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  1. Previous studies have found that the microenvironment of cervical cancer (CESC) affects the progression and treatment of this disease. Thus, we constructed a multigene model to assess the survival of patients ...

    Authors: Qian Chen, Bingqing Qiu, Xiaoyun Zeng, Lang Hu, Dongping Huang, Kaihua Chen and Xiaoqiang Qiu
    Citation: Cancer Cell International 2021 21:182
  2. Lung adenocarcinoma (LUAD) is one of the most common malignancies worldwide. However, the molecular mechanism of LUAD tumorigenesis and development remains unclear. The purpose of this study was to comprehensi...

    Authors: Guoshu Bi, Donglin Zhu, Yunyi Bian, Yiwei Huang, Cheng Zhan, Yong Yang and Qun Wang
    Citation: Cancer Cell International 2021 21:181
  3. Long noncoding RNAs (lncRNAs) have recently identified as essential gene modulators in numerous cancers. Previous studies have confirmed the oncogenic role of long intergenic nonprotein-coding RNA 00514 (LINC0...

    Authors: Xiao Luo and Hui Wang
    Citation: Cancer Cell International 2021 21:180

    The Correction to this article has been published in Cancer Cell International 2021 21:561

  4. Studies have discussed long noncoding RNA DDX11-AS1 (DDX11-AS1)-mediated downstream mechanism in hepatocellular carcinoma (HCC). The goal of this study was to investigate the regulatory mechanism of DDX11-AS1-...

    Authors: Gangqiang Ding, Yanli Zeng, Dongqiang Yang, Can Zhang, Chongshan Mao, Erhui Xiao, Yi Kang and Jia Shang
    Citation: Cancer Cell International 2021 21:179

    The Correction to this article has been published in Cancer Cell International 2021 21:659

  5. Aberrantly expressed microRNAs play important roles in gastric tumorigenesis. However, use of miRNAs as a therapeutic option in gastric cancer still remains as a challenging problem.

    Authors: Narjes Jafari, Saeid Abediankenari and Hadi Hossein-Nataj
    Citation: Cancer Cell International 2021 21:178
  6. Chemo-resistance is still a major obstacle in leukemia treatment. Accumulating evidence indicates that cancer-associated fibroblasts (CAFs), the most abundant stromal cells in tumor microenvironment (TME), pla...

    Authors: Yuanyuan Li and Ling Gu
    Citation: Cancer Cell International 2021 21:177
  7. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Zhao‑liang Yu, Yu‑feng Chen, Bin Zheng, Ze-rong Cai, Yi‑feng Zou, Jia Ke, Ping Lan, Feng Gao and Xiao‑jian Wu
    Citation: Cancer Cell International 2021 21:176

    The original article was published in Cancer Cell International 2021 21:94

  8. Transcription factors (TFs) may be engaged in reciprocal regulatory circuits with certain miRNAs to maintain cellular homeostasis. Disequilibrium of the reciprocities by certain tumor-related stimuli may give ...

    Authors: Wenjing Zhang, Haitao Yang, Zhongqiu Wang, Yanting Wu, Jingzhai Wang, Guihua Duan, Qiang Guo and Yu Zhang
    Citation: Cancer Cell International 2021 21:175
  9. The incidence and mortality rates of hepatocellular carcinoma are among the highest of all cancers all over the world. However the survival rates are relatively low due to lack of effective treatments. Efforts...

    Authors: Fan Zhang, Mengjuan Xue, Xin Jiang, Huiyuan Yu, Yixuan Qiu, Jiaming Yu, Fan Yang and Zhijun Bao
    Citation: Cancer Cell International 2021 21:174
  10. Gastric intestinal metaplasia (GIM) is a significant risk factor for gastric cancer. Risk of gastric cancer/dysplasia between complete intestinal metaplasia (CIM) and incomplete intestinal metaplasia (IIM) was...

    Authors: Ning Wei, Mengyue Zhou, Siyu Lei, Zhiheng Zhong and Ruihua Shi
    Citation: Cancer Cell International 2021 21:173
  11. As a tissue-specific proangiogenic or antiangiogenic agent, angiopoietin-like 4 (ANGPTL4) has recently gained attention in many diseases, such as metabolic syndrome, cardiovascular disease and cancer. However,...

