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  1. Content type: Primary research

    Tyrosine kinase inhibitors (TKIs) have gained much attention in recent years as targeted agents for the treatment of a wide range of human cancers. We have investigated the effect of the TKIs gefitinib and van...

    Authors: Mattias K Andersson and Pierre Åman

    Citation: Cancer Cell International 2008 8:1

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  2. Content type: Primary research

    Glucocorticoids (GC's) play an integral role in treatment strategies designed to combat various forms of hematological malignancies. GCs also are powerful inhibitors of the immune system, through regulation of...

    Authors: Aaron L Miller, Spogmai Komak, M Scott Webb, Edward H Leiter and E Brad Thompson

    Citation: Cancer Cell International 2007 7:18

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  3. Content type: Primary research

    The CXCR4/CXCL12 chemokine axis may play a critical role in guiding CXCR4+ circulating malignant cells to organ specific locations that actively secrete its ligand CXCL12 (SDF-1) such as bone, brain, liver, an...

    Authors: Sebastian Di Cesare, Jean-Claude Marshall, Bruno F Fernandes, Patrick Logan, Emilia Antecka, Vasco Bravo Filho and Miguel N Burnier Jr

    Citation: Cancer Cell International 2007 7:17

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  4. Content type: Primary research

    Integrins are transmembrane adhesion receptors that provide the physical link between the actin cytoskeleton and the extracellular matrix. It has been well established that integrins play a major role in vario...

    Authors: Sophia Havaki, Mirsini Kouloukoussa, Kawther Amawi, Yiannis Drosos, Leonidas D Arvanitis, Nikos Goutas, Dimitrios Vlachodimitropoulos, Stamatis D Vassilaros, Eleni Z Katsantoni, Irene Voloudakis-Baltatzis, Vassiliki Aleporou-Marinou, Christos Kittas and Evangelos Marinos

    Citation: Cancer Cell International 2007 7:16

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  5. Content type: Primary research

    Methylation-mediated silencing of genes is one epigenetic mechanism implicated in cancer. Studies regarding the role of modulation of gene expression utilizing inhibitors of DNA methylation, such as decitabine...

    Authors: Khaldoun Al-Romaih, Gino R Somers, Jane Bayani, Simon Hughes, Mona Prasad, Jean-Claude Cutz, Hui Xue, Maria Zielenska, Yuzhuo Wang and Jeremy A Squire

    Citation: Cancer Cell International 2007 7:14

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  6. Content type: Primary research

    Mutational inactivation of the von Hippel-Lindau (VHL) tumor suppressor gene has been linked to hereditary as well as sporadic clear cell renal carcinomas. The product of the VHL gene, pVHL, acts to target hyp...

    Authors: Michael D Hughes, Erilda Kapllani, Ashlynn E Alexander, Robert D Burk and Alan R Schoenfeld

    Citation: Cancer Cell International 2007 7:13

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  7. Content type: Primary research

    Uncovering the molecular mechanism underlying expansion of hematopoietic stem and progenitor cells is critical to extend current therapeutic applications and to understand how its deregulation relates to leuke...

    Authors: Oswaldo Keith Okamoto, Ana Carolina SR Carvalho, Luciana C Marti, Ricardo Z Vêncio and Carlos A Moreira-Filho

    Citation: Cancer Cell International 2007 7:11

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  8. Content type: Primary research

    Pancratistatin (PST), a compound extracted from an Amaryllidaceae (AMD) family plant, has been shown to specifically induce apoptosis in cancer cells with no/minimal toxic effect on normal cells. A systematic syn...

    Authors: Carly Griffin, Natasha Sharda, Divya Sood, Jerald Nair, James McNulty and Siyaram Pandey

    Citation: Cancer Cell International 2007 7:10

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  9. Content type: Review

    For over 30 years, stem cells have been used in the replenishment of blood and immune systems damaged by the cancer cells or during treatment of cancer by chemotherapy or radiotherapy. Apart from their use in ...

    Authors: Jayesh Sagar, Boussad Chaib, Kevin Sales, Marc Winslet and Alexander Seifalian

    Citation: Cancer Cell International 2007 7:9

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  10. Content type: Primary research

    Most cancers express elevated protease levels which contribute to certain aspects of tumor behavior such as growth, metastatic spread, and angiogenesis. Elevation of the cathepsins of the cysteine protease fam...

    Authors: Zhen Yang and James L Cox

    Citation: Cancer Cell International 2007 7:8

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  11. Content type: Primary research

    Fish oil is known to protect from many types of cancers of the colon, liver, breast, prostate and lung [13]. The objective of the present study was to evaluate the role of fish oil [Maxepa, supplemented at a dos...

