Skip to main content

Articles

Page 28 of 41

  1. PDZ binding-kinase (PBK) (also named T-lymphokine-activated killer cell-originated protein kinase (TOPK)), a serine/threonine kinase, is tightly controlled in normal tissues but elevated in many tumors, and fu...

    Authors: Xiaoyan Dou, Jing Wei, Aiqin Sun, Genbao Shao, Chandra Childress, Wannian Yang and Qiong Lin

    Citation: Cancer Cell International 2015 15:27

    Content type: Primary research

    Published on:

  2. Duguelin is a rotenoid extracted from plants and has potent antitumor effects in vitro and in vivo. However, the mechanism underlying the antitumor effect remains unclear. Our preliminary study showed that Deg...

    Authors: Huae Xu, Xiaolin Li, Wenqiu Ding, Xiaoning Zeng, Hui Kong, Hong Wang and Weiping Xie

    Citation: Cancer Cell International 2015 15:25

    Content type: Primary research

    Published on:

  3. Emerging evidence indicates that dysregulated long intervening non-coding RNA (lincRNA) HOTAIR correlates highly with tumor invasion and metastasis but a link between the high expression of HOTAIR and the meta...

    Authors: Jing Wang, Dengyu Chen, Xiangfeng He, Yuxia Zhang, Fangfang Shi, Di Wu, Junsong Chen, Ying Zhang, Fengsu Zhao and Jun Dou

    Citation: Cancer Cell International 2015 15:24

    Content type: Primary research

    Published on:

  4. Germline mutations in the von Hippel-Lindau (VHL) tumor suppressor gene predispose individuals to clear cell renal carcinomas, hemangioblastomas, and pheochromocytomas. The VHL gene product forms an ubiquitin ...

    Authors: Alana Doonachar, Michael D Gallo, Donald Doukas, Rajiv Pasricha, Igor Lantsberg and Alan R Schoenfeld

    Citation: Cancer Cell International 2015 15:23

    Content type: Primary research

    Published on:

  5. In many respects, the most remarkable chemical substances within the genome of eukaryotic cells are remarkable proteins which are the critical structural and functional units of living cells. The specification...

    Authors: Omar S Hajjawi

    Citation: Cancer Cell International 2015 15:22

    Content type: Review

    Published on:

  6. PPP2R2C encodes a gamma isoform of the regulatory subunit B55 subfamily consisting PP2A heterotrimeric with A and C subunits. Currently, the precise functions of B55gamma in cancer are still under investigatin...

    Authors: Ya-nan Li, Yi-qun Cao, Xi Wu, Guo-sheng Han, Lai-xing Wang, Yu-hui Zhang, Xin Chen, Bin Hao, Zhi-jian Yue and Jian-min Liu

    Citation: Cancer Cell International 2015 15:21

    Content type: Primary research

    Published on:

  7. The objective of this study was to determine the in vitro tumor-inhibitory effect of a recombinant adenovirus expressing a fusion protein of tumor necrosis factor (TNF) related apoptosis inducing ligand (TRAIL...

    Authors: Dongxiao Dong, Jing Gao, Ying Sun, Yuqing Long, Meng Li, Dongchao Zhang, Jianfang Gong, Liang Xu, Liuan Li, Shunyi Qin, Jifei Ma and Tianming Jin

    Citation: Cancer Cell International 2015 15:20

    Content type: Primary research

    Published on:

  8. Aerobic glycolysis rate is higher in breast cancer tissues than adjacent normal tissues which providethe ATP, lactate and anabolic precursors required for tumourgenesis and metastasis. Lactate dehydrogenase (L...

    Authors: Abdolhassan Talaiezadeh, Ali Shahriari, Mohammad Reza Tabandeh, Payam Fathizadeh and Siavash Mansouri

    Citation: Cancer Cell International 2015 15:19

    Content type: Primary research

    Published on:

  9. Psoriasin (S100A7) plays a role in the malignant potential of several epithelial cancers, and could candidate diagnostic marker or therapeutic target. Nuclear factor kappa B (NF-κB) regulates cancer cell growt...

    Authors: Guijuan Liu, Qiang Wu, Guilan Liu, Xueying Song and Jihong Zhang

    Citation: Cancer Cell International 2015 15:18

    Content type: Primary research

    Published on:

    The Retraction Note to this article has been published in Cancer Cell International 2016 16:40

  10. Angiogenesis is a critical step of breast cancer metastasis. Oncogenic Ras promotes the remodeling of cancer microenviroment. Tumor-associated macrophages (TAMs) are a prominent inflammatory cell population em...

