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  1. Content type: Primary research

    Mast cells are known to accumulate at sites of inflammation and upon activation to release their granule content, e.g. histamine, cytokines and proteases. The secretory leukocyte protease inhibitor (SLPI) is p...

    Authors: Camilla Hollander, Max Nyström, Sabina Janciauskiene and Ulla Westin

    Citation: Cancer Cell International 2003 3:14

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  2. Content type: Primary research

    The β-catenin link between membrane-bound cadherins and the actin cytoskeleton regulates cell adhesion and consequently metastasis. Abnormal stabilisation of β-catenin enhances its transcriptional activities. ...

    Authors: Lindsay JG Jones and Rob B Veale

    Citation: Cancer Cell International 2003 3:13

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  3. Content type: Primary research

    One of the major cellular serine/threonine protein phosphatases is protein phosphatase type 1 (PP1). Studies employing many eukaryotic systems all point to a crucial role for PP1 activity in controlling cell c...

    Authors: Jay E Reeder, Mark P Sowden, Edward M Messing, Peter Klover, Emma Villa-Moruzzi and John W Ludlow

    Citation: Cancer Cell International 2003 3:12

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  4. Content type: Primary research

    Malignant rhabdoid tumors (MRTs) are extremely aggressive and resist current radio- and chemotherapic treatments. To gain insight into the dysfunctions of MRT cells, the apoptotic response of a model cell line...

    Authors: Silvano Nocentini

    Citation: Cancer Cell International 2003 3:11

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  5. Content type: Primary research

    Human MCF-7 cells have been studied extensively as a model for breast cancer cell growth. Many reports have established that serum-starved MCF-7 cells can be induced to proliferate upon the sole addition of 17...

    Authors: Irene HL Hamelers, Richard FMA van Schaik, John S Sussenbach and Paul H Steenbergh

    Citation: Cancer Cell International 2003 3:10

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  6. Content type: Primary research

    Telomerase is a ribonucleoprotein that synthesizes telomeres and plays an important role in chromosomal stability and cellular immortalisation. Telomerase activity is detectable in most human cancers but not i...

    Authors: Abd E Elkak, Robert F Newbold, Valene Thomas and Kefah Mokbel

    Citation: Cancer Cell International 2003 3:9

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  7. Content type: Primary research

    An important physiological function of the normal prostate gland is the synthesis and secretion of a citrate rich prostatic fluid. In prostate cancer, citrate production levels are reduced as a result of alter...

    Authors: Ali Mobasheri, Richard Fox, Iain Evans, Fay Cullingham, Pablo Martín-Vasallo and Christopher S Foster

    Citation: Cancer Cell International 2003 3:8

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  8. Content type: Primary research

    The molecular mechanisms by which iron is physiologically transported trough the cellular membranes are still only partially understood. Several studies indicate that a reduction step of ferric iron to ferrous...

    Authors: Silvia Dominici, Lisa Pieri, Mario Comporti and Alfonso Pompella

    Citation: Cancer Cell International 2003 3:7

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  9. Content type: Primary research

    Changes of membrane lipids in cisplatin-sensitive A549 and cisplatin-resistant A549/DDP cells during the apoptotic process induced by a clinical dose of cisplatin (30 μM) were detected by 1H and 31P-NMR spectrosc...

    Authors: Zhenhua Huang, Yufeng Tong, Jinfeng Wang and Youguo Huang

    Citation: Cancer Cell International 2003 3:5

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  10. Content type: Primary research

    The expression of major histocompatibility complex class II (MHCII) antigens in both mouse and human tumors is rare, and these antigens are not easily inducible by IFN-gamma (IFNg). Since MHCII may play an imp...

    Authors: Yuri Kudinov, Charles L Wiseman and Alexander I Kharazi

    Citation: Cancer Cell International 2003 3:4

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  11. Content type: Primary research

    d-α-tocopherol is a naturally occurring form of vitamin E not previously known to have antitumor activity. Synthetic vitamin E (sE) is a commonly used dietary supplement consisting of a mixture of d-α-tocopher...

    Authors: Ivan L Cameron, Jesus Munoz, Christopher J Barnes and W Elaine Hardman

    Citation: Cancer Cell International 2003 3:3

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  12. Content type: Primary research

    Eukaryotic initiation factor 4E (eIF4E) is essential for cap-dependent initiation of translation. Cell proliferation is associated with increased activity of eIF4E and elevated expression of eIF4E leads to tum...

    Authors: Hong Jiang, Jennifer Coleman, Robin Miskimins and W Keith Miskimins

    Citation: Cancer Cell International 2003 3:2

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  13. Content type: Primary research

    Since lung epithelial cells are constantly being exposed to reactive oxygen intermediates (ROIs), the alveolar surface is a major site of oxidative stress, and each cell type may respond differently to oxidati...