    Authors: Sangita Manna, Tridib Chakraborty, Suresh Damodaran, Kartick Samanta, Basabi Rana and Malay Chatterjee

    Citation: Cancer Cell International 2007 7:6

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  12. Content type: Primary research

    The pharmacologic modulatory effects of the antibiotic, tunicamycin (TM), on multidrug-resistant human UWOV2 ovarian cancer cells are reported. The UWOV2 cell line was derived from a cystadenocarcinoma in a pa...

    Authors: Donavon C Hiss, Gary A Gabriels and Peter I Folb

    Citation: Cancer Cell International 2007 7:5

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  13. Content type: Primary research

    Glucocorticoids are frequently used as a primary chemotherapeutic agent in many types of human lymphoid malignancies because they induce apoptosis through activation of the glucocorticoid receptor, with subseq...

    Authors: Aaron L Miller, Anna S Garza, Betty H Johnson and E Brad Thompson

    Citation: Cancer Cell International 2007 7:3

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  14. Content type: Review

    Cancer begins with multiple cumulative epigenetic and genetic alterations that sequencially transform a cell, or a group of cells in a particular organ. The early genetic events might lead to clonal expansion ...

    Authors: Gabriel D Dakubo, John P Jakupciak, Mark A Birch-Machin and Ryan L Parr

    Citation: Cancer Cell International 2007 7:2

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  15. Content type: Primary research

    Prolactinoma is the most frequent pituitary tumor in humans. The dopamine D2 receptor agonist bromocriptine has been widely used clinically to treat human breast tumor and prolactinoma through inhibition of hyper...

    Authors: Yan-Nian Jiang, Yi-Hung Li, Meng-Wei Ke, Ting-Yu Tseng, Yueh-Bih Tang, Mu-Chiou Huang, Winston Teng-Kuei Cheng and Yu-Ten Ju

    Citation: Cancer Cell International 2007 7:1

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  16. Content type: Primary research

    Mucosal squamous cell carcinoma of the head and neck is a disease of high mortality and morbidity. Interactions between the squamous cell carcinoma and the host's local immunity, and how the latter contributes...

    Authors: Sydney Ch'ng, Michael Sullivan, Lan Yuan, Paul Davis and Swee T Tan

    Citation: Cancer Cell International 2006 6:28

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  17. Content type: Hypothesis

    It is widely assumed that genotoxin-induced damage (e.g., G-to-T transversions) to the tumor suppressor gene, p53, is a direct cause of cancer. However, genotoxins also induce the stress response, which upregulat...

    Authors: Barbara Wright, Jacqueline Reimers, Karen Schmidt, Evan Burkala, Nick Davis and Ping Wei

    Citation: Cancer Cell International 2006 6:27

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  18. Content type: Primary research

    Uveal melanoma (UM) is the most common primary intraocular malignant tumor in adults, and nearly 40% of UM will develop metastasis that will ultimately lead to death. The Epithelial Cell Adhesion Molecule (EpC...

    Authors: Danilo N Odashiro, Alexandre N Odashiro, Patrícia R Pereira, Katyanne Godeiro, Emilia Antecka, Sebastian Di Cesare and Miguel N Burnier Jr

    Citation: Cancer Cell International 2006 6:26

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  19. Content type: Hypothesis

    We describe the basic tenets of the current concepts of cancer biology, and review the recent advances on the suppressor role of senescence in tumor growth and the breakdown of this barrier during the origin o...

    Authors: Rengaswami Rajaraman, Duane L Guernsey, Murali M Rajaraman and Selva R Rajaraman

    Citation: Cancer Cell International 2006 6:25

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  20. Content type: Primary research

    Reports showing susceptibility of multidrug resistant (MDR) cancer cells to immune effectors, together with P-glycoprotein (P-gp) expression in immune effector subsets, including immature natural killer (NK) c...

    Authors: Burhan Savas, Pauline E Kerr and Hugh F Pross

    Citation: Cancer Cell International 2006 6:24

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  21. Content type: Primary research

    The blood plasma and other intertissue fluids usually contain a certain amount of DNA, getting there due to a natural cell death in the organism. Cells of this organism can capture the extracellular DNA, where...

