wang, Dan Niu, Siyu Chen, Zhirong Zhang, Ningning Shen, Weixia Han, Xiaoqin Zhang, Rong Wei and Chen Wang

    Citation: Cancer Cell International 2019 19:239

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  3. Content type: Primary research

    Avoiding the phagocytosis by tumor-associated macrophages (TAMs) is necessary for the growth and metastasis of solid tumors. CD47 binds to the receptor signal-regulatory protein-α (SIRP-α) on the macrophages t...

    Authors: Jingping Yuan, Huihua He, Chuang Chen, Juan Wu, Jie Rao and Honglin Yan

    Citation: Cancer Cell International 2019 19:238

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  4. Content type: Primary research

    The basal transcription/repair factor TFIIH is a ten sub-unit complex essential for RNA polymerase II (RNAP2) transcription initiation and DNA repair. In both these processes TFIIH acts as a DNA helix opener, ...

    Authors: Lise-Marie Donnio, Catherine Miquel, Wim Vermeulen, Giuseppina Giglia-Mari and Pierre-Olivier Mari

    Citation: Cancer Cell International 2019 19:237

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  5. Content type: Primary research

    Hyperoside (Hy) is a plant-derived quercetin 3-d-galactoside that exhibits inhibitory activities on various tumor types. The objective of the current study was to explore Hy effects on cervical cancer cell prolif...

    Authors: Weikang Guo, Hui Yu, Lu Zhang, Xiuwei Chen, Yunduo Liu, Yaoxian Wang and Yunyan Zhang

    Citation: Cancer Cell International 2019 19:235

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  6. Content type: Primary research

    Chemotherapy resistance is one of the main causes of recurrence in colorectal cancer (CRC) patients and leads to poor prognosis. Long noncoding RNAs (lncRNAs) have been reported to regulate chemoresistance. We...

    Authors: Xinke Wang, Zhixian Lan, Juan He, Qiuhua Lai, Xiang Yao, Qingyuan Li, Yongfeng Liu, Huasheng Lai, Chuncai Gu, Qun Yan, Yuxin Fang, Yue Zhang, Aimin Li and Side Liu

    Citation: Cancer Cell International 2019 19:234

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  7. Content type: Primary research

    Immunotherapies that targeting programmed cell death 1 (PD-1) and programmed death-ligand 1 (PD-L1) have obtained prominent success in breast cancer (BC). However, not all the patients benefit from the antibod...

    Authors: Cui Jiang, SunRun Cao, Na Li, Lei Jiang and Tao Sun

    Citation: Cancer Cell International 2019 19:233

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  8. Content type: Primary research

    Methyl-CpG binding domain protein 1 (MBD1), which couples DNA methylation to transcriptional repression, has been implicated in transcriptional regulation, heterochromatin formation, genomic stability, cell cy...

    Authors: Liu Wensheng, Zhang Bo, Hu Qiangsheng, Xu Wenyan, Ji Shunrong, Xu Jin, Ni Quanxing, Yu Xianjun and Xu Xiaowu

    Citation: Cancer Cell International 2019 19:232

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  9. Content type: Primary research

    MicroRNA-200c-3p (miR-200c-3p) has been revealed to be related to renal cell carcinoma (RCC) progression, while the inner mechanisms remain unknown. In our study, we intend to unearth the capability of miR-200...

    Authors: Shuai Li, Ziyu Feng, Xuechong Zhang, Dongyang Lan and Yudong Wu

    Citation: Cancer Cell International 2019 19:231

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  10. Content type: Primary research

    Despite several reports describing the dual role of miR-145 as an oncogene and a tumor suppressor in cancer, not much has been resolved and understood.

    Authors: Siddharth Manvati, Kailash Chandra Mangalhara, Ponnuswamy Kalaiarasan, Rupali Chopra, Gaurav Agarwal, Rakesh Kumar, Sunil Kumar Saini, Monika Kaushik, Ankita Arora, Usha Kumari, Rameshwar Nath Koul Bamezai and Pawan Kumar Dhar

    Citation: Cancer Cell International 2019 19:230

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  11. Content type: Primary research

    The fatality and recurrence rates of bladder cancer (BC) have progressively increased. DNA methylation is an influential regulator associated with gene transcription in the pathogenesis of BC. We describe a co...