    Authors: Wei Li, Rong-Rui Liang, Chong Zhou, Meng-Yao Wu, Lian Lian, Gao-Feng Yuan, Ming-Yun Wang, Xin Xie, Liu-Mei Shou, Fei-Ran Gong, Kai Chen, Wei-Ming Duan and Min Tao

    Citation: Cancer Cell International 2015 15:17

    Content type: Primary research

    Published on:

  11. Lung cancer is the leading cause of cancer-related morbidity and mortality all over the world. Surgery resection, radiotherapy, chemotherapy, immunotherapy and combined treatments have been discovered and well...

    Authors: Zhenkuan Liu and Shaoxiang Huang

    Citation: Cancer Cell International 2015 15:16

    Content type: Primary research

    Published on:

  12. Galangin (3,5,7-trihydroxyflavone) is a flavonoid compound found in high concentration in lesser galangal. The objective of this study was to investigate the ability of galangin to inhibit 12-O-tetradecanoylph...

    Authors: Shang-Tao Chien, Ming-Der Shi, Yi-Chieh Lee, Chou-Chia Te and Yuan-Wei Shih

    Citation: Cancer Cell International 2015 15:15

    Content type: Primary research

    Published on:

  13. Cells with homologous recombination (HR) deficiency, most notably caused by mutations in the BRCA1 or BRCA2 genes, are sensitive to PARP inhibition. Microsatellite instability (MSI) accounts for 10-15% of colorec...

    Authors: Sybil M Genther Williams, Apryle M Kuznicki, Paula Andrade, Brian M Dolinski, Cem Elbi, Ronan C O’Hagan and Carlo Toniatti

    Citation: Cancer Cell International 2015 15:14

    Content type: Primary research

    Published on:

  14. Cholangiocarcinoma (CCA) is an aggressive disease with limited effective treatment options. The PI3K/Akt/mTOR pathway represents an attractive therapeutic target due to its frequent dysregulation in CCA. MK220...

    Authors: Jacob M Wilson, Selvi Kunnimalaiyaan, Muthusamy Kunnimalaiyaan and T Clark Gamblin

    Citation: Cancer Cell International 2015 15:13

    Content type: Primary research

    Published on:

  15. Malignant glioma is the most devastating and aggressive tumour in the brain and is characterised by high morbidity, high mortality and extremely poor prognosis. The main purpose of the present study was to inv...

    Authors: Qun Li, Xiang-he Lu, Cheng-de Wang, Lin Cai, Jiang-long Lu, Jin-sen Wu, Qi-chuan Zhuge, Wei-ming Zheng and Zhi-peng Su

    Citation: Cancer Cell International 2015 15:12

    Content type: Primary research

    Published on:

  16. To determine the effects of arsenic trioxide (ATO) and nilotinib (AMN107, Tasigna) alone or in combination on the proliferation and differentiation of primary leukemic cells from patients with chronic myeloid ...

    Authors: Wei Wang, Fei-fei Lv, Yan Du, Nannan Li, YaLing Chen and LiHong Chen

    Citation: Cancer Cell International 2015 15:10

    Content type: Primary research

    Published on:

  17. Recepteur d’origine nantais (RON) is a receptor tyrosine kinase whose overexpression has been observed in human gastric cancers. This study aimed to determine whether overexpression of the variant RONΔ160 coul...

    Authors: Dong-Hui Zhou, Chao Li and Li-Na Yang

    Citation: Cancer Cell International 2015 15:9

    Content type: Primary research

    Published on:

  18. In previous study we showed that caspase-2 plays the role of an apical caspase in cell death induction by taxanes in breast cancer cells. This study deals with the role of other caspases. We tested breast canc...

    Authors: Michael Jelínek, Kamila Balušíková, Martina Schmiedlová, Vlasta Němcová-Fürstová, Jan Šrámek, Jitka Stančíková, Ilaria Zanardi, Iwao Ojima and Jan Kovář

    Citation: Cancer Cell International 2015 15:8

    Content type: Primary research

    Published on:

  19. Cisplatin (CIS) is one of the most effective anticancer drug used in the treatment of several solid tumors .Its use is limited by its nephrotoxicity. The present study was designed to assess the role of a natu...

