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  1. N6-Methyladenosine (m6A) is the most common RNA modification and regulates RNA splicing, translation, translocation, and stability. Aberrant expression of m6A has been reported in various types of human cancers.....

    Authors: Zhi-Hao Yu, Shao-Ting Feng, Di Zhang, Xu-Chen Cao, Yue Yu and Xin Wang
    Citation: Cancer Cell International 2021 21:385
  2. Osteosarcoma was the most common primary bone malignancy in children and adolescents. It was imperative to identify effective prognostic biomarkers for this cancer. This study was aimed to identify potential ...

    Authors: Feng Yao, Zhao Feng Zhu, Jun Wen, Fu Yong Zhang, Zheng Zhang, Lun Qing Zhu, Guang Hao Su, Quan Wen Yuan, Yun Fang Zhen and Xiao Dong Wang
    Citation: Cancer Cell International 2021 21:381
  3. Our previous study shows that LINC01278 inhibits the malignant proliferation and invasion of papillary thyroid carcinoma (PTC) cells by regulating the miR-376c-3p/DNM3 axis. However, the regulation mechanism o...

    Authors: Shaojian Lin, Weiwei Zhang, Ziwen Shi, Langping Tan, Yue Zhu, Honghao Li and Xinzhi Peng
    Citation: Cancer Cell International 2021 21:380
  4. Recently, more and more studies have highlighted the critical regulatory roles of circular RNAs (circRNAs), a class of non-coding RNAs, in the progression of many human cancers, including prostate cancer (PCa)...

    Authors: Deping Yang, Bo Yang, Yanjun Zhu, Qianlin Xia, Yan Zhang, Xin Zhu, Jianming Guo, Tao Ding and Jianghua Zheng
    Citation: Cancer Cell International 2021 21:379
  5. Papillary thyroid carcinoma (PTC) is the most common pathological type of thyroid cancer. The effect of traditional anti-tumor therapy is not ideal for the patients with recurrence, metastasis and radioiodine ...

    Authors: Rujia Qin, Chunyan Li, Xuemin Wang, Zhaoming Zhong and Chuanzheng Sun
    Citation: Cancer Cell International 2021 21:378
  6. This study aimed to identify novel targets in the carcinogenesis, therapy and prognosis of osteosarcoma from genomic level, together with screening ideal lead compounds with potential inhibition regarding MMP-9.

    Authors: Weihang Li, Ziyi Ding, Dong Wang, Chengfei Li, Yikai Pan, Yingjing Zhao, Hongzhe Zhao, Tianxing Lu, Rui Xu, Shilei Zhang, Bin Yuan, Yunlong Zhao, Yanjiang Yin, Yuan Gao, Jing Li and Ming Yan
    Citation: Cancer Cell International 2021 21:377
  7. Gastric cancer (GC) remains an important cancer worldwide. Further understanding of the molecular mechanisms of gastric carcinogenesis will enhance the diagnosis and treatment of GC.

    Authors: Shuyi Han, Yan Qi, Yihui Xu, Min Wang, Jun Wang, Jing Wang, Mingjie Yuan, Yanfei Jia, Xiaoli Ma, Yunshan Wang and Xiangdong Liu
    Citation: Cancer Cell International 2021 21:376
  8. Deubiquitinating enzymes (DUBs) play critical roles in various cancers by modulating functional proteins post-translationally. Previous studies have demonstrated that DUB Josephin Domain Containing 1 (JOSD1) i...

    Authors: Chao Jing, Dandan Liu, Qingchuan Lai, Linqi Li, Mengqian Zhou, Beibei Ye, Yue Wu, Hong Li, Kai Yue, Yansheng Wu, Yuansheng Duan and Xudong Wang
    Citation: Cancer Cell International 2021 21:375
  9. Hepatocyte growth factor (HGF) binds to the c-mesenchymal-epithelial transition (C-MET) receptor and activates downstream signaling pathways, playing an essential role in the development of various cancers. Gi...

    Authors: Zhibo Shen, Wenhua Xue, Yuanyuan Zheng, Qishun Geng, Le Wang, Zhirui Fan, Wenbin Wang, Ying Yue, Yunkai Zhai, Lifeng Li and Jie Zhao
    Citation: Cancer Cell International 2021 21:374

    The Correction to this article has been published in Cancer Cell International 2021 21:672

  10. Bone is the most common site of metastatic breast cancer, and it is a leading cause of breast cancer-related death. This study aimed to explore bone metastasis-related long non-coding RNAs (lncRNAs) in breast ...

