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  1. Galangin (3,5,7-trihydroxyflavone) is a flavonoid compound found in high concentration in lesser galangal. The objective of this study was to investigate the ability of galangin to inhibit 12-O-tetradecanoylph...

    Authors: Shang-Tao Chien, Ming-Der Shi, Yi-Chieh Lee, Chou-Chia Te and Yuan-Wei Shih

    Citation: Cancer Cell International 2015 15:15

    Content type: Primary research

    Published on:

  2. An area of research that has been recently gaining attention is the relationship between cancer stem cell (CSC) biology and chemo-resistance in colon cancer patients. It is well recognized that tumor initiatio...

    Authors: Elsa N Garza-Treviño, Salvador L Said-Fernández and Herminia G Martínez-Rodríguez

    Citation: Cancer Cell International 2015 15:2

    Content type: Review

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  3. Tumour cells show greater dependency on glycolysis so providing a sufficient and rapid energy supply for fast growth. In many breast cancers, estrogen, progesterone and epidermal growth factor receptor-positiv...

    Authors: Simon Taylor, Matthew Lam, Chathyan Pararasa, James EP Brown, Amtul R Carmichael and Helen R Griffiths

    Citation: Cancer Cell International 2015 15:1

    Content type: Review

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  4. There is limited information on a special subtype of Acute myeloid leukemia (AML) characterized by >20% myeloblasts and >20% abnormal promyelocytes in bone marrow and peripheral blood.

    Authors: GanLin He, ChunYan Wang, QingEn Li, Huo Tan, FuXiong Chen, ZhenQian Huang, BaoDan Yu, LiXia Zheng, RunHui Zheng and Dan Liu

    Citation: Cancer Cell International 2014 14:111

    Content type: Primary research

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  5. T cell-mediated immunity plays an important role in enhancing antitumor response.This study aimed to investigate the changes in the T-lymphocyte subpopulation and to characterize the differential expression pa...

    Authors: Qingsong Yin, Lin Chen, Qianyu Li, Ruihua Mi, Yufu Li, Xudong Wei and Yongping Song

    Citation: Cancer Cell International 2014 14:85

    Content type: Primary research

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  6. Recent studies suggested that leptin as a mitogenic factor might play an important role in the process of initiation and progression of human cancer. Therefore, it could be considered as a target for breast ca...

    Authors: Kazem Nejati-Koshki, Abolfazl Akbarzadeh and Mohammad Pourhassan-Moghaddam

    Citation: Cancer Cell International 2014 14:66

    Content type: Primary research

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  7. Recently a sub-population of cells with stem cell characteristics, reported to be associated with initiation, growth, spread and recurrence, has been identified in several solid tumors including oral tongue sq...

    Authors: Saira Saleem, Arif Jamshed, Saima Faisal, Raza Hussain, Muhammad Tahseen, Asif Loya and Chris Sutton

    Citation: Cancer Cell International 2014 14:542

    Content type: Primary research

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  8. A key strategy for the study of the tumor microenvironment is to implant human tumor cells in an immunodeficient rodent strain ubiquitously expressing a fluorescent marker. Here, a novel nude rat expressing a ...

    Authors: Ning Yang, Bin Huang, Oleg Tsinkalovsky, Narve Brekkå, Huaiyang Zhu, Lina Leiss, Per Øyvind Enger, Xingang Li and Jian Wang

    Citation: Cancer Cell International 2014 14:541

    Content type: Primary research

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  9. Several signal transduction pathways have been reported being involved in the acquisition of P-glycoprotein (P-gp) mediated multi-drug resistance (MDR) upon exposure to anti-cancer drugs, whereas there is evid...

    Authors: Feifei Xu, Fengliang Wang, Ting Yang, Yuan Sheng, Ting Zhong and Yun Chen

    Citation: Cancer Cell International 2014 14:538

    Content type: Primary research

    Published on:

  10. Endometrial carcinoma is one of the most common gynecologic malignancies. Estrogen plays a critical role in its pathogenesis, but the underlying mechanism is not clear. Nucleophosmin 1 (NPM1), a multifunctiona...