    Authors: Liwei Wang, Jiazhong Shi, Yaqin Huang, Sha Liu, Jingqi Zhang, Hua Ding, Jin Yang and Zhiwen Chen

    Citation: Cancer Cell International 2019 19:229

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  12. Content type: Primary research

    Hepatocellular carcinoma (HCC) is one of the most fatal cancers, and its molecular basis needs to be delineated to identify biomarkers for its potential treatment. The purpose of this study was to identify a n...

    Authors: Yong Le, Anna Kan, Qi-Jiong Li, Min-Ke He, Hai-Long Chen and Ming Shi

    Citation: Cancer Cell International 2019 19:228

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  13. Content type: Primary research

    Cervical cancer (CC) is the second most common cancer in less developed countries and the second leading cause of death by cancer in women worldwide. The 99% of CC patients are infected with the Human Papillom...

    Authors: Inocencia Guadalupe Ramírez-López, Adrián Ramírez de Arellano, Luis Felipe Jave-Suárez, Christian David Hernández-Silva, Mariel García-Chagollan, Jorge Hernández-Bello, Edgar I. Lopez-Pulido, José Macias-Barragan, Margarita Montoya-Buelna, José Francisco Muñoz-Valle and Ana Laura Pereira-Suárez

    Citation: Cancer Cell International 2019 19:227

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  14. Content type: Primary research

    Bridging integrator 1 (BIN1) has showed outstanding tumor-suppressive potential via inhibiting c-MYC-mediated tumorigenesis. However, a frequent phosphorylation of c-MYC at Ser-62 site could block the BIN1/c-M...

    Authors: Xiangyu Zhang, Jiali Wang, Yunlong Jia, Tianxu Liu, Mengjie Wang, Wei Lv, Rong Zhang, Juan Shi and Lihua Liu

    Citation: Cancer Cell International 2019 19:226

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  15. Content type: Primary research

    Gastric cancer (GC) is the third-leading cause of cancer-related deaths. We established a prospective database of patients with GC who underwent surgical treatment. In this study, we explored the prognostic si...

    Authors: Jingyue Sun, Yao Long, Xin Peng, Desheng Xiao, Jianhua Zhou, Yongguang Tao and Shuang Liu

    Citation: Cancer Cell International 2019 19:225

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  16. Content type: Primary research

    Cap-dependent mRNA translation is essential for the translation of key oncogenic proteins at optimal levels and is highly regulated by the rate limiting, initiation step in protein synthesis. Eukaryotic Transl...

    Authors: Praveen Kumar Jaiswal, Sweaty Koul, Nallasivam Palanisamy and Hari K. Koul

    Citation: Cancer Cell International 2019 19:224

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  17. Content type: Primary research

    Neoplastic cells promote a hypercoagulable state by the expression of cell surface proteins, such as tissue factor. In BRAFv600 mutated melanoma patients upon BRAF inhibitors, a hypercoagulable state correlates w...

    Authors: Cristian Scatena, Sara Franceschi, Maria Franzini, Chiara Sanguinetti, Nadia Romiti, Laura Caponi, Mario Mandalà, Chiara Maria Mazzanti and Antonio Giuseppe Naccarato

    Citation: Cancer Cell International 2019 19:223

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  18. Content type: Primary research

    Myeloid cell leukaemia 1 (MCL1) is a pro-survival Bcl-2 family protein that plays important roles in cell survival, proliferation, differentiation and tumourigenesis. MCL1 is a fast-turnover protein that is de...

    Authors: Lanqin Wu, Yingying Lin, Jinan Feng, Yuanlin Qi, Xinrui Wang, Qiaofa Lin, Wanyan Shi, Enrun Zheng, Wei Wang, Zhenzhu Hou, Hanbin Lin, Cheng Yu, Yan He, Yan Xu, Hong Yang, Ling Lin…

    Citation: Cancer Cell International 2019 19:222

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  19. Content type: Review

    Renal cell carcinoma (RCC) is not sensitive to conventional radio- and chemotherapies and is at least partially resistant to impairments in cell death-related signaling pathways. The hallmarks of RCC formation...

    Authors: Yongchang Lai, Tao Zeng, Xiongfa Liang, Weizou Wu, Fangling Zhong and Wenqi Wu

    Citation: Cancer Cell International 2019 19:221

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  20. Content type: Primary research

    Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer worldwide and human papillomavirus (HPV) has been increasingly recognized as a pathogenic factor for the initiation and development...