    Authors: Abdel-Moneim M Osman, Saud A Telity, Zoheir A Damanhouri, Sameer E Al-Harthy, Huda M Al-Kreathy, Wafaa S Ramadan, Mohamed F Elshal, Lateef M Khan and Fatemah Kamel

    Citation: Cancer Cell International 2015 15:6

    Content type: Primary research

    Published on:

    The Correction to this article has been published in Cancer Cell International 2019 19:30

  20. Evasion of apoptosis is a hallmark of cancer cells. One mechanism to deregulate the apoptotic pathway is by upregulation of the anti-apoptotic Bcl-2 family members. Navitoclax (ABT-263) is a Bcl-2/Bcl-xL inhibito...

    Authors: Lloyd T Lam, Haichao Zhang, John Xue, Joel D Leverson and Anahita Bhathena

    Citation: Cancer Cell International 2015 15:5

    Content type: Primary research

    Published on:

  21. BIX-01294, an euchromatic histone-lysine N-methyltransferase 2 (EHMT2) inhibitor, has been reported to induce apoptosis in human neuroblastoma cells and inhibit the proliferation of bladder cancer cells. Howev...

    Authors: Jing Cui, Wendong Sun, Xuexi Hao, Minli Wei, Xiaonan Su, Yajing Zhang, Ling Su and Xiangguo Liu

    Citation: Cancer Cell International 2015 15:4

    Content type: Primary research

    Published on:

  22. An area of research that has been recently gaining attention is the relationship between cancer stem cell (CSC) biology and chemo-resistance in colon cancer patients. It is well recognized that tumor initiatio...

    Authors: Elsa N Garza-Treviño, Salvador L Said-Fernández and Herminia G Martínez-Rodríguez

    Citation: Cancer Cell International 2015 15:2

    Content type: Review

    Published on:

  23. Tumour cells show greater dependency on glycolysis so providing a sufficient and rapid energy supply for fast growth. In many breast cancers, estrogen, progesterone and epidermal growth factor receptor-positiv...

    Authors: Simon Taylor, Matthew Lam, Chathyan Pararasa, James EP Brown, Amtul R Carmichael and Helen R Griffiths

    Citation: Cancer Cell International 2015 15:1

    Content type: Review

    Published on:

  24. There is limited information on a special subtype of Acute myeloid leukemia (AML) characterized by >20% myeloblasts and >20% abnormal promyelocytes in bone marrow and peripheral blood.

    Authors: GanLin He, ChunYan Wang, QingEn Li, Huo Tan, FuXiong Chen, ZhenQian Huang, BaoDan Yu, LiXia Zheng, RunHui Zheng and Dan Liu

    Citation: Cancer Cell International 2014 14:111

    Content type: Primary research

    Published on:

  25. T cell-mediated immunity plays an important role in enhancing antitumor response.This study aimed to investigate the changes in the T-lymphocyte subpopulation and to characterize the differential expression pa...

    Authors: Qingsong Yin, Lin Chen, Qianyu Li, Ruihua Mi, Yufu Li, Xudong Wei and Yongping Song

    Citation: Cancer Cell International 2014 14:85

    Content type: Primary research

    Published on:

  26. Recent studies suggested that leptin as a mitogenic factor might play an important role in the process of initiation and progression of human cancer. Therefore, it could be considered as a target for breast ca...

    Authors: Kazem Nejati-Koshki, Abolfazl Akbarzadeh and Mohammad Pourhassan-Moghaddam

    Citation: Cancer Cell International 2014 14:66

    Content type: Primary research

    Published on:

  27. Recently a sub-population of cells with stem cell characteristics, reported to be associated with initiation, growth, spread and recurrence, has been identified in several solid tumors including oral tongue sq...

    Authors: Saira Saleem, Arif Jamshed, Saima Faisal, Raza Hussain, Muhammad Tahseen, Asif Loya and Chris Sutton

    Citation: Cancer Cell International 2014 14:542

    Content type: Primary research

    Published on:

  28. A key strategy for the study of the tumor microenvironment is to implant human tumor cells in an immunodeficient rodent strain ubiquitously expressing a fluorescent marker. Here, a novel nude rat expressing a ...

