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Page 24 of 33

  1. Our recent evidence showed that Toll like receptor 9 (TLR9) signaling could enhance the growth and metastatic potential of human lung cancer cells through repressing microRNA-7 (miR-7) expression. Human antige...

    Authors: Yong-Ju Li, Chun-Hong Wang, Ya Zhou, Zheng-Yuan Liao, Shun-Fei Zhu, Yan Hu, Chao Chen, Jun-Min Luo, Zhen-Ke Wen and Lin Xu

    Citation: Cancer Cell International 2013 13:90

    Content type: Primary research

    Published on:

  2. Acidic extracellular pH is a major feature of tumor tissue, extracellular acidification being primarily considered to be due to lactate secretion from anaerobic glycolysis. Clinicopathological evidence shows t...

    Authors: Yasumasa Kato, Shigeyuki Ozawa, Chihiro Miyamoto, Yojiro Maehata, Atsuko Suzuki, Toyonobu Maeda and Yuh Baba

    Citation: Cancer Cell International 2013 13:89

    Content type: Review

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  3. The multiple tyrosine kinase inhibitors SU6668 have a promising therapeutic effect on the progression of hematological malignancies and some solid tumors. Here, we determined its effect on triple negative brea...

    Authors: Lu Wang, Zhaozhe Liu, Dongchu Ma, Ying Piao, Fang Guo, Yaling Han and Xiaodong Xie

    Citation: Cancer Cell International 2013 13:88

    Content type: Primary research

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  4. 2-Methoxyestradiol has been shown to induce both autophagy and apoptosis in various carcinogenic cell lines. Although a promising anti-cancer agent, it has poor bioavailability and rapid in vivo metabolism which ...

    Authors: Anne E Theron, Elsie M Nolte, Laurence Lafanechère and Annie M Joubert

    Citation: Cancer Cell International 2013 13:87

    Content type: Primary research

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  5. Despite advances in detection and therapy, epithelial ovarian cancer (EOC) still represents the most lethal gynecologic malignancy in women worldwide. The high mortality of EOC is mainly due to late-stage diag...

    Authors: Ying Chen, Lei Zhang and Quan Hao

    Citation: Cancer Cell International 2013 13:86

    Content type: Review

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  6. Glioblastoma stem-like cells (GSC) have been shown to promote tumor growth, tumor-associated neovascularization, therapeutic resistance, and metastasis. CXCR4 receptors have been found involved in the prolifer...

    Authors: Chin-Cheng Lee, Jin-Huei Lai, Dueng-Yang Hueng, Hsin-I Ma, Yuan- Chiang Chung, Ya-yun Sun, Yih-Ju Tsai, Wen-Ben Wu and Chih-Li Chen

    Citation: Cancer Cell International 2013 13:85

    Content type: Primary research

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  7. The prognosis of oral squamous cell carcinoma is very poor due to local recurrence and metastasis. This study explores the molecular events involved in oral carcinoma with the goal of developing novel therapeu...

    Authors: Bin Zhang, Ke Yi Li, Hai Ying Chen, Shao Dong Pan, Li Cheng Jiang, Ya Ping Wu and Shu Wei Liu

    Citation: Cancer Cell International 2013 13:83

    Content type: Primary research

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  8. It has been shown that proteasome inhibition leads to growth arrest in the G1 phase of the cell cycle and/or induction of apoptosis. However, it was found that some of these inhibitors do not induce apoptosis ...

    Authors: Khaled Y Orabi, Mohamed S Abaza, Khalid A El Sayed, Ahmed Y Elnagar, Rajaa Al-Attiyah and Radhika P Guleri

    Citation: Cancer Cell International 2013 13:82

    Content type: Primary research

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  9. B7-H3 and matrix metalloproteinases 2 (MMP-2) are reported highly expressed in malignant tumor, we investigate the relationship between B7-H3 expression and MMP-2 on malignant behavior and prognosis predictabl...