    Authors: Yu Jin, Yuexiu Li, Xin Wang and Ya Yang

    Citation: Cancer Cell International 2019 19:220

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  21. Content type: Primary research

    Lung cancer is one of the most common malignant tumors worldwide. CD36 is a receptor for fatty acids and plays an important role in regulating fatty acid metabolism, which is closely related to tumorigenesis a...

    Authors: Kewei Ni, Dimin Wang, Heyun Xu, Fuyang Mei, Changhao Wu, Zhifang Liu and Bing Zhou

    Citation: Cancer Cell International 2019 19:219

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  22. Content type: Primary research

    Relapse represents the leading cause of death in both child and adult patients with acute lymphoblastic leukemia (ALL). Development of chemo-resistance is ultimately responsible for treatment failure and relap...

    Authors: Haowen Xiao, Yingying Ding, Yang Gao, Li-Mengmeng Wang, Huafang Wang, Lijuan Ding, Xiaoqing Li, Xiaohong Yu and He Huang

    Citation: Cancer Cell International 2019 19:218

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  23. Content type: Primary research

    Melanoma is an extremely aggressive malignant skin tumor with high mortality. Many types of long noncoding RNAs and microRNAs have been reported to be associated with the oncogenesis of melanoma. However, a no...

    Authors: Fei Ding, Jindong Lai, Yang Gao, Genhui Wang, Jingwen Shang, Daojun Zhang and Shumao Zheng

    Citation: Cancer Cell International 2019 19:217

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  24. Content type: Primary research

    The long non-coding RNA H19 plays critical roles in cancer occurrence, development, and progression. The present study is for the first time to evaluate the association of genetic variations in the H19 promoter r...

    Authors: Wenyan Qin, Xiaodong Wang, Yilin Wang, Yalun Li, Qiuchen Chen, Xiaoyun Hu, Zhikun Wu, Pengfei Zhao, Shanqiong Li, Haishan Zhao, Weifan Yao, Jian Ding, Minjie Wei and Huizhe Wu

    Citation: Cancer Cell International 2019 19:215

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  25. Content type: Primary research

    Gene expression profiles have demonstrated that miR-21 expression is altered in almost all types of cancers and it has been classified as an oncogenic microRNA. Persistent HPV infection is the main etiologic a...

    Authors: Sacnite del Mar Díaz-González, Eduardo Daniel Rodríguez-Aguilar, Angélica Meneses-Acosta, Viviana Valadez-Graham, Jessica Deas, Claudia Gómez-Cerón, Carlos Alberto Tavira-Montalván, Alitzel Arizmendi-Heras, Julián Ramírez-Bello, Mario Enrique Zurita-Ortega, Berenice Illades-Aguiar, Marco Antonio Leyva-Vázquez, Gloria Fernández-Tilapa, Víctor Hugo Bermúdez-Morales, Vicente Madrid-Marina, Mauricio Rodríguez-Dorantes…

    Citation: Cancer Cell International 2019 19:214

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  26. Content type: Primary research

    Gastric cancer (GC) is one of the most common malignant tumours with high mortality and metastasis rates. E2F3, miR-125a and DKK3 have been reported to be involved in various cancer types, but their detailed r...

    Authors: Yihua Pei, Zhiteng Tang, Minjing Cai, Qin Yao, Bozhen Xie and Xin Zhang

    Citation: Cancer Cell International 2019 19:212

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  27. Content type: Primary research

    CircRNA myosin light chain kinase (circRNA MYLK) has been shown to promote the progression of various tumor diseases. The purpose of this study was to explore the potential molecular mechanism of circMYLK in h...

    Authors: Zhiqin Li, Yushu Hu, Qinglei Zeng, Hongyan Wang, Jingya Yan, Hua Li and Zujiang Yu

    Citation: Cancer Cell International 2019 19:211

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  28. Content type: Primary research

    Long non-coding RNAs play an important role in breast cancer. Even with adjuvant hormone therapy, patients with estrogen receptor positive breast cancer can present with recurrences and distant metastases. We ...

