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  1. Content type: Primary research

    Malignant glioma cells are particularly motile and can travel diffusely through the brain parenchyma, apparently without following anatomical structures to guide their migration. The neural adhesion/recognitio...

    Authors: Muhua Yang, Shalini Adla, Murali K Temburni, Vivek P Patel, Errin L Lagow, Owen A Brady, Jing Tian, Magdy I Boulos and Deni S Galileo

    Citation: Cancer Cell International 2009 9:27

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  2. Content type: Review

    Osteoprotegerin (OPG), a member of the tumor necrosis factor (TNF) receptor superfamily, contributes determinatively to the bone remodeling as well as to the pathogenetic mechanism of bone malignancies and dis...

    Authors: Sofia Fili, Maria Karalaki and Bernhard Schaller

    Citation: Cancer Cell International 2009 9:26

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  3. Content type: Primary research

    Glucosamine is known as a toxic agent for several malignant cell lines and transplanted tumors with little toxicity to normal host tissues. However, the mechanisms underlying anticancer activity of glucosamine...

    Authors: Viktor Chesnokov, Chao Sun and Keiichi Itakura

    Citation: Cancer Cell International 2009 9:25

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  4. Content type: Primary research

    The Signal Transducer and Activator of Transcription (STAT) proteins comprise a family of latent transcription factors with diverse functions. STAT3 has well established roles in cell proliferation, growth and...

    Authors: Brian Hutzen, William Willis, Sarah Jones, Ling Cen, Stephanie Deangelis, Beng Fuh and Jiayuh Lin

    Citation: Cancer Cell International 2009 9:24

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  5. Content type: Primary research

    Ca2+ is known to be involved in a number of metastatic processes including motility and proliferation which can result in store-depletion of Ca2+. Up regulation of genes which contribute to store operated channel...

    Authors: Ebru Aydar, Syn Yeo, Mustafa Djamgoz and Christopher Palmer

    Citation: Cancer Cell International 2009 9:23

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  6. Content type: Primary research

    Gap junction intercellular communication (GJIC) is considered to play a role in the regulation of homeostasis because it regulates important processes, such as cell proliferation and cell differentiation. A re...

    Authors: Marisa Ionta, Raphael Adolpho Sant'ana Ferreira, Sandra Cristina Pfister and Gláucia Maria Machado-Santelli

    Citation: Cancer Cell International 2009 9:22

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  7. Content type: Primary research

    The human immunodeficiency virus type 1 (HIV-1) accessory protein Vpr induces apoptosis after cell cycle arrest at the G2 phase in primate cells. We have reported previously that C81, a carboxy-terminally truncat...

    Authors: Mizuho Nonaka, Yoshie Hashimoto, Shin-nosuke Takeshima and Yoko Aida

    Citation: Cancer Cell International 2009 9:20

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  8. Content type: Primary research

    NUCKS (Nuclear, Casein Kinase and Cyclin-dependent Kinase Substrate) is a nuclear, DNA-binding and highly phosphorylated protein. A number of reports show that NUCKS is highly expressed on the level of mRNA in se...

    Authors: Yiannis Drosos, Mirsini Kouloukoussa, Anne Carine Østvold, Kirsten Grundt, Nikos Goutas, Dimitrios Vlachodimitropoulos, Sophia Havaki, Panagoula Kollia, Christos Kittas, Evangelos Marinos and Vassiliki Aleporou-Marinou

    Citation: Cancer Cell International 2009 9:19

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  9. Content type: Primary research

    SATB1 is a nuclear protein that has been recently reported to be a 'genome organizer' which delineates specific epigenetic modifications at target gene loci, directly up-regulating metastasis-associated genes ...

    Authors: Neill Patani, Wen Jiang, Robert Mansel, Robert Newbold and Kefah Mokbel

    Citation: Cancer Cell International 2009 9:18

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  10. Content type: Primary research

    CD26 is a type II, cell surface glycoprotein known as dipeptidyl peptidase (DPP) IV. Previous studies have revealed CD26 expression in T cell leukemia/lymphoma and malignant mesothelioma, and an inhibitory eff...

    Authors: Kohji Yamada, Mutsumi Hayashi, Wenlin Du, Kei Ohnuma, Michiie Sakamoto, Chikao Morimoto and Taketo Yamada

    Citation: Cancer Cell International 2009 9:17

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  11. Content type: Primary research

    Eurycomanone is a cytotoxic compound found in Eurycoma longifolia Jack. Previous studies had noted the cytotoxic effect against various cancer cell lines. The aim of this study is to investigate the cytotoxici...