    Authors: Yoshihiro Fujii, Katsuyuki Tomita, Hiroyuki Sano, Akira Yamasaki, Yutaka Hitsuda, Ian M Adcock and Eiji Shimizu

    Citation: Cancer Cell International 2002 2:16

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  14. Content type: Primary research

    The effects of the vitamin A metabolite retinoic acid (RA) are mediated at the transcriptional level by retinoic acid receptors (RAR). These proteins are part of a superfamily of transcription factors which ac...

    Authors: David L Crowe and Randie Kim

    Citation: Cancer Cell International 2002 2:15

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  15. Content type: Primary research

    We previously reported the usefulness of the αGal epitope as a target molecule for gene therapy against cancer. To induce cancer cell specific transcription of the αGal epitope, an expression vector which synt...

    Authors: Tokihiko Sawada, Osamu Yamada, Naoko Yoshimura, Keiko Hatori, Shohei Fuchinoue and Satoshi Teraoka

    Citation: Cancer Cell International 2002 2:14

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  16. Content type: Hypothesis

    A kinetic model has been developed to study cancer growth. Cancer growth has been considered as interaction between various independent but interacting compartments. The model considers cell growth and metasta...

    Authors: Siddhartha Jain

    Citation: Cancer Cell International 2002 2:13

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  17. Content type: Primary research

    The C1D gene is expressed in a broad spectrum of mammalian cells and tissues but its product induces apoptotic cell death when exceeding a critical level. Critical levels are achieved in a fraction of cells by...

    Authors: Karsten Rothbarth, Hermann Stammer and Dieter Werner

    Citation: Cancer Cell International 2002 2:12

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  18. Content type: Primary research

    It is postulated that the unusual manifestations of Kaposis's sarcoma cells in nonendothelial brain tissues and on eyeballs in advanced acquired immune deficiency syndrome (AIDS) cases are metastasized AIDS-Ka...

    Authors: Mahruf U Rahman and Amitabha Mazumder

    Citation: Cancer Cell International 2002 2:11

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  19. Content type: Primary research

    Supplementing mice with high levels of dietary n-3 polyunsaturated fatty acids (PUFAs) increases the n-3 PUFAs in cell membranes, increases the susceptibility of the cells for lipid peroxidation (LPO) and decr...

    Authors: W Elaine Hardman, Jesus Munoz Jr and Ivan L Cameron

    Citation: Cancer Cell International 2002 2:10

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  20. Content type: Primary research

    Isopeptides (ε-peptides) of lysine, with a given Mw and low polydispersity (10–400 units), were synthesized to study the relationship between their chemical structure and biological effect. The designed compou...

    Authors: B Szende, Gy Szökán, E Tyihá, K Pál, R Gáborjányi, M Almás and A R Khlafulla

    Citation: Cancer Cell International 2002 2:4

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  21. Content type: Primary research

    The issue remains unresolved as to whether low frequency magnetic fields can affect cell behaviour, with the possibility that they may be in part responsible for the increased incidence of leukaemia in parts o...

    Authors: Paul A Harris, Justin Lamb, Brian Heaton and Denys N Wheatley

    Citation: Cancer Cell International 2002 2:3

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  22. Content type: Primary research

    The p16INK4A gene product halts cell proliferation by preventing phosphorylation of the Rb protein. The p16INK4a gene is often deleted in human glioblastoma multiforme, contributing to unchecked Rb phosphorylatio...

    Authors: Bryan E Strauss, Ricardo BV Fontes, Claudimara FP Lotfi, Ana Lucia Skorupa, Ione Bartol, José Cipolla-Neto and Eugenia Costanzi-Strauss

    Citation: Cancer Cell International 2002 2:2

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  23. Content type: Primary research

    We describe an alternative method to determine mRNA half-life (t1/2) based on the Real-Time RT-PCR procedure. This approach was evaluated by using the β-actin gene as a reference molecule for measuring of mRNA st...

    Authors: Guy J Leclerc, Gilles M Leclerc and Julio C Barredo

    Citation: Cancer Cell International 2002 2:1

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  24. Content type: Primary research

    5-AzaCytidine (AzaC) is a DNA demethylating drugs that has been shown to inhibit cell growth and to induce apoptosis in certain cancer cells. Induced expression of the galectin1 (Gal1) protein, a galactoside-b...

    Authors: Florence Poirier, Philippe Bourin, Dominique Bladier, Raymonde Joubert-Caron and Michel Caron

    Citation: Cancer Cell International 2001 1:2

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  25. Content type: Review

    Mitotic death is a delayed response of p53 mutant tumours that are resistant to genotoxic damage. Questions surround why this response is so delayed and how its mechanisms serve a survival function. After unco...

    Authors: Jekaterina Erenpreisa and M S Cragg

    Citation: Cancer Cell International 2001 1:1

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