    Authors: Sheng Huang, Yayun Chi, Weiru Chi, Rong Guo, Yonghui Su, Jingyan Xue, Shaoqiang Zhou, Jiankui Wang, Zhuangqing Yang, Jianyun Nie, Zhimin Shao, Dedian Chen and Jiong Wu

    Citation: Cancer Cell International 2019 19:210

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  29. Content type: Minireview

    The recent advent of immunomodulatory therapies into the clinic has demanded the identification of innovative predictive biomarkers to identify patients most likely to respond to immunotherapy and support the ...

    Authors: Francesca Galuppini, Carlo Alberto Dal Pozzo, Jutta Deckert, Fotios Loupakis, Matteo Fassan and Raffaele Baffa

    Citation: Cancer Cell International 2019 19:209

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  30. Content type: Primary research

    Abnormal expressions of long noncoding RNAs (lncRNAs) are very common in clear cell renal cell carcinoma (ccRCC), and some of these have been reported to be highly correlated with prognosis of ccRCC patients.

    Authors: Wen Jiang, Qing Guo, Chenghe Wang and Yu Zhu

    Citation: Cancer Cell International 2019 19:208

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  31. Content type: Review

    Cancer is one of the leading causes of death around the world and although the different clinical approaches have helped to increase survival rates, incidence is still high and so its mortality. Chemotherapy i...

    Authors: Carolina Escardó Pereyra, Rafael Ferreira Dantas, Sabrina Baptista Ferreira, Luciano Pinho Gomes and Floriano Paes Silva-Jr

    Citation: Cancer Cell International 2019 19:207

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  32. Content type: Primary research

    Micronuclei (MNi) are extensively used to evaluate genotoxic effects and chromosome instability. However, the roles of kinetochore of MN in mitosis have not been completely addressed.

    Authors: Erkang Jiang, Lianping Wei, Fang Tao, Mei Yu, Shu Wang, Xiuhong Zhou, Daxiang Li and Zhongwen Xie

    Citation: Cancer Cell International 2019 19:206

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  33. Content type: Primary research

    Kinesin family member 26B (KIF26B) is unveiled acted as important role in many solid tumors, however, the function of KIF26B in hepatocellular carcinoma (HCC) is unclear.

    Authors: Hua Li, Shen Shen, Xiaolong Chen, Zhigang Ren, Zhiqin Li and Zujiang Yu

    Citation: Cancer Cell International 2019 19:205

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  34. Content type: Primary research

    Although the most thyroid carcinoma patients have good prognosis, around 20% of papillary thyroid carcinoma (PTC) patients have a high rate of metastasis and recurrence after routine treatment, which causes hi...

    Authors: Longyan Yang, Rongxin Sun, Yan Wang, Ying Fu, Yuanyuan Zhang, Zhaohui Zheng, Zhili Ji and Dong Zhao

    Citation: Cancer Cell International 2019 19:204

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  35. Content type: Primary research

    Thioredoxin reductase 1 (TXNRD1) is an antioxidant enzyme reportedly overexpressed in hepatocellular carcinoma (HCC); however, the detailed function and mechanisms of TXNRD1 in HCC remain obscure. In this study, ...

    Authors: Shengni Hua, Yingyao Quan, Meixiao Zhan, Huaxin Liao, Yong Li and Ligong Lu

    Citation: Cancer Cell International 2019 19:203

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  36. Content type: Primary research

    Long noncoding RNA (lncRNA) has been implicated in numerous tumors, including pancreatic cancer (PC). However, the precise cellular roles and molecular mechanisms of lncRNA DIO3OS on PC development remains to ...

    Authors: Kang Cui, Shuiling Jin, Yabing Du, Junlin Yu, Han Feng, Qingxia Fan and Wang Ma

    Citation: Cancer Cell International 2019 19:202

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  37. Content type: Primary research

    To explore the role of lysophosphatidic acid receptor 1 (LPAR1) and its correlation with the PI3K/AKT pathway in the development of intratumoral heterogeneity (ITH) in human ovarian serous cystadenocarcinoma (...

    Authors: Ran Cui, Guangming Cao, Huimin Bai and Zhenyu Zhang

    Citation: Cancer Cell International 2019 19:201

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  38. Content type: Primary research

    miRNA 106b~25 cluster were demonstrated to be an oncogene. In previous study, we had analyzed the diagnostic significance of miRNA 106b~25 based on its carcinogenesis effect. The significance of miRNA 106b~25 ...