    Authors: Yu Zhang, Xiaofeng Huang, Jin Liu, Guo Chen, Chengjun Liu, Sen Zhang and Jiaxin Li
    Citation: Cancer Cell International 2021 21:372
  11. Programmed death- ligand 1 (PD-L1) seems to be associated with the immune escape of tumors, and immunotherapy may be a favorable treatment for PD-L1-positive patients. We evaluated intrahepatic cholangiocarcin...

    Authors: Min Deng, Shao-Hua Li, Xu Fu, Xiao-Peng Yan, Jun Chen, Yu-Dong Qiu and Rong-Ping Guo
    Citation: Cancer Cell International 2021 21:371
  12. LncRNA prostate cancer-associated transcript 6 (PCAT6) has been reported to be dysregulated in several cancers and is associated with tumor progression. Here, we have performed a meta-analysis to assess the ge...

    Authors: Song-bo Shi, Qing-hao Cheng, Shi-yi Gong, Ting-ting Lu, Shi-fang Guo, Shao-ming Song, Yu-ping Yang, Qi Cui, Ke-hu Yang and Yao-wen Qian
    Citation: Cancer Cell International 2021 21:370
  13. Epstein-Barr virus-associated gastric cancer (EBVaGC) is the most common EBV-related malignancy. A comprehensive research for the protein expression patterns in EBVaGC established by high-throughput assay rema...

    Authors: Zeyang Wang, Zhi Lv, Qian Xu, Liping Sun and Yuan Yuan
    Citation: Cancer Cell International 2021 21:368
  14. Long non-coding RNAs (lncRNAs) are vital regulators of gene expression and cellular processes in multiple cancers, including melanoma. Nevertheless, the function of lncRNA NCK1-antisense 1 (NCK1-AS1) in melano...

    Authors: Quan Lin, Yan Jia, Duo Zhang and Hongjuan Jin
    Citation: Cancer Cell International 2021 21:367
  15. Peroxiredoxins (PRDXs) are an antioxidant enzymes protein family involved in several biological functions such as differentiation, cell growth. In addition, previous studies report that PRDXs play critical rol...

    Authors: Lei Gao, Jialin Meng, Chuang Yue, Xingyu Wu, Quanxin Su, Hao Wu, Ze Zhang, Qinzhou Yu, Shenglin Gao, Song Fan and Li Zuo
    Citation: Cancer Cell International 2021 21:366
  16. Uterus corpus endometrial cancer (UCEC) is the main malignant tumor in gynecology, with a high degree of heterogeneity, especially in terms of prognosis and immunotherapy efficacy. DNA methylation is one of th...

    Authors: JinHui Liu, ChengJian Ji, Yichun Wang, Cheng Zhang and HongJun Zhu
    Citation: Cancer Cell International 2021 21:365
  17. Exosomes are single-membrane, secreted organelles with a diameter of 30–200 nm, containing diverse bioactive constituents, including DNAs, RNAs, proteins, and lipids, with prominent molecular heterogeneity. Ex...

    Authors: Zheng Zhao, Guiping Zhao, Shuyue Yang, Shengtao Zhu, Shutian Zhang and Peng Li
    Citation: Cancer Cell International 2021 21:364
  18. Both N6-methyladenosine (m6A) modification and lncRNAs play an important role in the carcinogenesis and cancer inhibition of ovarian cancer (OC). However, lncRNAs involved in m6A regulation (LI-m6As) have neve...

    Authors: Jianfeng Zheng, Jialu Guo, Benben Cao, Ying Zhou and Jinyi Tong
    Citation: Cancer Cell International 2021 21:363
  19. Growing evidence has shown that long noncoding RNA: microRNA: mRNA is implicated in tumor initiation, development, and progression. Long noncoding RNA HAND2-AS1 exhibits anti-cancer effects in diverse cancers....

    Authors: Liping Shan, Wei Liu and Yunhong Zhan
    Citation: Cancer Cell International 2021 21:361
  20. Long non-coding RNAs (lncRNAs) and microRNAs (miRs) are differentially expressed in ovarian cancer (OC) cells and influence OC progression. This study intended to explore the underlying roles of LINC00115 and ...

    Authors: Rui Hou and Luo Jiang
    Citation: Cancer Cell International 2021 21:360
  21. A large number of patients with stage II/III colorectal cancer (CRC) have a high recurrence rate after radical resection. We aimed to develop a novel tool to stratify patients with different recurrence-risk fo...

    Authors: Zaoqu Liu, Taoyuan Lu, Jing Li, Libo Wang, Kaihao Xu, Qin Dang, Chunguang Guo, Long Liu, Dechao Jiao, Zhenqiang Sun and Xinwei Han
    Citation: Cancer Cell International 2021 21:359
  22. Because its metastasis to the lymph nodes are closely related to poor prognosis, miRNAs and mRNAs can serve as biomarkers for the diagnosis, prognosis, and therapy of colorectal cancer (CRC). This study aimed ...