    Authors: Yunxiao Zhou, Jie Shen, Liqun Xia and Yanli Wang

    Citation: Cancer Cell International 2014 14:540

    Content type: Primary research

    Published on:

  11. Photodynamic therapy (PDT) is becoming a promising therapeutic modality for hematological malignancies. Hypericin is a natural photosensitizer possessing anti-depressant, anti-virus and anti-cancer activities....

    Authors: Junping Zhang, Linxiang Shao, Chunlin Wu, Hongfei Lu and Ruian Xu

    Citation: Cancer Cell International 2014 14:136

    Content type: Primary research

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  12. Photodynamic therapy (PDT) is becoming a promising therapeutic modality for hematological malignancies. Hypericin is a natural photosensitizer possessing anti-depressant...

    Authors: Junping Zhang, Linxiang Shao, Chunlin Wu, Hongfei Lu and Ruian Xu

    Citation: Cancer Cell International 2014 15:58

    Content type: Primary research

    Published on:

    The Retraction Note to this article has been published in Cancer Cell International 2015 15:66

  13. To evaluate the balance between T-cell immunoglobulin and mucin domain (Tim) molecules(Tim)-1 and Tim-3 in patients with aplastic anemia (AA), plasma IFN-γ and IL-4 levels were measured in patients with active...

    Authors: Xin Liu, Xin Cui, Dai Yuan, Ying Li, Ning-ning Shan, Xin Wang and Yu Hu

    Citation: Cancer Cell International 2014 14:144

    Content type: Primary research

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  14. H2AX is phosphorylated (γH2AX) by members of the phosphatidylinositol 3-kinase (PI3K) family, including Ataxia telangiectasia-mutated (ATM), ATM- and Rad3-related (ATR) and DNA-PK in response to DNA damage. Ou...

    Authors: Zhong Guo, Jin Zhao, Lei Song, Jian-Xiu Ma, Chen-Jing Wang, Shu-Yan Pei, Chao Jiang and Shang-Biao Li

    Citation: Cancer Cell International 2014 14:141

    Content type: Primary research

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  15. Both microRNA (miR)-196a and miR-196b are implicated in normal cell differentiation, proliferation, and in tumorigenesis of various cancer types. Especially, miR-196a exerts a pro-oncogenic influence in colore...

    Authors: Jie Ge, Zihua Chen, Ruixing Li, Tailiang Lu and Guangfa Xiao

    Citation: Cancer Cell International 2014 14:128

    Content type: Primary research

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  16. Esophageal squamous cell carcinoma (ESCC) is one of the most common and deadly forms of cancer. Despite advances in the diagnosis and treatment of this cancer, the survival rate at five years is poor. Lately, ...

    Authors: Chao Yang, Siqing Ning, Zhaoyuan Li, Xiaomin Qin and Wei Xu

    Citation: Cancer Cell International 2014 14:138

    Content type: Primary research

    Published on:

  17. Epidermal growth factor (EGF) plays a pivotal role in cell proliferation, differentiation, and tumorigenesis of epithelial tissues. Variation of the EGF +61A/G (rs4444903) can lead to an alteration in EGF prod...

    Authors: Qiliu Peng, Shan Li, Xue Qin, Xianjun Lao, Zhiping Chen, Xiaolian Zhang and Junqiang Chen

    Citation: Cancer Cell International 2014 14:134

    Content type: Primary research

    Published on:

  18. Multiple myeloma is a hematologic malignancy characterized by the accumulation of monoclonal plasma cells in the bone marrow. A common manifestation of the disease is myeloma bone disease (MBD), which is cause...

    Authors: Rong Fu, Hui Liu, Sijie Zhao, Yihao Wang, Lijuan Li, Shan Gao, Erbao Ruan, Guojin Wang, Huaquan Wang, Jia Song and Zonghong Shao

    Citation: Cancer Cell International 2014 14:132

    Content type: Primary research

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  19. This study provided additional data on the effects of a therapeutic electromagnetic field (EMF) device on growth and vascularization of murine 16/C mammary adenocarcinoma cells implanted in C3H/HeJ mice.

