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  1. Long non-coding RNAs are RNAs longer than 200 bps that do not encode any proteins and are able to alter gene expression by acting on different steps of regulation, including DNA methylation and chromatin struc...

    Authors: Lorena Buono, Concetta Iside, Antonia De Matteo, Pio Stellato, Giuliana Beneduce, Roberta Penta de Vera d’Aragona, Rosanna Parasole, Marco Salvatore, Giovanni Smaldone and Peppino Mirabelli
    Citation: Cancer Cell International 2022 22:373
  2. It is unclear which core events drive the malignant progression of gliomas. Earlier studies have revealed that the embryonic stem (ES) cell/early PGC state is associated with tumourigenicity. This study was de...

    Authors: Zhan Ma, Fengyu Zhang, Ji Xiong, Haishi Zhang, Hui-Kuan Lin and Chunfang Liu
    Citation: Cancer Cell International 2022 22:371
  3. Viruses are completely dependent on host cell machinery for their reproduction. As a result, factors that influence the state of cells, such as signaling pathways and gene expression, could determine the outco...

    Authors: Sara Shayan, Arash Arashkia and Kayhan Azadmanesh
    Citation: Cancer Cell International 2022 22:370
  4. Intercellular communication plays an important role in cancer initiation and progression through direct contact and indirect interactions, such as via secretory molecules. Cancer-associated fibroblasts (CAFs) ...

    Authors: Yutaka Naito, Yusuke Yoshioka and Takahiro Ochiya
    Citation: Cancer Cell International 2022 22:367
  5. Hepatocellular carcinoma (HCC) is one of the deadliest cancers and is mainly developed from chronic liver diseases such as hepatitis-B infection-associated liver cirrhosis (LC). The progression from LC to HCC ...

    Authors: Michelle Junyi He, Wenjun Pu, Xi Wang, Xiaoni Zhong, Dong Zhao, Zhipeng Zeng, Wanxia Cai, Jiayi Liu, Jianrong Huang, Donge Tang and Yong Dai
    Citation: Cancer Cell International 2022 22:366
  6. In recent decades, the advent of immune-based therapies, most notably Chimeric antigen receptor (CAR)-T cell therapy has revolutionized cancer treatment. The promising results of numerous studies indicate that...

    Authors: Maysoon Al-Haideri, Santalia Banne Tondok, Salar Hozhabri Safa, Ali Heidarnejad maleki, Samaneh Rostami, Abduladheem Turki Jalil, Moaed E. Al-Gazally, Fahad Alsaikhan, Jasur Alimdjanovich Rizaev, Talar Ahmad Merza Mohammad and Safa Tahmasebi
    Citation: Cancer Cell International 2022 22:365
  7. Radiotherapy is one of the essential treatment modalities for nasopharyngeal carcinoma (NPC), however, radioresistance still poses challenges. Three-dimensional (3D) tumor culture models mimic the in vivo grow...

    Authors: Yanhua Fang, Shanshan Liang, Jianong Gao, Zhe Wang, Cheng Li, Ruoyu Wang and Weiting Yu
    Citation: Cancer Cell International 2022 22:364
  8. Although people are more and more aware of the cardiotoxicity caused by immune checkpoint inhibitors (ICIs) in the treatment of lung cancer, its incidence rate has not been systematically analyzed. This study ...

    Authors: Xiao-Tong Zhang, Nan Ge, Zi-Jian Xiang and Tao Liu
    Citation: Cancer Cell International 2022 22:363
  9. Transarterial chemoembolization (TACE) has been shown to prolong survival in patients with unresectable hepatocellular carcinoma (HCC); however, the long-term survival remains dismal. Targeting macrophage and ...

    Authors: Zhiqiang Tian, Xiaojuan Hou, Wenting Liu, Changchun Shao, Lu Gao, Jinghua Jiang, Li Zhang, Zhipeng Han and Lixin Wei
    Citation: Cancer Cell International 2022 22:362
  10. Gynecological cancer is one of the most severe diseases that threaten the lives and health of women worldwide. Its incidence rate increases with each passing year and becomes more prevalent among young people....