    Authors: Lihua Xu, Xiangmin Ding, Huo Tan and Jianjun Qian

    Citation: Cancer Cell International 2013 13:81

    Content type: Primary research

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  10. Citation: Cancer Cell International 2013 13:80

    Content type: Erratum

    Published on:

    The original article was published in Cancer Cell International 2012 12:2

  11. The human “Elston and Ellis grading method” was utilized in dogs with mammary tumor to examine its relation to prognosis in this species, based on a 2-year follow-up period. Although cytopathology is widely us...

    Authors: Radmehr Shafiee, Javad Javanbakht, Nahid Atyabi, Pegah Kheradmand, Danial Kheradmand, Alimohammad Bahrami, Hasti Daraei and Farshid Khadivar

    Citation: Cancer Cell International 2013 13:469

    Content type: Primary research

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    The Retraction Note to this article has been published in Cancer Cell International 2016 16:83

  12. Recent evidence suggests a subset of cells within a tumor with "stem-like" characteristics. These cells are able to transplant tumors in immunodeficient hosts. Distinct from non-malignant stem cells, cancer st...

    Authors: Rüdiger M Zimmerer, Philippe Korn, Philippe Demougin, Andreas Kampmann, Horst Kokemüller, André M Eckardt, Nils-Claudius Gellrich and Frank Tavassol

    Citation: Cancer Cell International 2013 13:78

    Content type: Primary research

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  13. Taxol is a powerful chemotherapy agent leading to mitotic arrest and cell death; however, its clinical efficacy has been hampered due to the development of drug resistance. Taxol specifically targets the cell ...

    Authors: Xueqing Wang, Lingya Pan, Ning Mao, Lifang Sun, Xiangjuan Qin and Jie Yin

    Citation: Cancer Cell International 2013 13:77

    Content type: Primary research

    Published on:

  14. Epithelial-mesenchymal transition (EMT) is a process implicated in cancer metastasis that involves the conversion of epithelial cells to a more mesenchymal and invasive cell phenotype. In breast cancer cells E...

    Authors: Felicity M Davis, Michelle T Parsonage, Peter J Cabot, Marie-Odile Parat, Erik W Thompson, Sarah J Roberts-Thomson and Gregory R Monteith

    Citation: Cancer Cell International 2013 13:76

    Content type: Primary research

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  15. One of the most popular and versatile model of murine melanoma is by inoculating B16 cells in the syngeneic C57BL6J mouse strain. A characterization of different B16 modified cell sub-lines will be of real pra...

    Authors: Corina Danciu, Alexandra Falamas, Cristina Dehelean, Codruta Soica, Heinfried Radeke, Lucian Barbu-Tudoran, Florina Bojin, Simona Cîntă Pînzaru and Melania F Munteanu

    Citation: Cancer Cell International 2013 13:75

    Content type: Primary research

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  16. Transforming growth factor beta (TGFβ) is transiently increased in the mammary gland during involution and by radiation. While TGFβ normally has a tumour suppressor role, prolonged exposure to TGFβ can induce ...

    Authors: Karen A Dunphy, Jae-Hong Seo, Daniel J Kim, Amy L Roberts, Luwei Tao, James DiRenzo, Amanda L Balboni, Giovanna M Crisi, Mary J Hagen, Thiruppavai Chandrasekaran, Kelly J Gauger, Sallie Smith Schneider and D Joseph Jerry

    Citation: Cancer Cell International 2013 13:74

    Content type: Primary research

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  17. Volatile organic compounds (VOCs) emitted by human body offer a unique insight into biochemical processes ongoing in healthy and diseased human organisms. Unfortunately, in many cases their origin and metaboli...

    Authors: Paweł Mochalski, Andreas Sponring, Julian King, Karl Unterkofler, Jakob Troppmair and Anton Amann

    Citation: Cancer Cell International 2013 13:72

    Content type: Primary research

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  18. Emodin is a natural anthraquinone derivative isolated from the Rheum palmatum L. Aim: The aim of the present study was to investigate the effect of emodin on the apoptosis of the human cervical cancer line HeL...

    Authors: Wang Yaoxian, Yu Hui, Zhang Yunyan, Liu Yanqin, Ge Xin and Wu Xiaoke

    Citation: Cancer Cell International 2013 13:71

    Content type: Primary research

    Published on:

  19. The breast and ovarian cancer susceptibility gene (BRCA1) encodes a tumor suppressor. The BRCA1 protein is found primarily in cell nuclei and plays an important role in the DNA damage response and transcriptional...