    Authors: Ivan L Cameron, Marko S Markov and W Elaine Hardman

    Citation: Cancer Cell International 2014 14:125

    Content type: Primary research

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  20. Treatment with imatinib mesylate (IM) (a tyrosine kinase inhibitor) is the first line of standard care for patients newly diagnosed with CML. Despite the success of IM and other tyrosine kinase inhibitors (TKI...

    Authors: Changshu Cao, Bailian Liu, Chengwu Zeng, Yuhong Lu, Shaohua Chen, Lijian Yang, Bo Li, Yaolan Li and Yangqiu Li

    Citation: Cancer Cell International 2014 14:137

    Content type: Primary research

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  21. Persistent infection of Mycoplasma hyorhinis (M. hyorhinis) was associated with gastric cancer cell migration and invasion, but the mechanisms were not well understood. Herein, we found that M. hyorhinis activate...

    Authors: Hongying Duan, Like Qu and Chengchao Shou

    Citation: Cancer Cell International 2014 14:135

    Content type: Primary research

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  22. Burkitt’s lymphoma is an aggressive malignancy with high risk of metastasis to extranodal sites, such as bone marrow and central nervous system. The prognosis of metastatic Burkitt’s lymphoma is poor. Here we ...

    Authors: Ning Ding, Lingyan Ping, Lixia Feng, Xiaohui Zheng, Yuqin Song and Jun Zhu

    Citation: Cancer Cell International 2014 14:2

    Content type: Primary research

    Published on:

  23. Despite the modern therapies available for treating glioblastoma multiforme (GBM), it is still a deadly disease. The development of new therapeutic strategies for the management of gliomas is therefore crucial...

    Authors: Farina Hanif, Kahkashan Perveen, Huma Jawed, Aqeel Ahmed, Saima M Malhi, Siddiqua Jamall and Shabana U Simjee

    Citation: Cancer Cell International 2014 14:133

    Content type: Primary research

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  24. Cell cycle regulatory pathway is a well-established pathway mainly dependent on cyclin-dependent kinases (CDKs), which are regulated positively by cyclins and negatively by cyclin-dependent kinase inhibitors(C...

    Authors: Xiangming He, Hua Xiang, Xiangyun Zong, Xuebing Yan, Yang Yu, Guan Liu, Dehong Zou and Hongjian Yang

    Citation: Cancer Cell International 2014 14:130

    Content type: Primary research

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  25. Epithelial mesenchymal transition (EMT) is thought to be an essential feature of malignant tumor cells when they spread into the stroma. Despite the extracellular acidity of tumor tissues, the effect of acidic...

    Authors: Atsuko Suzuki, Toyonobu Maeda, Yuh Baba, Kazuhiro Shimamura and Yasumasa Kato

    Citation: Cancer Cell International 2014 14:129

    Content type: Primary research

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  26. The null genotype of GSTM1 have been implicated in gastric cancer risk, but numerous individual studies showed mixed, or even conflicting results. Thus, a meta-analysis was performed.

    Authors: Xianjun Lao, Qiliu Peng, Yu Lu, Shan Li, Xue Qin, Zhiping Chen and Junqiang Chen

    Citation: Cancer Cell International 2014 14:127

    Content type: Primary research

    Published on:

  27. The mechanism underlying the differential cytotoxicity of curcumin in various cancer types, however, remains largely unclear. The aims of this study is to examine the concentration- and time-related effects of...

    Authors: Tao Jia, Li Zhang, Yale Duan, Min Zhang, Gang Wang, Jun Zhang and Zheng Zhao

    Citation: Cancer Cell International 2014 14:126

    Content type: Primary research

    Published on:

  28. Progress in our understanding of molecular oncology has started to shed light on dysregulation of spatio-temporally controlled signaling pathways, inactivation of tumor suppressor genes, tumour and normal stem...

    Authors: Aliye Aras Perk, Iryna Shatynska-Mytsyk, Yusuf Can Gerçek, Kadir Boztaş, Mevzule Yazgan, Sundas Fayyaz and Ammad Ahmad Farooqi

    Citation: Cancer Cell International 2014 14:124

    Content type: Review

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  29. Concurrent study of secretomic and glycoproteomic profiles in cancer cell lines represents an excellent approach for investigating cancer progression and identifying novel biomarker candidates. In this study, ...