    Authors: Jia-Jia Zhang, Wei Liu, Guo-Zhen Xing, Li Xiang, Wen-Ming Zheng and Zhen-Ling Ma
    Citation: Cancer Cell International 2022 22:361
  11. Nasopharyngeal carcinoma (NPC) is prevailing in Southern China, characterized by distinct geographical distribution. Aimed to predict the overall survival (OS) of patients with nasopharyngeal carcinoma, this s...

    Authors: Siwei Miao, Haike Lei, Xiaosheng Li, Wei Zhou, Guixue Wang, Anlong Sun, Ying Wang and Yongzhong Wu
    Citation: Cancer Cell International 2022 22:360
  12. Glioblastoma (GBM) is the most common primary malignant tumor in the brain, and its robust proliferation and invasion abilities reduce the survival time of patients. Circular RNAs (circRNAs) play an essential ...

    Authors: Jiang Zhou, Chengbin Wang, Yingliang Liu, Daming Cui, Zhenlin Wang, Yang Jiang and Liang Gao
    Citation: Cancer Cell International 2022 22:359
  13. Tumor suppressor CYLD dysfunction by loss of its expression, triggers malignant transformation, especially drug resistance and tumor invasion/metastasis. Although loss of CYLD expression is significantly assoc...

    Authors: Ayumi Kanemaru, Satoru Shinriki, Mimi Kai, Kanae Tsurekawa, Kazuya Ozeki, Shota Uchino, Naoki Suenaga, Kou Yonemaru, Shunsuke Miyake, Takeshi Masuda, Ryusho Kariya, Seiji Okada, Hisashi Takeshita, Yuki Seki, Hiromu Yano, Yoshihiro Komohara…
    Citation: Cancer Cell International 2022 22:358
  14. Due to the rarity of PBL and the lack of large-scale studies, the prognostic value of IPI in PBL was controversial. Especially in the rituximab era, the ability of IPI to stratify prognosis in patients receivi...

    Authors: Kexin Feng, Shuangtao Zhao, Qingyao Shang, Guangdong Qiao, Jiaxiang Liu, Chenxuan Yang, Ya Wei, Yalun Li, Fei Ren, Lixue Xuan, Xiang Wang and Xin Wang
    Citation: Cancer Cell International 2022 22:357
  15. The distinctive properties and high activity of calcium titanate nanoparticles (CaTiO3-NPs) increase their use in many products. However, the cytotoxic and genotoxic effects of CaTiO3-NPs in human cancer cell lin...

    Authors: Hanan R. H. Mohamed, Maria M. H. Ibrahim and Ayman Diab
    Citation: Cancer Cell International 2022 22:355
  16. Recent technological advances in nanoscience and material designing have led to the development of point-of-care devices for biomolecule sensing and cancer diagnosis. In situ and portable sensing devices for b...

    Authors: Muhammad Javed Iqbal, Zeeshan Javed, Jesús Herrera-Bravo, Haleema Sadia, Faiza Anum, Shahid Raza, Arifa Tahir, Muhammad Naeem Shahwani, Javad Sharifi-Rad, Daniela Calina and William C. Cho
    Citation: Cancer Cell International 2022 22:354
  17. N6-methyladenosine (m6A) is the most common posttranscriptional modification of RNA and plays critical roles in human cancer progression. However, the biological function of m6A methylation requires further st...

    Authors: Wenyi Shen, Juan Pu, Zhi Zuo, Shanye Gu, Jing Sun, Bing Tan, Lili Wang, Jianmeng Cheng and Yangsong Zuo
    Citation: Cancer Cell International 2022 22:353
  18. Head and neck squamous cell carcinoma (HNSCC) is the most common malignant tumor of the head and neck. We identified cancer-specific genes in HNSCC and focused on DKK3 expression. DKK3 gene codes two isoforms ...