    Authors: Natalie Tulchin, Leonard Ornstein, Steven Dikman, James Strauchen, Shabnam Jaffer, Chandandeep Nagi, Ira Bleiweiss, Ruth Kornreich, Lisa Edelmann, Karen Brown, Carol Bodian, Venugopalan D Nair, Monique Chambon, Nicholas T Woods and Alvaro NA Monteiro

    Citation: Cancer Cell International 2013 13:70

    Content type: Primary research

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  20. Angiogenesis has been an attractive target for drug therapy. Aloin (AL), an natural compound derived from Aloe barbadensis Miller leaves, has been shown to possess anti-cancer potential activities. However, its r...

    Authors: Qin Pan, Hongming Pan, Haizhou Lou, Yinghua Xu and Lu Tian

    Citation: Cancer Cell International 2013 13:69

    Content type: Primary research

    Published on:

  21. MicroRNAs are a class of small non-coding RNAs that play an important role in various human tumor initiation and progression by regulating gene expression negatively. The aim of this study was to investigate t...

    Authors: Ting-Song Yang, Xiao-Hu Yang, Xu-Dong Wang, Yi-Ling Wang, Bo Zhou and Zhen-Shun Song

    Citation: Cancer Cell International 2013 13:68

    Content type: Primary research

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  22. In order to search for new structural modification strategies on fluoroquinolones, we have designed and synthesized a series of fluoroquinolone derivatives by linking various hydrazine compounds to the C-3 car...

    Authors: Jin-ping Sun, Zhen-yu Shi, Shi-meng Liu, Yu-hua Kang, Guo-qiang Hu, Chao-shen Huangfu, Jin-bo Deng and Bin Liu

    Citation: Cancer Cell International 2013 13:67

    Content type: Primary research

    Published on:

  23. Next generation sequencing studies have drawn the general landscape of breast cancers and identified hundreds of new, actual therapeutic targets. Two major signaling pathways seem to be altered in a vast propo...

    Authors: Arnaud Guille, Max Chaffanet and Daniel Birnbaum

    Citation: Cancer Cell International 2013 13:66

    Content type: Hypothesis

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  24. Folate-nanoliposomes delivery system has emerged recently as a specific and safety delivery method and gradually used as the carrier of a variety kinds of drugs including compounds, plasmids and siRNAs.

    Authors: Qiqi Zhu, Chen Feng, Weiwei Liao, Yan Zhang and Suoqin Tang

    Citation: Cancer Cell International 2013 13:65

    Content type: Primary research

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  25. Gallbladder carcinoma is a malignant tumor with a very low 5-year survival rate because of the difficulty with its early diagnosis and the very poor prognosis of the advanced cancer state. The aims of this stu...

    Authors: Tian-Yu Liu, Zhu-Jun Tan, Lin Jiang, Jian-Feng Gu, Xiang-Song Wu, Yang Cao, Mao-Lan Li, Ke-Jin Wu and Ying-Bin Liu

    Citation: Cancer Cell International 2013 13:64

    Content type: Primary research

    Published on:

  26. Apoptosis is a major target and treatment effect of multiple chemotherapeutical agents in cancer. A soybean isoflavone, genistein, is a well-studied chemopreventive agent and has been reported to potentiate th...

    Authors: Xin Xie, Shan Shan Wang, Timothy Chung Sing Wong and Ming Chiu Fung

    Citation: Cancer Cell International 2013 13:63

    Content type: Primary research

    Published on:

  27. Identification of cancer stem cells (CSCs) and their behaviors will provide insightful information for the future control of human cancers. This study investigated CD44 and CD24 cell surface markers as breast ...

    Authors: Wenxing Yan, Yubing Chen, Yueliang Yao, Hongmei Zhang and Tiejun Wang

    Citation: Cancer Cell International 2013 13:62

    Content type: Primary research

    Published on:

  28. The specific mechanism underlying the contribution of the Aldehyde dehydrogenase 1 (ALDH1) phenotype to metastatic behavior and early tumor relapse in breast cancer is currently unclear.