    Authors: Aik-Aun Tan, Alan Kang-Wai Mu, Lik-Voon Kiew and Yeng Chen

    Citation: Cancer Cell International 2014 14:120

    Content type: Primary research

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  30. The inevitable side effects of the currently used chemotherapy are associated with serious syndromes. Genotoxic effects and consequent genetic instability may play an important role in these syndromes. The aim...

    Authors: Nasir Kamat, Mohammed A Khidhir, Sabir Hussain, Mouied M Alashari and Ulf Rannug

    Citation: Cancer Cell International 2014 14:118

    Content type: Primary research

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  31. Though ergosterol peroxide (EP) derived from Neungyi mushrooms (Sarcodon aspratus) was known to have cytotoxic, apoptotic, anti-inflammatory and antimycobacterial effects, the underlying molecular mechanism of EP...

    Authors: Jonghyun Han, Eun Jung Sohn, Bonglee Kim, Sunhee Kim, Gunho Won, Sangwook Yoon, Jihyun Lee, Moon Joon Kim, Hojin Lee, Kyujin Chung and Sung-hoon Kim

    Citation: Cancer Cell International 2014 14:117

    Content type: Primary research

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  32. According to contemporary epidemiological and experimental evidence, we propose a novel classification of cancers based on pathogenesis instead of classifications based on histological appearance of cancer. Th...

    Authors: Carlos Sonnenschein, Barbara Davis and Ana M Soto

    Citation: Cancer Cell International 2014 14:113

    Content type: Review

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  33. Erlotinib is a novel therapeutic agent for cancer treatment. This study was performed to investigate the role of c-MET-PI3K-AKT pathway in the regulation of erlotinib-induced radiosensitization.

    Authors: Hong-Qing Zhuang, Hongxia Zhuang, Qifu Bo, Yihang Guo, Jun Wang, Lu-Jun Zhao, Zhi-Yong Yuan and Ping Wang

    Citation: Cancer Cell International 2014 14:109

    Content type: Primary research

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  34. Accumulating studies have focused on the oncogenic and tumor suppressive roles of the newly identified lncRNAs. A novel lncRNA BC040587 in 3q13.31 locus which exists frequent copy number alterations was found ...

    Authors: Yayun Chi, Sheng Huang, Lin Yuan, Mengying Liu, Naisi Huang, Shuling Zhou, Bingqing Zhou and Jiong Wu

    Citation: Cancer Cell International 2014 14:123

    Content type: Primary research

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  35. Tumour homing capacity of engineered human adipose-derived mesenchymal stromal cells (ADMSCs) expressing anti-tumour agents might be the key for a much safer and yet efficient targeted tumour therapy. However,...

    Authors: Kamal Shaik Fakiruddin, Puteri Baharuddin, Moon Nian Lim, Noor Atiqah Fakharuzi, Nurul Ain Nasim M Yusof and Zubaidah Zakaria

    Citation: Cancer Cell International 2014 14:122

    Content type: Primary research

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  36. MicroRNAs (miRNA) are small non-coding RNAs that play an important role in the control of gene expression by inhibiting protein translation or promoting messenger RNA degradation. Today, miRNAs have been shown...

    Authors: Denis R Morais, Sabrina T Reis, Nayara Viana, Camila Berfort Piantino, Cristina Massoco, Caio Moura, Nelson Dip, Iran A Silva, Miguel Srougi and Katia RM Leite

    Citation: Cancer Cell International 2014 14:119

    Content type: Primary research

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  37. Non-B cell immunoglobulins (Igs) are widely expressed in epithelial cancer cells. The past 20 years of research have demonstrated that non-B cell Igs are associated with cancer cell proliferation, the cellular...

    Authors: Lina Wu, Yang Liu, Xiaohui Zhu, Li Zhang, Jinfeng Chen, Hong Zhang, Peng Hao, Shuai Zhang, Jing Huang, Jie Zheng, Yingmei Zhang, Youhui Zhang and Xiaoyan Qiu

    Citation: Cancer Cell International 2014 14:114

    Content type: Primary research

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  38. Suberoylanilide hydroxamic acid (SAHA) is a member of the hydroxamic acid class of the newly developed histone deacetylase inhibitors. Recently, Suberoylanilide hydroxamic acid has attracted increasing attenti...