    Authors: Naoki Katase, Shin-ichiro Nishimatsu, Akira Yamauchi, Shinji Okano and Shuichi Fujita
    Citation: Cancer Cell International 2022 22:352
  19. Asymmetric dimethylarginine (ADMA), which is significantly elevated in the plasma of cancer patients, is formed via intracellular recycling of methylated proteins and serves as a precursor for resynthesis of a...

    Authors: Yi-Ling Chen, AKaychia T. Lowery, Samuel Lin, Ameae M. Walker and Kuan-Hui E. Chen
    Citation: Cancer Cell International 2022 22:351
  20. Human epidermal growth factor receptor 2 (HER2) positive breast carcinomas due to HER2 amplification are associated with aggressive behavior and a poor prognosis. Anti-HER2-targeted therapies are widely used to t...

    Authors: Laura Morsberger, Aparna Pallavajjala, Patty Long, Melanie Hardy, Rebecca Park, Rebecca Parish, Azin Nozari and Ying S. Zou
    Citation: Cancer Cell International 2022 22:350
  21. We investigate the correlation between programmed cell death-ligand 1 (PD-L1) and tumor-associated immune cell (TAIC) density in small-cell neuroendocrine carcinoma of the uterine cervix (SCNEC) and their corr...

    Authors: Xiaoying Sun, Lili Liu, Ting Wan, Qidan Huang, Jieping Chen, Rongzhen Luo and Jihong Liu
    Citation: Cancer Cell International 2022 22:348
  22. Genes related to the SWItch/sucrose nonfermentable (SWI/SNF) chromatin remodeling complex are frequently mutated across cancers. SWI/SNF-mutant tumors are vulnerable to synthetic lethal inhibitors. However, th...

    Authors: Yue Li, Xinhua Yang, Weijie Zhu, Yuxia Xu, Jiangjun Ma, Caiyun He and Fang Wang
    Citation: Cancer Cell International 2022 22:347
  23. Prostate cancer (PCa) is currently the major malignancy in men. It is becoming increasingly clear that competitive endogenous RNA (ceRNA) regulation networks are important in a wide variety of cancers. Neverth...

    Authors: Qinyu Li, Bingliang Chen, Guoda Song, Kai Zeng, Xin Chen, Jianping Miao, Xianglin Yuan, Jihong Liu, Zhihua Wang and Bo Liu
    Citation: Cancer Cell International 2022 22:346
  24. Head and neck squamous cell cancer (HNSCC) is a common malignant cancer. We aimed to explore prognostic cuproptosis-related lncRNAs (CRLs) and prognostic risk models for HNSCC.

    Authors: Xiajing Liu, Wenwei Cheng, Heqing Li and Yexun Song
    Citation: Cancer Cell International 2022 22:345
  25. Intestinal alkaline sphingomyelinase (alk-SMase) generates ceramide and inactivates platelet-activating factor associated with digestion and inhibition of cancer. There is few study to analyze the correlated f...

    Authors: Jiang Zhu, Lingqi Wang, Zhongwu Guo, Tao Zhang and Ping Zhang
    Citation: Cancer Cell International 2022 22:344

    The Correction to this article has been published in Cancer Cell International 2022 22:372

  26. Prohibitins (PHBs) are a class of highly evolutionarily conserved proteins that widely distribute in prokaryotes and eukaryotes. PHBs function in cell growth and proliferation or differentiation, regulating me...

    Authors: Linda Oyang, Jian Li, Xianjie Jiang, Jinguan Lin, Longzheng Xia, Lixia Yang, Shiming Tan, Nayiyuan Wu, Yaqian Han, Yiqing Yang, Xia Luo, Jinyun Li, Qianjin Liao, Yingrui Shi and Yujuan Zhou
    Citation: Cancer Cell International 2022 22:343
  27. miR-16-5p is microRNA with important roles in the development of diverse malignancies including neuroblastoma, osteosarcoma, hepatocellular carcinoma, cervical cancer, breast cancer, brain tumors, gastrointest...