    Authors: Ying Zhong, Yan Lin, Songjie Shen, Yidong Zhou, Feng Mao, Jinghong Guan and Qiang Sun

    Citation: Cancer Cell International 2013 13:60

    Content type: Primary research

    Published on:

  29. The aim of this study was to clarify the clinicopathological outcome of serum relaxin-2 and tissues relaxin-2 expression levels in human primary osteosarcoma (OS), and to explore the roles of relaxin-2 inhibit...

    Authors: Jinfeng Ma, Min Niu, Wenjiu Yang, Lina Zang and Yongming Xi

    Citation: Cancer Cell International 2013 13:59

    Content type: Primary research

    Published on:

  30. R-CHOP has significantly improved survival rates of patients with diffuse large B cell lymphoma (DLBCL) by ~20% as compared to CHOP. CD20 antigen, highly expressed on more than 80% of B-cell lymphomas, is the ...

    Authors: Huirong Ding, Xuan Jin, Ning Ding, Zhiying Fu, Yuqin Song and Jun Zhu

    Citation: Cancer Cell International 2013 13:58

    Content type: Primary research

    Published on:

  31. Epigenetic control using histone deacetylase (HDAC) inhibitors is a promising therapy for lymphomas. Insights into the anti-proliferative effects of HDAC inhibitors on diffuse large B-cell lymphoma (DLBCL) and...

    Authors: Ying Cai, Wenli Cui, Weixiang Chen, Ping Wei, Yayun Chi, Ping Zhang, Rui Bi and Xiaoyan Zhou

    Citation: Cancer Cell International 2013 13:57

    Content type: Primary research

    Published on:

  32. Nowadays it remains a controversial issue whether a correlation exists between the apoptosis rate of tumor tissue and the prognosis of the patients. We aimed to explore the prognostic significance of apoptosis...

    Authors: Xing Wu, Biao Cheng, Zheng-dong Cai and Lie-ming Lou

    Citation: Cancer Cell International 2013 13:56

    Content type: Primary research

    Published on:

  33. For their various bioactivities, biomaterials derived from marine algae are important ingredients in many products, such as cosmetics and drugs for treating cancer and other diseases. This mini-review comprehe...

    Authors: Jin-Ching Lee, Ming-Feng Hou, Hurng-Wern Huang, Fang-Rong Chang, Chi-Chen Yeh, Jen-Yang Tang and Hsueh-Wei Chang

    Citation: Cancer Cell International 2013 13:55

    Content type: Review

    Published on:

  34. Apigenin (4’,5,7-trihydroxyflavone) was recently shown effective in inhibiting several cancers. The aim of this study was to investigate the effect and mechanism of apigenin in the human bladder cancer cell li...

    Authors: Yi Zhu, Yeqing Mao, Hong Chen, Yiwei Lin, Zhenghui Hu, Jian Wu, Xin Xu, Xianglai Xu, Jie Qin and Liping Xie

    Citation: Cancer Cell International 2013 13:54

    Content type: Primary research

    Published on:

  35. The pro-apoptotic Bcl-2 protein BAD initiated apoptosis in human cells and has been identified as a prognostic marker in non-small cell lung cancer (NSCLC). In this study, we aimed to explore the functions of ...

    Authors: Li Jiang, Man Luo, Dan Liu, Bojiang Chen, Wen Zhang, Lin Mai, Jing Zeng, Na Huang, Yi Huang, Xianming Mo and Weimin Li

    Citation: Cancer Cell International 2013 13:53

    Content type: Primary research

    Published on:

  36. Doxorubicin (DOX), an anthracycline antibiotic is one of the most effective anticancer drug used in the treatment of variety of cancers .Its use is limited by its cardiotoxicity. The present study was designed...