    Authors: Yusmazura Zakaria, Asmah Rahmat, Azimahtol Hawariah Lope Pihie, Noor Rain Abdullah and Peter J Houghton

    Citation: Cancer Cell International 2009 9:16

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  12. Content type: Primary research

    Cancer and Alzheimer's disease (AD) are two seemingly distinct diseases and rarely occur simultaneously in patients. To explore molecular determinants differentiating pathogenic routes towards AD or cancer, we...

    Authors: Hong Zhao, Jinmin Zhu, Kemi Cui, Xiaoyin Xu, Megan O'Brien, Kelvin K Wong, Santosh Kesari, Weiming Xia and Stephen TC Wong

    Citation: Cancer Cell International 2009 9:15

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  13. Content type: Primary research

    Recent evidence suggests that several human cancers are capable of uncoupling of mitochondrial ATP generation in the presence of intact tricarboxylic acid (TCA) enzymes. The goal of the current study was to te...

    Authors: Eugene J Fine, Anna Miller, Edward V Quadros, Jeffrey M Sequeira and Richard D Feinman

    Citation: Cancer Cell International 2009 9:14

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  14. Content type: Primary research

    Metabolic states of neoplastic cells are increasingly being relied upon for diagnostic and prognostic assessment of neoplastic conditions. The nucleic acid distribution pattern of cells in general, in terms of...

    Authors: Godwin N Isitor, Mervyn Campbell and Shivananda B Nayak

    Citation: Cancer Cell International 2009 9:13

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  15. Content type: Primary research

    In the Western world, endometrial cancers are the most common gynaecological neoplastic disorders among women. Initial symptoms are often vague and may be confused with several other conditions or disorders. T...

    Authors: Sandra Karlsson, Björn Olsson and Karin Klinga-Levan

    Citation: Cancer Cell International 2009 9:12

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  16. Content type: Primary research

    The Wnt family of secreted proteins is implicated in the regulation of cell fate during development, as well as in cell proliferation, morphology, and migration. Aberrant activation of the Wnt/β-catenin signal...

    Authors: Kelly J Gauger, Jeremy M Hugh, Melissa A Troester and Sallie Smith Schneider

    Citation: Cancer Cell International 2009 9:11

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  17. Content type: Primary research

    DNA methylation is an epigenetic phenomenon known to play an important role in the development of cancers, including colorectal cancer (CRC). Aberrant methylation of promoter regions of genes is potentially re...

    Authors: Sylwia Flis, Agnieszka Gnyszka, Irena Misiewicz-Krzemińska and Jacek Spławiński

    Citation: Cancer Cell International 2009 9:10

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  18. Content type: Primary research

    Protein used in medicine, e.g. interferon, are immunogenic and quickly broken down by the body. Pegylation is a recognized way of preserving their integrity and reducing immune reactions, and works well with e...

    Authors: Sam-Mui Tsui, Wai-Man Lam, Tin-Lun Lam, Hiu-Chi Chong, Pui-Kin So, Sui-Yi Kwok, Simon Arnold, Paul Ning-Man Cheng, Denys N Wheatley, Wai-Hung Lo and Yun-Chung Leung

    Citation: Cancer Cell International 2009 9:9

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  19. Content type: Primary research

    MCF-10A cells are near diploid and normal human mammary epithelial cells. In three-dimensional reconstituted basement membrane culture, they undergo a well-defined program of proliferation, differentiation, an...

    Authors: Karen M Imbalzano, Iva Tatarkova, Anthony N Imbalzano and Jeffrey A Nickerson

    Citation: Cancer Cell International 2009 9:7

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  20. Content type: Primary research

    Piper sarmentosum, locally known as kaduk is belonging to the family of Piperaceae. It is our interest to evaluate their effect on human hepatoma cell line (HepG2) for the potential of anticarcinogenic activity.

    Authors: Shahrul Hisham Zainal Ariffin, Wan Haifa Haryani Wan Omar, Zaidah Zainal Ariffin, Muhd Fauzi Safian, Sahidan Senafi and Rohaya Megat Abdul Wahab

    Citation: Cancer Cell International 2009 9:6

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  21. Content type: Primary research

    The prototypical antiprogestin mifepristone exhibits potent growth inhibition activity towards ovarian cancer cells in vitro and in vivo. The aim of this research was to establish whether mifepristone is capable ...