    Authors: Zhaohui Liu, Ying Tong, Yuanlin Liu, Huaping Liu, Chundong Li, Yue Zhao and Yi Zhang

    Citation: Cancer Cell International 2014 14:112

    Content type: Primary research

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  39. Epiregulin (EPR) is a novel member of the epidermal growth factor (EGF) family. It has been shown to promote wound healing in oral epithelium, enhance proliferation of other epithelial tissues, and is involved...

    Authors: Darren Chyi-Hsiang Kong, Kenneth Yee Choy Chew, Eng Lai Tan and Suan Phaik Khoo

    Citation: Cancer Cell International 2014 14:65

    Content type: Primary research

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  40. MicroRNAs are small non-coding RNAs that play crucial roles in the pathogenesis of different cancer types. The aim of this study was to identify miRNAs that are differentially expressed in endometrial adenocar...

    Authors: Sanja Jurcevic, Björn Olsson and Karin Klinga-Levan

    Citation: Cancer Cell International 2014 14:88

    Content type: Primary research

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  41. Undifferentiated embryonic cell transcription factor-1 (UTF1) plays a critical role in the developmental timing during embryonic development. However, there is little paper dealing with UTF1 expressed in adult...

    Authors: Chaoyang Xu, Ying Zhou and Wei Chen

    Citation: Cancer Cell International 2014 14:116

    Content type: Primary research

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  42. The US National Cancer Institute (NCI) and the National Human Genome Research Institute (NHGRI) created the Cancer Genome Atlas (TCGA) Project in 2006. The TCGA’s goal was to sequence the genomes of 10,000 tum...

    Authors: Shengwen Calvin Li, Lisa May Ling Tachiki, Mustafa H Kabeer, Brent A Dethlefs, Michael J Anthony and William G Loudon

    Citation: Cancer Cell International 2014 14:115

    Content type: Review

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  43. Suberoyl bis-hydroxamic acid (SBHA) is a histone deacetylase (HDAC) inhibitor and exerts anti-growth effects in several malignancies including breast cancer. Proteasome inhibitors such as Bortezomib and MG-132...

    Authors: Xinmiao Yang, Zeliang Shi, Ning Zhang, Zhouluo Ou, Shen Fu, Xichun Hu and Zhenzhou Shen

    Citation: Cancer Cell International 2014 14:107

    Content type: Primary research

    Published on:

  44. Growth factor mediated activation of RAS-MAP-kinase and PI3-kinase-AKT pathways are critical for the pathogenesis of glioblastoma. The attenuation of PI3-kinase/AKT signaling will be effective in regulating th...

    Authors: Alok R Singh, Shweta Joshi, Elizabeth George and Donald L Durden

    Citation: Cancer Cell International 2014 14:105

    Content type: Primary research

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  45. The cancer microenvironment has a strong impact on the growth and dynamics of cancer cells. Conventional 2D culture systems, however, do not reflect in vivo conditions, impeding detailed studies of cancer cell dy...

    Authors: Laura P Ivers, Brendan Cummings, Funke Owolabi, Katarzyna Welzel, Rut Klinger, Sayaka Saitoh, Darran O’Connor, Yasuyuki Fujita, Dimitri Scholz and Nobue Itasaki

    Citation: Cancer Cell International 2014 14:108

    Content type: Primary research

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  46. Ursolic acid (UA), a plant extract used in traditional Chinese medicine, exhibits potential anticancer effects in various human cancer cell lines in vitro. In the present study, we evaluated the anti-tumoral prop...

    Authors: Hao Weng, Zhu-Jun Tan, Yun-Ping Hu, Yi-Jun Shu, Run-Fa Bao, Lin Jiang, Xiang-Song Wu, Mao-Lan Li, Qian Ding, Xu-an Wang, Shan-shan Xiang, Huai-Feng Li, Yang Cao, Feng Tao and Ying-Bin Liu

    Citation: Cancer Cell International 2014 14:96

    Content type: Primary research

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