    Authors: Yuxian Wu, Jinghai Gao and Xiaojun Liu
    Citation: Cancer Cell International 2021 21:171
  12. Neuroblastoma is a childhood neural crest tumor showing large clinical and genetic heterogeneity, one form displaying 11q-deletion is very aggressive. It has been shown that 11q-deletion results in decreased e...

    Authors: Simon Keane, Tommy Martinsson, Per Kogner and Katarina Ejeskär
    Citation: Cancer Cell International 2021 21:170
  13. Nowadays, colorectal cancer (CRC) is one of the most commonly diagnosed malignant tumors worldwide, the incidence rate of which is still increasing year by year. Herein, the objective of this study is to inves...

    Authors: Qiang Feng, Dongkui Xu, Mingyao Zhou, Zijian Wu, Zhiyuan Wu, Zheng Wang, Jianjun Bi and Wei Pei
    Citation: Cancer Cell International 2021 21:169
  14. Long non-coding RNA (lncRNA) has been confirmed to exert a critical effect on the progression of tumors, including prostate cancer. Previous literature has demonstrated LINC01116 involves in activities of mult...

    Authors: Shengjie Yu, Huihong Yu, Yuanfeng Zhang, Chuan Liu, Weili Zhang and Yunyun Zhang
    Citation: Cancer Cell International 2021 21:168
  15. Head and neck squamous cell carcinoma (HNSCC) is a common tumor worldwide with poor prognosis. The pathogenesis of human papillomavirus (HPV)-positive and HPV-negative HNSCCs differs. However, few studies have...

    Authors: Guocai Tian, You Fu, Dahe Zhang, Jiang Li, Zhiyuan Zhang and Xi Yang
    Citation: Cancer Cell International 2021 21:167

    The Correction to this article has been published in Cancer Cell International 2021 21:248

  16. Tumor metastasis is one of the leading reasons of the dismal prognosis of hepatocellular carcinoma (HCC). Epithelial-mesenchymal transition (EMT) is closely associated with tumor metastasis including HCC. The ...

    Authors: Gongmin Zhu, Hongwei Xia, Qiulin Tang and Feng Bi
    Citation: Cancer Cell International 2021 21:166
  17. Radiotherapy is a major treatment for esophageal squamous cell carcinoma (ESCC). However, HPV infection related radioresistance caused poor prognosis of ESCC. The function of SOCS6, which has been shown to be ...

    Authors: Xuanzi Sun, Yuchen Sun, Jing Li, Xu Zhao, Xiaobo Shi, Tuotuo Gong, Shupei Pan, Zhongqiang Zheng and Xiaozhi Zhang
    Citation: Cancer Cell International 2021 21:165
  18. Numerous individual studies have investigated the diagnostic value of EBV-DNA, EA-IgA, VCA-IgA, EBNA1-IgA and Rta-IgG detection for nasopharyngeal carcinoma (NPC), but the conclusions remain controversial. Thi...

    Authors: Weixing Liu, Gui Chen, Xin Gong, Yingqi Wang, Yaoming Zheng, Xiao Liao, Wenjing Liao, Lijuan Song, Jun Xu and Xiaowen Zhang
    Citation: Cancer Cell International 2021 21:164
  19. Slug (Snai2) is a pivotal player in initiating epithelial-mesenchymal transition (EMT) through its trans-suppression effect on E-cadherin in various normal and malignant cells. In this study, the positive effe...

    Authors: Xian Liu, Qian Feng, Yanru Zhang, PengSheng Zheng and Nan Cui
    Citation: Cancer Cell International 2021 21:163
  20. Patients with type 2 diabetes mellitus (T2DM) have an increased risk of suffering from various malignancies. This study aimed to identify specific biomarkers that can detect lung adenocarcinoma (LAC) in T2DM p...

    Authors: Jiayue Yang, Cheng Yang, Hong Shen, Wenjun Wu, Zhen Tian, Qinghua Xu, Cuiping Cao, Shugao Ye, Le Ban, Xin Tong and Jie Mei
    Citation: Cancer Cell International 2021 21:162
  21. Cholangiocarcinoma (CCA) is the second most common primary liver malignancy worldwide. Several microRNAs (miRNAs) have been implicated as potential tumor suppressors in CCA. This study aims to explore the pote...

    Authors: Xin Pan, Gang Wang and Baoming Wang
    Citation: Cancer Cell International 2021 21:161
  22. CDC27 is one of the core components of Anaphase Promoting complex/cyclosome. The main role of this protein is defined at cellular division to control cell cycle transitions. Here we review the molecular aspect...