    Authors: Xi Wang, Guangyu Gao, Zhengrong Chen, Zhihao Chen, Mingxiao Han, Xiaolu Xie, Qiyuan Jin, Hong Du, Zhifei Cao and Haifang Zhang
    Citation: Cancer Cell International 2021 21:358
  23. In view of the fact that peripheral blood parameters have been reported as predictors of immunotherapy to various cancers, this study aimed to determine the predictors of response to anti-programmed death-1 (a...

    Authors: Xianbin Wu, Runkun Han, Yanping Zhong, Nuoqing Weng and Ao Zhang
    Citation: Cancer Cell International 2021 21:356

    The Correction to this article has been published in Cancer Cell International 2021 21:693

  24. Clear cell renal cell carcinoma (ccRCC) occupied most of renal cell carcinoma (RCC), which associated with poor prognosis. The purpose of this study is to screen novel and prognostic biomarkers for patients wi...

    Authors: Hua-Hui Wu, Xin Yan, Zhao Chen, Guo-Wei Du, Xiao-Jie Bai, Kurerban Tuoheti and Tong-Zu Liu
    Citation: Cancer Cell International 2021 21:354
  25. Ovarian cancer (OC) is the most lethal gynaecological tumor. Changes in glycolysis have been proven to play an important role in OC progression. We aimed to identify a novel glycolysis-related gene signature t...

    Authors: Jing Yu, Ting-Ting Liu, Lei-Lei Liang, Jing Liu, Hong-Qing Cai, Jia Zeng, Tian-Tian Wang, Jian Li, Lin Xiu, Ning Li and Ling-Ying Wu
    Citation: Cancer Cell International 2021 21:353
  26. Long non-coding RNAs (lncRNAs), acting as competing endogenous RNA (ceRNA) have been reported to regulate the expression of targeted genes by sponging miRNA in colon adenocarcinoma (COAD).

    Authors: Yinling Mao, Jiachen Lv, Li Jiang and Yihui Wang
    Citation: Cancer Cell International 2021 21:352
  27. Type 2 diabetes mellitus and breast cancer are complex, chronic, heterogeneous, and multi-factorial diseases; with common risk factors including but not limited to diet, obesity, and age. They also share mutua...

    Authors: Ilhaam Ayaz Durrani, Attya Bhatti and Peter John
    Citation: Cancer Cell International 2021 21:351
  28. The mitochondrion is an organelle that plays a vital role in energy production, cytoplasmic protein degradation and cell death. Mitophagy is an autophagic procedure that specifically clears damaged mitochondri...

    Authors: Yanjie Guan, Yifei Wang, Bo Li, Kai Shen, Quanfu Li, Yingyin Ni and Lei Huang
    Citation: Cancer Cell International 2021 21:350
  29. Osteosarcoma is a primary bone tumor. Although it is a rare disease in general, it is the most common primary bone tumor among children. Despite the significant advances made in the field of osteosarcoma treat...

    Authors: Parisa Maleki Dana, Fatemeh Sadoughi, Zatollah Asemi and Bahman Yousefi
    Citation: Cancer Cell International 2021 21:349
  30. Mature T-cell lymphomas (MTCLs), a group of diseases with high aggressiveness and vulnerable prognosis, lack for the accurate prognostic stratification systems at present. Novel prognostic markers and models a...

    Authors: Tiange Lu, Lei Shi, Guanggang Shi, Yiqing Cai, Shunfeng Hu, Jiarui Liu, Shuai Ren, Xiangxiang Zhou and Xin Wang
    Citation: Cancer Cell International 2021 21:348
  31. Glioblastoma remains one of the most lethal brain cancers. T-cell immunoglobulin and mucin domain 1 (Tim-1) is associated with various immune diseases. The molecular mechanism of Tim-1 in regulating glioblasto...

    Authors: Li Wei, Ya Peng, Naiyuan Shao and Peng Zhou
    Citation: Cancer Cell International 2021 21:347
  32. Methylation plays an important role in colorectal cancer (CRC) pathogenesis. The goal of this study was to identify aberrantly differentially methylated genes (DMGs) and pathways through bioinformatics analysi...

    Authors: Mahla Ghorbani, Marjan Azghandi and Mohammad Amin Kerachian
    Citation: Cancer Cell International 2021 21:346
  33. Hypoxia, which affects the development, metastasis and prognosis of cancer, represents a key feature of cancer. This study describe a hypoxia risk factor model, with predicting the prognosis of cervical cancer.