    Authors: Fangxuan Li, Jinchao Huang, Juntian Liu, Wengui Xu and Zhiyong Yuan

    Citation: Cancer Cell International 2019 19:200

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  39. Content type: Primary research

    Ovarian cancer is often accompanied by the production of ascites, and patients with repeated ascites are associated with chemotherapy resistance. The previous study confirmed that the ovarian cancer patients w...

    Authors: Jing Tang, Jiang Zhu, Yuguang Ye, Yu Liu, Yan He, Lei Zhang, Dai Tang, Cong Qiao, Xinxin Feng, Junyi Li, Yanni Kan, Xiaobo Li, Xiaoming Jin and Dan Kong

    Citation: Cancer Cell International 2019 19:199

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  40. Content type: Primary research

    MicroRNAs (miRNAs) play a pivotal role in hepatocellular carcinoma (HCC) progression and have been confirmed to participate in the carcinogenesis and development of HCC. However, the relationship between miR-4...

    Authors: Yixi Zhang, Zebin Zhu, Shanzhou Huang, Qiang Zhao, Changjun Huang, Yunhua Tang, Chengjun Sun, Zhiheng Zhang, Linhe Wang, Huadi Chen, Maogen Chen, Weiqiang Ju and Xiaoshun He

    Citation: Cancer Cell International 2019 19:198

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  41. Content type: Primary research

    Mitofusin 2 (Mfn2) is outer membrane protein, as the inhibitor of Ras protein. This study aimed to investigate the effect of Mfn2 on cell proliferation, and cell-cycle in Hela cervical carcinoma cell lines.

    Authors: Xiaowen Liu, Jun Sun, Ping Yuan, Kangquan Shou, Yuanhong Zhou, Wenqi Gao, Jin She, Jun Hu, Jun Yang and Jian Yang

    Citation: Cancer Cell International 2019 19:197

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  42. Content type: Primary research

    Accumulating evidence shows that circular RNAs (circRNAs) plays vital roles in tumor progression. However, the biological functions of circRNAs in laryngeal squamous cell carcinoma (LSCC) metastasis is still u...

    Authors: Jian-Xing Wang, Yan Liu, Xin-Ju Jia, Shu-Xia Liu, Jin-Hui Dong, Xiu-Min Ren, Ou Xu, Hai-Zhong Zhang, Hui-Jun Duan and Chun-Guang Shan

    Citation: Cancer Cell International 2019 19:196

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  43. Content type: Primary research

    AZD7762 is a checkpoint kinase 1 (Chk 1) inhibitor, which has been reported to sensitize many tumor cells to DNA damage. However, whether AZD7762 could sensitize osteosarcoma cells to chemotherapy cisplatin ha...

    Authors: Jian Zhu, Hanhui Zou, Wei Yu, Yuluan Huang, Bing Liu, Tao Li, Chengzhen Liang and Huimin Tao

    Citation: Cancer Cell International 2019 19:195

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  44. Content type: Primary research

    Breast cancer, the most common invasive cancer of women, is a malignant neoplasm and the second main cause of cancer death. Resistance to paclitaxel (Taxol), one of the frequently used chemotherapy agents for ...

    Authors: Lu Hou, Yi Zhao, Guo-qing Song, Ying-han Ma, Xiao-hu Jin, Si-li Jin, Yi-han Fang and Yi-chong Chen

    Citation: Cancer Cell International 2019 19:193

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  45. Content type: Primary research

    Carcinoma-associated fibroblasts (CAFs) are dominant components of tumor microenvironment, which has been reported to promote development, progression, and metastasis of cancer. However, the role of CAFs durin...

    Authors: Rongsheng Zhang, Fan Qi, Shengli Shao, Geng Li and Yongdong Feng

    Citation: Cancer Cell International 2019 19:192

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  46. Content type: Primary research

    Doxorubicin (DOX) is one of the most important anticancer agents used in treating breast cancer. However, chronic cardiotoxicity and multidrug resistance limit the chemotherapeutic use of DOX.

    Authors: Hamdan S. Al-malky, Abdel-Moneim M. Osman, Zoheir A. Damanhouri, Huda M. Alkreathy, Jumana Y. Al Aama, Wafaa S. Ramadan, Ali A. Al Qahtani and Hadiah B. Al Mahdi

    Citation: Cancer Cell International 2019 19:191

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