    Authors: Soudeh Ghafouri-Fard, Tayyebeh Khoshbakht, Bashdar Mahmud Hussen, Sara Tharwat Abdullah, Mohammad Taheri and Mohammad Samadian
    Citation: Cancer Cell International 2022 22:342
  28. Metastasis is the leading cause of death in colorectal cancer (CRC) patients, and the liver is the most common site of metastasis. Tumor cell metastasis can be thought of as an invasion-metastasis cascade and ...

    Authors: Yaru Niu, Wenwei Yang, Haili Qian and Yongkun Sun
    Citation: Cancer Cell International 2022 22:341
  29. Pancreatic cancer is one of the most lethal disease with highly fatal and aggressive properties. Lymph node ratio (LNR), the ratio of the number of metastatic lymph nodes to the total number of examined lymph ...

    Authors: Cheng Qin, Tianhao Li, Yuanyang Wang, Bangbo Zhao, Zeru Li, Tianyu Li, Xiaoying Yang, Yutong Zhao and Weibin Wang
    Citation: Cancer Cell International 2022 22:340
  30. Transcription factors (TFs) are essential for many biological processes and regulate the expression of several genes. This study’s objective was to analyze the abnormalities in TF expression, their impact on p...

    Authors: Manizheh Sajadi, Mohammad Fazilti, Habibollah Nazem, Mohammad Mahdevar and Kamran Ghaedi
    Citation: Cancer Cell International 2022 22:339

    The Correction to this article has been published in Cancer Cell International 2023 23:53

  31. Non-small cell lung cancer (NSCLC) accounts for more than 85% of the total cases with lung cancer. NSCLC is characterized by easy metastasis, which often spreads to bones, brains and livers. RNA-binding motif ...

    Authors: Shan Cong, Xin Di, Ranwei Li, Yingshu Cao, Xin Jin, Chang Tian, Min Zhao and Ke Wang
    Citation: Cancer Cell International 2022 22:338
  32. Long non-coding RNAs (lncRNAs) are involved in a variety of mechanisms related to tumorigenesis by functioning as oncogenes or tumor-suppressors or even harboring oncogenic and tumor-suppressing effects; repre...

    Authors: Mohammad Amin Kerachian and Marjan Azghandi
    Citation: Cancer Cell International 2022 22:337
  33. Ovarian cancer (OC) is characterized by a low response rate and high frequency of resistance development to currently available treatments. The therapeutic potential of histone methyltransferase DOT1L inhibito...

    Authors: Elena Alexandrova, Jessica Lamberti, Domenico Memoli, Claudia Quercia, Viola Melone, Francesca Rizzo, Roberta Tarallo, Giorgio Giurato, Giovanni Nassa and Alessandro Weisz
    Citation: Cancer Cell International 2022 22:336
  34. Colorectal cancer (CRC) is a gastrointestinal tumor that develops from the colon, rectum, or appendix. The prognosis of CRC patients especially those with metastatic lesions remains unsatisfactory. Although va...

    Authors: Shirin Azizidoost, Ava Nasrolahi, Farhoodeh Ghaedrahmati, Bartosz Kempisty, Paul Mozdziak, Klaudia Radoszkiewicz and Maryam Farzaneh
    Citation: Cancer Cell International 2022 22:335
  35. Pancreatic ductal adenocarcinoma (PDAC) is one of the leading cancers worldwide and has a poor survival, with a 5-year survival rate of only 8.5%. In this study we investigated altered DNA methylation associat...

    Authors: Ankita Chatterjee, Akash Bararia, Debopriyo Ganguly, Pronoy Kanti Mondal, Paromita Roy, Sudeep Banerjee, Shibajyoti Ghosh, Sumit Gulati, Supriyo Ghatak, Bitan Kumar Chattopadhay, Priyadarshi Basu, Aniruddha Chatterjee and Nilabja Sikdar
    Citation: Cancer Cell International 2022 22:334
  36. Hepatocellular carcinoma (HCC) is the most common neoplasm among primary liver malignancies, accounting for 70%–85% of total liver cancer cases worldwide. It is also the second-leading cause of cancer-related ...