    Authors: Elizabeth M Freeburg, Alicia A Goyeneche, Erin E Seidel and Carlos M Telleria

    Citation: Cancer Cell International 2009 9:4

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  22. Content type: Primary research

    Resistance of cholangiocarcinoma to chemotherapy is a major problem in cancer treatment. The mechanism of resistance is believed to involve phosphoinositide-3- kinase (PI3K)/Akt activation. Although the platin...

    Authors: Kawin Leelawat, Siriluck Narong, Wandee Udomchaiprasertkul, Surang Leelawat and Sumalee Tungpradubkul

    Citation: Cancer Cell International 2009 9:3

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  23. Content type: Primary research

    Breast cancer is a major malignancy affecting females worldwide. It is the most common cause of death from cancer in women. Cell lines are widely used in laboratory research and particularly as in vitro models in...

    Authors: Chao Shen, Meijia Gu, Dan Liang, Lixia Miao, Liu Hu, Congyi Zheng and Jiakuan Chen

    Citation: Cancer Cell International 2009 9:2

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  24. Content type: Primary research

    It has been suggested that combined effect of natural products may improve the treatment effectiveness in combating proliferation of cancer cells. The present study was undertaken to evaluate the possibility t...

    Authors: Yew Hoong Cheah, Fariza Juliana Nordin, Rozie Sarip, Thiam Tsui Tee, Hawariah Lope Pihie Azimahtol, Hasnah M Sirat, Badrul Amini Abd Rashid, Noor Rain Abdullah and Zakiah Ismail

    Citation: Cancer Cell International 2009 9:1

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  25. Content type: Hypothesis

    Cancer expansion depends on host organ conditions that permit growth. Since such microenvironmental nourishment is limited we argue here that an autologous, therapeutically engineered and faster metabolizing cell...

    Authors: Thomas S Deisboeck and Zhihui Wang

    Citation: Cancer Cell International 2008 8:19

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  26. Content type: Primary research

    ErbB3-binding protein 1 (Ebp1) is a member of the PA2G4 family of proliferation-regulated proteins that is expressed in multiple malignant and non-malignant cells. ErbB3 and other members of the EGFR family have ...

    Authors: Philippe O Gannon, Ismaël Hervé Koumakpayi, Cécile Le Page, Pierre I Karakiewicz, Anne-Marie Mes-Masson and Fred Saad

    Citation: Cancer Cell International 2008 8:18

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  27. Content type: Primary research

    The aim of this work was to confirm the existence of volatile organic compounds (VOCs) specifically released or consumed by lung cancer cells.

    Authors: Wojciech Filipiak, Andreas Sponring, Tomas Mikoviny, Clemens Ager, Jochen Schubert, Wolfram Miekisch, Anton Amann and Jakob Troppmair

    Citation: Cancer Cell International 2008 8:17

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  28. Content type: Primary research

    Most patients with advanced Ewing's sarcoma (EWS) respond poorly to conventional chemotherapy, indicating the need for new treatment approaches. Epigenetic events, such as promoter hypermethylation and chromat...

    Authors: Annie Hurtubise, Mark L Bernstein and Richard L Momparler

    Citation: Cancer Cell International 2008 8:16

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  29. Content type: Primary research

    Alterations in the processing of the genetic information in carcinogenesis result from stable genetic mutations or epigenetic modifications. It is becoming clear that nucleosomal histones are central to proper...

    Authors: Hideo Watanabe, Kenzo Soejima, Hiroyuki Yasuda, Ichiro Kawada, Ichiro Nakachi, Satoshi Yoda, Katsuhiko Naoki and Akitoshi Ishizaka

    Citation: Cancer Cell International 2008 8:15

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  30. Content type: Review

    Human herpesvirus (HHV)-8 associated oncogenesis, a state of immune impairment, a local inflammatory environment, angiogenesis and HIV infection occurring concurrently are important factors for the development...

    Authors: Neil H Wood and Liviu Feller

    Citation: Cancer Cell International 2008 8:14

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  31. Content type: Primary research

    Aberrations in DNA methylation patterns promote changes in gene expression patterns and are invariably associated with neoplasia. DNA methylation is carried out and maintained by several DNA methyltransferases...

    Authors: Ahmed Yaqinuddin, Sohail A Qureshi, Romena Qazi and Farhat Abbas

    Citation: Cancer Cell International 2008 8:13

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  32. Content type: Primary research

    Breast cancer is the most common cancer and cause of deaths in women around the world. Oncogene amplification usually occurs late in tumor progression and correlates well with aggressiveness of tumor. In fact ...