    Authors: Vladimir A Rogachev, Anastasia Likhacheva, Oksana Vratskikh, Lyudmila V Mechetina, Tamara E Sebeleva, Sergei S Bogachev, Leonid A Yakubov and Mikhail A Shurdov

    Citation: Cancer Cell International 2006 6:23

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  22. Content type: Primary research

    Despite significant achievements in the treatment of cervical cancer, it is still a deadly disease; hence newer therapeutical modalities are needed. Preliminary investigations suggest that platelet-derived gro...

    Authors: Lucia Taja-Chayeb, Alma Chavez-Blanco, Jorge Martínez-Tlahuel, Aurora González-Fierro, Myrna Candelaria, Jose Chanona-Vilchis, Elizabeth Robles and Alfonso Dueñas-Gonzalez

    Citation: Cancer Cell International 2006 6:22

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  23. Content type: Primary research

    p27(Kip1) is a cyclin-dependent kinase inhibitor. When up-regulated, p27 inhibits G1-to-S phase transition of the cell cycle. This report addresses the question of whether various nutritional and chemopreventi...

    Authors: Isao Eto

    Citation: Cancer Cell International 2006 6:20

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  24. Content type: Primary research

    Human papillomavirus type 16 (HPV-16) E5 protein co-operates with epidermal growth factor to stimulate mitogenesis of murine fibroblasts. Currently, little is known about which viral amino acids are involved i...

    Authors: Rahul Nath, Christine A Mant, Barbara Kell, John Cason and Jon M Bible

    Citation: Cancer Cell International 2006 6:19

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  25. Content type: Primary research

    Hepatitis C (HCV) viral infection is a serious medical problem in Egypt and it has a devastating impact on the Egyptian economy. It is estimated that over 15% of Egyptians are infected by the virus and thus fi...

    Authors: Mostafa K El Awady, Noha G Badr El Din, Wael T El Garf, Samar S Youssef, Moataza H Omran, Jasmin El Abd and Said A Goueli

    Citation: Cancer Cell International 2006 6:18

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  26. Content type: Review

    Cationic (positively charged) liposomes have been tested in various gene therapy clinical trials for neoplastic and other diseases. They have demonstrated selectivity for tumour vascular endothelial cells rais...

    Authors: Crispin R Dass and Peter FM Choong

    Citation: Cancer Cell International 2006 6:17

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  27. Content type: Primary research

    Urokinase-type Plasminogen Activator (uPA), a serine protease, plays a pivotal role in human breast cancer metastasis by mediating the degradation of extracellular matrix proteins and promoting cell motility. ...

    Authors: Britny J Candia, William C Hines, Christopher M Heaphy, Jeffrey K Griffith and Robert A Orlando

    Citation: Cancer Cell International 2006 6:16

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  28. Content type: Primary research

    Immortalization is a key step in malignant transformation, but immortalization alone is insufficient for transformation. Human mammary epithelial cell (HMEC) transformation is a complex process that requires a...

    Authors: Krishna Rao, Özge Alper, Kent E Opheim, George Bonnet, Kristine Wolfe, Eileen Bryant, Siobhan O'Hara Larivee, Peggy Porter and James K McDougall

    Citation: Cancer Cell International 2006 6:15

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  29. Content type: Primary research

    Human papillomavirus has been implicated in virtually all cervical cancers and is believed to be the primary etiological factor that transforms cervical epithelia. The presence of HPV in oral cancers suggests ...

    Authors: Karl Kingsley, Devin Johnson and Susan O'Malley

    Citation: Cancer Cell International 2006 6:14

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  30. Content type: Primary research

    Integrin-linked kinase (ILK) is a ubiquitously expressed protein kinase that has emerged as one of the points of convergence between integrin- and growth factor-signalling pathways.

    Authors: Glenn A Driver and Robin B Veale

    Citation: Cancer Cell International 2006 6:12

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  31. Content type: Primary research

    We have demonstrated that in some human cancer cells both chronic mild heat and ionizing radiation exposures induce a transient block in S and G2 phases of the cell cycle. During this delay, cyclin B1 protein ...

    Authors: Fiorenza Ianzini, Alessandro Bertoldo, Elizabeth A Kosmacek, Stacia L Phillips and Michael A Mackey

    Citation: Cancer Cell International 2006 6:11

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  32. Content type: Primary research

    Zinc plays important roles in maintaining normal function of the prostate and in development of prostate malignancy. It has been demonstrated that prostate malignant epithelial cells contain much less cellular...

    Authors: Liping Huang, Catherine P Kirschke and Yunfan Zhang

    Citation: Cancer Cell International 2006 6:10

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  33. Content type: Primary research

    Lovastatin and other statins may reduce the development of melanomas. The effects on melanoma cells and their ability to enhance angiogenesis in a co-culture system presented an opportunity to assess whether L...