    Authors: Ning Yang, Bin Huang, Oleg Tsinkalovsky, Narve Brekkå, Huaiyang Zhu, Lina Leiss, Per Øyvind Enger, Xingang Li and Jian Wang

    Citation: Cancer Cell International 2014 14:541

    Content type: Primary research

    Published on:

  29. Several signal transduction pathways have been reported being involved in the acquisition of P-glycoprotein (P-gp) mediated multi-drug resistance (MDR) upon exposure to anti-cancer drugs, whereas there is evid...

    Authors: Feifei Xu, Fengliang Wang, Ting Yang, Yuan Sheng, Ting Zhong and Yun Chen

    Citation: Cancer Cell International 2014 14:538

    Content type: Primary research

    Published on:

  30. Endometrial carcinoma is one of the most common gynecologic malignancies. Estrogen plays a critical role in its pathogenesis, but the underlying mechanism is not clear. Nucleophosmin 1 (NPM1), a multifunctiona...

    Authors: Yunxiao Zhou, Jie Shen, Liqun Xia and Yanli Wang

    Citation: Cancer Cell International 2014 14:540

    Content type: Primary research

    Published on:

  31. Photodynamic therapy (PDT) is becoming a promising therapeutic modality for hematological malignancies. Hypericin is a natural photosensitizer possessing anti-depressant, anti-virus and anti-cancer activities....

    Authors: Junping Zhang, Linxiang Shao, Chunlin Wu, Hongfei Lu and Ruian Xu

    Citation: Cancer Cell International 2014 14:136

    Content type: Primary research

    Published on:

  32. Photodynamic therapy (PDT) is becoming a promising therapeutic modality for hematological malignancies. Hypericin is a natural photosensitizer possessing anti-depressant...

    Authors: Junping Zhang, Linxiang Shao, Chunlin Wu, Hongfei Lu and Ruian Xu

    Citation: Cancer Cell International 2014 15:58

    Content type: Primary research

    Published on:

    The Retraction Note to this article has been published in Cancer Cell International 2015 15:66

  33. To evaluate the balance between T-cell immunoglobulin and mucin domain (Tim) molecules(Tim)-1 and Tim-3 in patients with aplastic anemia (AA), plasma IFN-γ and IL-4 levels were measured in patients with active...

    Authors: Xin Liu, Xin Cui, Dai Yuan, Ying Li, Ning-ning Shan, Xin Wang and Yu Hu

    Citation: Cancer Cell International 2014 14:144

    Content type: Primary research

    Published on:

  34. H2AX is phosphorylated (γH2AX) by members of the phosphatidylinositol 3-kinase (PI3K) family, including Ataxia telangiectasia-mutated (ATM), ATM- and Rad3-related (ATR) and DNA-PK in response to DNA damage. Ou...

    Authors: Zhong Guo, Jin Zhao, Lei Song, Jian-Xiu Ma, Chen-Jing Wang, Shu-Yan Pei, Chao Jiang and Shang-Biao Li

    Citation: Cancer Cell International 2014 14:141

    Content type: Primary research

    Published on:

  35. Both microRNA (miR)-196a and miR-196b are implicated in normal cell differentiation, proliferation, and in tumorigenesis of various cancer types. Especially, miR-196a exerts a pro-oncogenic influence in colore...

    Authors: Jie Ge, Zihua Chen, Ruixing Li, Tailiang Lu and Guangfa Xiao

    Citation: Cancer Cell International 2014 14:128

    Content type: Primary research

    Published on:

  36. Esophageal squamous cell carcinoma (ESCC) is one of the most common and deadly forms of cancer. Despite advances in the diagnosis and treatment of this cancer, the survival rate at five years is poor. Lately, ...

    Authors: Chao Yang, Siqing Ning, Zhaoyuan Li, Xiaomin Qin and Wei Xu

    Citation: Cancer Cell International 2014 14:138

    Content type: Primary research

    Published on:

  37. Epidermal growth factor (EGF) plays a pivotal role in cell proliferation, differentiation, and tumorigenesis of epithelial tissues. Variation of the EGF +61A/G (rs4444903) can lead to an alteration in EGF prod...