    Authors: Yang Yang, Yaling Li, Ruiqun Qi and Lan Zhang
    Citation: Cancer Cell International 2021 21:345
  34. Although immunotherapy for colon cancer has made promising progress, only a few patients currently benefit from it. A recent study revealed that infiltrating immune cells are highly relevant to tumor prognosis...

    Authors: Hao Xu, Qianhui Xu and Lu Yin
    Citation: Cancer Cell International 2021 21:344
  35. Clear cell renal cell carcinoma (ccRCC), derived from renal tubular epithelial cells, is the most common malignant tumor of the kidney. The study of key genes related to the pathogenesis of ccRCC has become im...

    Authors: Chunxiu Yang, Jingjing Pang, Jian Xu, He Pan, Yueying Li, Huainian Zhang, Huan Liu and Shu-Yuan Xiao
    Citation: Cancer Cell International 2021 21:343
  36. Hepatocellular carcinoma (HCC) was the sixth common malignancies characteristic with highly aggressive in the world. It was well established that tumor mutation burden (TMB) act as indicator of immunotherapeut...

    Authors: Qianhui Xu, Hao Xu, Rongshan Deng, Zijie Wang, Nanjun Li, Zhixuan Qi, Jiaxin Zhao and Wen Huang
    Citation: Cancer Cell International 2021 21:342
  37. Aryl hydrocarbon receptor nuclear translocator like 2 (ARNTL2) is a member of the PAS superfamily. Previous studies explored the carcinogenic roles of transcription factor ARNTL2 in human malignancies. However...

    Authors: Song Wang, Xueyou Ma, Yufan Ying, Jiazhu Sun, Zitong Yang, Jiangfeng Li, Ke Jin, Xiao Wang, Bo Xie, Xiangyi Zheng, Ben Liu and Liping Xie
    Citation: Cancer Cell International 2021 21:341
  38. Long non-coding RNAs (lncRNAs) are increasingly recognized as the crucial mediators in the regulation of ferroptosis and iron metabolism. A systematic understanding of ferroptosis and iron-metabolism related l...

    Authors: Jie Yao, Xiao Chen, Xiao Liu, Rui Li, Xijia Zhou and Yiqing Qu
    Citation: Cancer Cell International 2021 21:340
  39. Fatty acid oxidation (FAO) is the emerging hallmark of cancer metabolism because certain tumor cells preferentially utilize fatty acids for energy. Lymph node metastasis, the most common way of tumor metastasi...

    Authors: Mao Li, Hong-chun Xian, Ya-Jie Tang, Xin-hua Liang and Ya-ling Tang
    Citation: Cancer Cell International 2021 21:339
  40. Some driver oncogenes are still unknown in non-small-cell lung cancer (NSCLC). DNAJC19, a major component of the translocation machinery of mitochondrial membranes, is a disease-associated protein. Herein, we ...

    Authors: Ji Zhou, Yang Peng, Ying-chun Gao, Tai-yu Chen, Peng-cheng Li, Ke Xu, Tao Liu and Tao Ren
    Citation: Cancer Cell International 2021 21:338
  41. Additional epidermal growth factor receptor (EGFR) mutations confer the drug resistance to generations of EGFR targeted tyrosine kinase inhibitor (EGFR-TKI), posing a major challenge to developing effective tr...

    Authors: Leiming Xia, Fan Yang, Xiao Wu, Suzhi Li, Chen Kan, Hong Zheng and Siying Wang
    Citation: Cancer Cell International 2021 21:337
  42. Osteosarcoma (OS) is a common type of bone malignancy that often occurs in children and adolescents. Chemoresistance is a huge barrier to cancer therapy. This study aimed to investigate the role and potential ...

    Authors: Huapeng Guan, Hao Xu, Jinshui Chen, Weishan Wu, Dongfeng Chen, Yungang Chen and Jianzhong Sun
    Citation: Cancer Cell International 2021 21:336
  43. Gastric cancer (GC) is one of the most common cancer worldwide. It is essential to identify non-invasive diagnostic and prognostic biomarkers of GC. The aim of the present study was to screen candidate biomark...

    Authors: Lei Liu, Honglin Pang, Qiao He, Biran Pan, Xiaobin Sun, Jing Shan, Liping Wu, Kaiwen Wu, Xue Yao and Yuanbiao Guo
    Citation: Cancer Cell International 2021 21:335
  44. Patients with nasopharyngeal cancer (NPC) differ in prognosis, even at the same stage; therefore, new biomarkers are urgently required to identify early-stage NPC patients at high risk of poor prognosis. Altho...

    Authors: Tianhao Liang, Weixing Liu, Junyang Xie, Yiyan Wang, Gui Chen, Wenjing Liao, Lijuan Song and Xiaowen Zhang
    Citation: Cancer Cell International 2021 21:329

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