    Authors: Abdel-Moneim M Osman, Sameer E Al-Harthi, Ohoud M AlArabi, Mohamed F Elshal, Wafaa S Ramadan, Mohamed N Alaama, Huda M Al-Kreathy, Zoheir A Damanhouri and Osman H Osman

    Citation: Cancer Cell International 2013 13:52

    Content type: Primary research

    Published on:

  37. MicroRNAs (miRNAs) are a large group of negative gene regulators that potentially play a critical role in tumorigenesis. Increasing evidences indicate that miR-145 acts a tumor suppressor in numerous human can...

    Authors: Yuan Shao, Yiping Qu, Siwen Dang, Bowen Yao and Meiju Ji

    Citation: Cancer Cell International 2013 13:51

    Content type: Primary research

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  38. Celastrol, a plant triterpene, is known to play important role in inhibiting proliferation and inducing apoptosis of gastric cancer cells. In the present study, the mechanism of celastrol on gastric cancer cel...

    Authors: Min Sha, Jun Ye, Li-xin Zhang, Zheng-yun Luan and Ya-bao Chen

    Citation: Cancer Cell International 2013 13:50

    Content type: Primary research

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  39. Epidermal growth factor receptor (EGFR) is a member of the receptor tyrosine kinase (RTK) family. Epidermal growth factor induces its dimerization and stimulates phosphorylation of intracellular tyrosine resid...

    Authors: Mi Jeong Jo, Seong Ja Bae, Byeng Wha Son, Chi Yeon Kim and Gun Do Kim

    Citation: Cancer Cell International 2013 13:49

    Content type: Primary research

    Published on:

  40. Up-regulation of heat shock protein 70 (HSP70) could be elicited primarily by heat in former studies, and this was proved to be associated with cancer progression. Burkitt's lymphoma is one of highly aggressiv...

    Authors: Xiaosheng Fang, Yujie Jiang, Lili Feng, Haiping Chen, Changqing Zhen, Mei Ding and Xin Wang

    Citation: Cancer Cell International 2013 13:48

    Content type: Primary research

    Published on:

  41. Cranial radiation therapy has been used for the treatment of primary and metastatic brain tumors. A prominent feature of brain injury induced by the radiation therapy is hippocampal dysfunction, characterized ...

    Authors: Ai-Min Sun, Chuan-Gang Li, Yong-Qing Han, Que-Ling Liu, Qiong Xia and Ya-Wei Yuan

    Citation: Cancer Cell International 2013 13:47

    Content type: Primary research

    Published on:

  42. The multidrug resistance (MDR) 1 gene encodes a 170-kDa membrane transporter called P-glycoprotein, which plays an important role in protecting cells against lipophilic xenobiotics by the way of an ATP-dependent ...

    Authors: Ling-Hui Wang, Yan-Bin Song, Wen-Ling Zheng, Ling Jiang and Wen-Li Ma

    Citation: Cancer Cell International 2013 13:46

    Content type: Primary research

    Published on:

  43. MicroRNAs are small RNA molecules that negatively regulate gene expression by translational inhibition or mRNA cleavage. The discovery that abnormal expression of particular miRNAs contributes to human disease...

    Authors: Sanja Jurcevic, Björn Olsson and Karin Klinga-Levan

    Citation: Cancer Cell International 2013 13:45

    Content type: Primary research

    Published on:

  44. Endometrial cancer (EC) is the most common gynecologic malignancy, but the molecular events involved in the development and progression of EC remain unclear. This study aimed to explore epigenetic modification...

    Authors: Bi-Lan Li, Wen Lu, Cong Lu, Jun-jie Qu, Ting-ting Yang, Qin Yan and Xiao-ping Wan

    Citation: Cancer Cell International 2013 13:44

    Content type: Primary research

    Published on:

  45. We studied the role of caspase-2 in apoptosis induction by taxanes (paclitaxel, novel taxane SB-T-1216) in breast cancer cells using SK-BR-3 (nonfunctional p53, functional caspase-3) and MCF-7 (functional p53,...

    Authors: Michael Jelínek, Kamila Balušíková, Dana Kopperová, Vlasta Němcová-Fürstová, Jan Šrámek, Julie Fidlerová, Ilaria Zanardi, Iwao Ojima and Jan Kovář

    Citation: Cancer Cell International 2013 13:42

    Content type: Primary research

    Published on:

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