    Authors: Qiliu Peng, Shan Li, Xue Qin, Xianjun Lao, Zhiping Chen, Xiaolian Zhang and Junqiang Chen

    Citation: Cancer Cell International 2014 14:134

    Content type: Primary research

    Published on:

  38. Multiple myeloma is a hematologic malignancy characterized by the accumulation of monoclonal plasma cells in the bone marrow. A common manifestation of the disease is myeloma bone disease (MBD), which is cause...

    Authors: Rong Fu, Hui Liu, Sijie Zhao, Yihao Wang, Lijuan Li, Shan Gao, Erbao Ruan, Guojin Wang, Huaquan Wang, Jia Song and Zonghong Shao

    Citation: Cancer Cell International 2014 14:132

    Content type: Primary research

    Published on:

  39. This study provided additional data on the effects of a therapeutic electromagnetic field (EMF) device on growth and vascularization of murine 16/C mammary adenocarcinoma cells implanted in C3H/HeJ mice.

    Authors: Ivan L Cameron, Marko S Markov and W Elaine Hardman

    Citation: Cancer Cell International 2014 14:125

    Content type: Primary research

    Published on:

  40. Treatment with imatinib mesylate (IM) (a tyrosine kinase inhibitor) is the first line of standard care for patients newly diagnosed with CML. Despite the success of IM and other tyrosine kinase inhibitors (TKI...

    Authors: Changshu Cao, Bailian Liu, Chengwu Zeng, Yuhong Lu, Shaohua Chen, Lijian Yang, Bo Li, Yaolan Li and Yangqiu Li

    Citation: Cancer Cell International 2014 14:137

    Content type: Primary research

    Published on:

  41. Persistent infection of Mycoplasma hyorhinis (M. hyorhinis) was associated with gastric cancer cell migration and invasion, but the mechanisms were not well understood. Herein, we found that M. hyorhinis activate...

    Authors: Hongying Duan, Like Qu and Chengchao Shou

    Citation: Cancer Cell International 2014 14:135

    Content type: Primary research

    Published on:

  42. Burkitt’s lymphoma is an aggressive malignancy with high risk of metastasis to extranodal sites, such as bone marrow and central nervous system. The prognosis of metastatic Burkitt’s lymphoma is poor. Here we ...

    Authors: Ning Ding, Lingyan Ping, Lixia Feng, Xiaohui Zheng, Yuqin Song and Jun Zhu

    Citation: Cancer Cell International 2014 14:2

    Content type: Primary research

    Published on:

  43. Cell cycle regulatory pathway is a well-established pathway mainly dependent on cyclin-dependent kinases (CDKs), which are regulated positively by cyclins and negatively by cyclin-dependent kinase inhibitors(C...

    Authors: Xiangming He, Hua Xiang, Xiangyun Zong, Xuebing Yan, Yang Yu, Guan Liu, Dehong Zou and Hongjian Yang

    Citation: Cancer Cell International 2014 14:130

    Content type: Primary research

    Published on:

  44. Concurrent study of secretomic and glycoproteomic profiles in cancer cell lines represents an excellent approach for investigating cancer progression and identifying novel biomarker candidates. In this study, ...

    Authors: Aik-Aun Tan, Alan Kang-Wai Mu, Lik-Voon Kiew and Yeng Chen

    Citation: Cancer Cell International 2014 14:120

    Content type: Primary research

    Published on:

  45. According to contemporary epidemiological and experimental evidence, we propose a novel classification of cancers based on pathogenesis instead of classifications based on histological appearance of cancer. Th...

    Authors: Carlos Sonnenschein, Barbara Davis and Ana M Soto

    Citation: Cancer Cell International 2014 14:113

    Content type: Review

    Published on:

  46. Erlotinib is a novel therapeutic agent for cancer treatment. This study was performed to investigate the role of c-MET-PI3K-AKT pathway in the regulation of erlotinib-induced radiosensitization.

    Authors: Hong-Qing Zhuang, Hongxia Zhuang, Qifu Bo, Yihang Guo, Jun Wang, Lu-Jun Zhao, Zhi-Yong Yuan and Ping Wang

    Citation: Cancer Cell International 2014 14:109

    Content type: Primary research

    Published on:

Annual Journal Metrics

Institutional membership

Visit the membership page to check if your institution is a member and learn how you could save on article-processing charges (APCs).

Funding your APC

​​​​​​​Open access funding and policy support by SpringerOpen​​

​​​​We offer a free open access support service to make it easier for you to discover and apply for article-processing charge (APC) funding. Learn more here