    Authors: Ivan Depasquale and Denys N Wheatley

    Citation: Cancer Cell International 2006 6:9

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  34. Content type: Primary research

    Plasminogen activators are known to play a key role in the remodeling of bone matrix which occurs during tumor progression, bone metastasis and bone growth. Dysfunctional remodeling of bone matrix gives rise t...

    Authors: Daniel Vial, Elizabeth Monaghan-Benson and Paula J McKeown-Longo

    Citation: Cancer Cell International 2006 6:8

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  35. Content type: Primary research

    Chlorogenic acid (CHL), the most potent functional inhibitor of the microsomal glucose-6-phosphate translocase (G6PT), is thought to possess cancer chemopreventive properties. It is not known, however, whether...

    Authors: Anissa Belkaid, Jean-Christophe Currie, Julie Desgagnés and Borhane Annabi

    Citation: Cancer Cell International 2006 6:7

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  36. Content type: Primary research

    In order to explore a pre-clinical method to evaluate if [18F]FDG is valid for monitoring early response, we investigated the uptake of FDG in Multicellular tumour spheroids (MTS) without and with treatment with ...

    Authors: Azita Monazzam, Pasha Razifar, Martin Simonsson, Fredrik Qvarnström, Raymond Josephsson, Carl Blomqvist, Bengt Långström and Mats Bergström

    Citation: Cancer Cell International 2006 6:6

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  37. Content type: Review

    Cancer is one of the most complex dynamic human disease. Despite rapid advances in the fields of molecular and cell biology, it is still widely debated as to how neoplastic cells progress through carcinogenesi...

    Authors: Fabio Grizzi and Maurizio Chiriva-Internati

    Citation: Cancer Cell International 2006 6:4

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  38. Content type: Primary research

    The product of the retinoblastoma-susceptibility gene (pRb) is a substrate for Protein Phosphatase 1 (PP1). At mitotic exit, all three PP1 isoforms, α, γ1 and δ, bind to pRb and dephosphorylate its Ser/Thr sit...

    Authors: Michele Vietri, Mariarita Bianchi, John W Ludlow, Sibylle Mittnacht and Emma Villa-Moruzzi

    Citation: Cancer Cell International 2006 6:3

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  39. Content type: Primary research

    Among the epigenetic alterations occurring in cancer, DNA hypermethylation and histone hypoacetylation are the focus of intense research because their pharmacological inhibition has shown to produce antineopla...

    Authors: Alma Chavez-Blanco, Carlos Perez-Plasencia, Enrique Perez-Cardenas, Claudia Carrasco-Legleu, Edgar Rangel-Lopez, Blanca Segura-Pacheco, Lucia Taja-Chayeb, Catalina Trejo-Becerril, Aurora Gonzalez-Fierro, Myrna Candelaria, Gustavo Cabrera and Alfonso Duenas-Gonzalez

    Citation: Cancer Cell International 2006 6:2

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  40. Content type: Primary research

    Pluripotent mouse embryonic stem (ES) cells can be induced in vitro to become neural progenitors. Upon transplantation, neural progenitors migrate toward areas of damage and inflammation in the CNS. We tested whe...

    Authors: Peter Serfozo, Maggie S Schlarman, Chris Pierret, Bernard L Maria and Mark D Kirk

    Citation: Cancer Cell International 2006 6:1

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  41. Content type: Primary research

    Mitochondrial DNA (mtDNA) is known for high mutation rates caused by lack of protective histones, inefficient DNA repair systems, and continuous exposure to mutagenic effects of oxygen radicals. Alterations in...

    Authors: Himani Sharma, Archna Singh, Chandresh Sharma, Sunesh Kumar Jain and Neeta Singh

    Citation: Cancer Cell International 2005 5:34

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  42. Content type: Editorial

    Clinicians will argue that cancer can only really receive the treatment that is needed through thorough understanding of medicine. However, even empirical approaches to therapy result in experimental analysis ...

    Authors: Denys N Wheatley Editor-in-Chief, Cancer Cell International

    Citation: Cancer Cell International 2005 5:33

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  43. Content type: Primary research

    Considering the width and importance of using Multicellular Tumor Spheroids (MTS) in oncology research, size determination of MTSs by an accurate and fast method is essential. In the present study an effective...

    Authors: Azita Monazzam, Pasha Razifar, Örjan Lindhe, Raymond Josephsson, Bengt Långström and Mats Bergström

    Citation: Cancer Cell International 2005 5:32

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