    Authors: Nawfal I Ismail, Gurjeet Kaur, Hasnah Hashim and Mohammed S Hassan

    Citation: Cancer Cell International 2008 8:12

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  33. Content type: Primary research

    A localized hypoxic environment occurs during tumor growth necessitating an angiogenic response or tumor necrosis results. Novel cancer treatment strategies take advantage of tumor-induced vascularisation by c...

    Authors: Jamie M Heinzman, Stacey L Brower and Jason E Bush

    Citation: Cancer Cell International 2008 8:11

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  34. Content type: Hypothesis

    Brain tumors are now the leading cause of cancer-related deaths in children under age 15. Malignant gliomas are, for all practical purposes, incurable and new therapeutic approaches are desperately needed. One...

    Authors: Shengwen Calvin Li and William Gunter Loudon

    Citation: Cancer Cell International 2008 8:9

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  35. Content type: Primary research

    4-Hydroxycoumarin (4-HC) is a coumarin that lacks anticoagulant activity. 4-HC affects the cytoskeletal stability and decreases cell adhesion and motility of the melanoma cell line B16-F10. Together with integ...

    Authors: Marco A Velasco-Velázquez, Nohemí Salinas-Jazmín, Nicandro Mendoza-Patiño and Juan J Mandoki

    Citation: Cancer Cell International 2008 8:8

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  36. Content type: Primary research

    Breast cancer is the most common cause of cancer death in the western world. The expression differences of many proteins are associated with breast cancer progression or suppression. The purpose of the study w...

    Authors: Nawfal I Ismail, Gurjeet Kaur, Hasnah Hashim and Mohammed S Hassan

    Citation: Cancer Cell International 2008 8:6

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  37. Content type: Primary research

    c-kit is expressed in various cell types during development and it has been linked to the promotion of cellular migration, proliferation and/or survival of melanoblasts, hematopoietic progenitors and primordial g...

    Authors: Maricel V Maffini, Ana M Soto, Carlos Sonnenschein, Nikoletta Papadopoulos and Theoharis C Theoharides

    Citation: Cancer Cell International 2008 8:5

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  38. Content type: Primary research

    Truncated variants of Ku86 protein have previously been detected in 86% to 100% of freshly isolated patient multiple myeloma (MM) cells. Since, the Ku70/Ku86 heterodimer functions as the regulatory subunit of ...

    Authors: Charles A Gullo, Feng Ge, Geraline Cow and Gerrard Teoh

    Citation: Cancer Cell International 2008 8:4

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  39. Content type: Primary research

    Prostate cancer is a leading cause of male cancer specific mortality. When cure by radical prostatectomy is not possible the next line of prostate cancer treatment is androgen deprivation. However prolonged an...

    Authors: Greg Shaw and David M Prowse

    Citation: Cancer Cell International 2008 8:3

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  40. Content type: Primary research

    Tyrosine kinase inhibitors (TKIs) have gained much attention in recent years as targeted agents for the treatment of a wide range of human cancers. We have investigated the effect of the TKIs gefitinib and van...

    Authors: Mattias K Andersson and Pierre Åman

    Citation: Cancer Cell International 2008 8:1

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  41. Content type: Primary research

    Glucocorticoids (GC's) play an integral role in treatment strategies designed to combat various forms of hematological malignancies. GCs also are powerful inhibitors of the immune system, through regulation of...

    Authors: Aaron L Miller, Spogmai Komak, M Scott Webb, Edward H Leiter and E Brad Thompson

    Citation: Cancer Cell International 2007 7:18

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  42. Content type: Primary research

    The CXCR4/CXCL12 chemokine axis may play a critical role in guiding CXCR4+ circulating malignant cells to organ specific locations that actively secrete its ligand CXCL12 (SDF-1) such as bone, brain, liver, an...

    Authors: Sebastian Di Cesare, Jean-Claude Marshall, Bruno F Fernandes, Patrick Logan, Emilia Antecka, Vasco Bravo Filho and Miguel N Burnier Jr

    Citation: Cancer Cell International 2007 7:17

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  43. Content type: Primary research

    Integrins are transmembrane adhesion receptors that provide the physical link between the actin cytoskeleton and the extracellular matrix. It has been well established that integrins play a major role in vario...

    Authors: Sophia Havaki, Mirsini Kouloukoussa, Kawther Amawi, Yiannis Drosos, Leonidas D Arvanitis, Nikos Goutas, Dimitrios Vlachodimitropoulos, Stamatis D Vassilaros, Eleni Z Katsantoni, Irene Voloudakis-Baltatzis, Vassiliki Aleporou-Marinou, Christos Kittas and Evangelos Marinos

    Citation: Cancer Cell International 2007 7:16

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