    Authors: Aya M. Hussein, Nadia M. El-Beih, Menha Swellam and Enas A. El-Hussieny
    Citation: Cancer Cell International 2022 22:333
  37. To evaluate the efficacy of autologous hematopoietic stem cell transplantation (auto-HSCT) in patients with favorable-risk acute myeloid leukemia in first remission.

    Authors: Juan Chen, Li Liu, Runzhi Ma, Aiming Pang, Donglin Yang, Xin Chen, Jialin Wei, Yi He, Rongli Zhang, Weihua Zhai, Qiaoling Ma, Erlie Jiang, Mingzhe Han, Jiaxi Zhou and Sizhou Feng
    Citation: Cancer Cell International 2022 22:332
  38. To summarize the impact of radiotherapy (RT) and chemotherapy delays on patients with nasopharyngeal carcinoma (NPC) during the COVID-19 pandemic.

    Authors: Cheng-Long Huang, Xue-Liang Fang, Yan-Ping Mao, Rui Guo, Wen-Fei Li, Si-Si Xu, Jun Ma, Lei Chen and Ling-Long Tang
    Citation: Cancer Cell International 2022 22:331
  39. Long non-coding RNA X-inactive specific transcript (XIST) regulates the progression of a variety of tumors, including osteosarcoma. Bone marrow mesenchymal stem cells (BMSCs) can be recruited into osteosarcoma...

    Authors: Guanghui Zhu, Yu Xia, Ziyue Zhao, Aoyu Li, Hui Li and Tao Xiao
    Citation: Cancer Cell International 2022 22:330
  40. We identified here mechanism by which hAECs exert their anti-cancer effects. We showed that vaccination with live hAEC conferred effective protection against murine colon cancer and melanoma but not against br...

    Authors: Mohammad-Reza Bolouri, Roya Ghods, Kayhan Zarnani, Sedigheh Vafaei, Reza Falak and Amir-Hassan Zarnani
    Citation: Cancer Cell International 2022 22:329
  41. Cuproptosis (copper death) is a recently found cell death type produced by copper iron; nonetheless, the properties of cuproptosis molecular subtypes and possible involvement of cuproptosis-related genes (CRGs...

    Authors: Jingjing Zhang, Miao Lu, Haoya Xu, Fang Ren and Liancheng Zhu
    Citation: Cancer Cell International 2022 22:328
  42. Oncoviruses, known as cancer-causing viruses, are typically involved in cancer progression by inhibiting tumor suppressor pathways and uncontrolled cell division. Myeloid cells are the most frequent population...

    Authors: Azin Aghamajidi, Pooya Farhangnia, Salar Pashangzadeh, Amirmasoud Rayati Damavandi and Reza Jafari
    Citation: Cancer Cell International 2022 22:327
  43. Ferroptosis is an iron-dependent mode of cell death that could be induced by erastin and exert antitumor effects. However, the clinical and biological roles of ferroptosis-related gene (FRG) signature and the ...

    Authors: Bibo Fu, Ruonan Shao, Huizhong Wang, Guanjun Chen, Shenrui Bai and Hua Wang
    Citation: Cancer Cell International 2022 22:326
  44. The Cyclin-dependent kinase (CDK) class of serine/threonine kinases has crucial roles in the regulation of cell cycle transition and is mainly involved in the pathogenesis of cancers. The expression of CDKs is...

    Authors: Soudeh Ghafouri-Fard, Tayyebeh Khoshbakht, Bashdar Mahmud Hussen, Peixin Dong, Nikolaus Gassler, Mohammad Taheri, Aria Baniahmad and Nader Akbari Dilmaghani
    Citation: Cancer Cell International 2022 22:325
  45. Secreted phosphoprotein 1 (SPP1), an extracellular secreted glycol phosphoprotein, is closely related to tumor biologies, such as proliferation, migration, and invasion. However, the role and biological functi...

    Authors: Xuan Yi, Linlin Luo, Yanzhen Zhu, Hong Deng, Huitian Liao, Yang Shen and Yan Zheng
    Citation: Cancer Cell International 2022 22:324

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