    Authors: Golnaz Ensieh Kazemi-Sefat, Mohammad Keramatipour, Saeed Talebi, Kaveh Kavousi, Roya Sajed, Nazanin Atieh Kazemi-Sefat and Kazem Mousavizadeh
    Citation: Cancer Cell International 2021 21:160
  23. Human cell division cycle associated 8 (CDCA8) a key regulator of mitosis, has been described as a potential prognostic biomarker for a variety of cancers, such as breast, colon and lung cancers. We aimed to eval...

    Authors: Yu Shuai, Erxi Fan, Qiuyue Zhong, Qiying Chen, Guangyong Feng, Xiaoxia Gou and Guihai Zhang
    Citation: Cancer Cell International 2021 21:159
  24. A crosstalk established between tumor microenvironment and tumor cells leads to contribution or inhibition of tumor progression. Mesenchymal stem cells (MSCs) are critical cells that fundamentally participate ...

    Authors: Surendar Aravindhan, Sura Salman Ejam, Methaq Hadi Lafta, Alexander Markov, Alexei Valerievich Yumashev and Majid Ahmadi
    Citation: Cancer Cell International 2021 21:158
  25. Uterine leiomyosarcoma (ULMS) is a malignant tumor found in the smooth muscle lining the walls of the uterus. Cancer stem cells (CSCs) are responsible for metastasis, drug resistance, and relapse of cancer, re...

    Authors: Jiuping Gao, Ting Yang, Xu Wang, Yi Zhang, Jing Wang, Beilei Zhang, Dihong Tang, Yanqiong Liu, Ting Gao, Qiuhui Lin, Jun Tang and Jingting Cai
    Citation: Cancer Cell International 2021 21:157
  26. Esophageal squamous cell carcinoma (ESCC) is one of the most malignant tumors in gastrointestinal system. MicroRNAs (miRNAs) have been reported to be implicated in cancer development. However, the role of miR-...

    Authors: Shuwen Xu, Xiaofeng Li, Longfei Li, Yufeng Wang, Chong Geng, Feng Guo, Tao Zhang, Aonan Du, Zhiwei Lu, Hua Hui and Qiang Wang
    Citation: Cancer Cell International 2021 21:155
  27. Globally, gastrointestinal (GI) cancer is one of the most prevalent malignant tumors. However, studies have not established glycolysis-related gene signatures that can be used to construct accurate prognostic ...

    Authors: Rong Xia, Hua Tang, Jiemiao Shen, Shuyu Xu, Yinyin Liang, Yuxin Zhang, Xing Gong, Yue Min, Di Zhang, Chenzhe Tao, Shoulin Wang, Yi Zhang, Jinyou Yang and Chao Wang
    Citation: Cancer Cell International 2021 21:154
  28. Circular RNAs (circRNAs) have been reported to play vital roles in colorectal cancer (CRC). However, only a few circRNAs have been experimentally validated and functionally described. In this research, we aime...

    Authors: Lanlan Xi, Quanlin Liu, Wei Zhang, Linshan Luo, Jingfeng Song, Ruitao Liu, Shue Wei and Yong Wang
    Citation: Cancer Cell International 2021 21:153
  29. CircRNAs with tissue-specific expression and stable structure may be good tumor prognostic markers. However, the expression of circRNAs in esophageal squamous cell carcinoma (ESCC) remain unknown. We aim to id...

    Authors: Weiwei Wang, Di Zhu, Zhihua Zhao, Miaomiao Sun, Feng Wang, Wencai Li, Jianying Zhang and Guozhong Jiang
    Citation: Cancer Cell International 2021 21:151
  30. Accumulating evidences have been reported that long noncoding RNAs play crucial roles in the progression of hepatocellular carcinoma (HCC). SnoRNA host gene 6 (SNHG6) is believed to be involved in several huma...

    Authors: Xiaoxi Fan, Zhongwei Zhao, Jingjing Song, Dengke Zhang, Fazong Wu, Jianfei Tu, Min Xu and Jiansong Ji
    Citation: Cancer Cell International 2021 21:150
  31. Transmembrane protein with EGF-like and two follistatin-like domains 2 (TMEFF2) is a transmembrane protein in the tomoregulin family. Little research has been performed to determine whether TMEFF2 methylation ...

    Authors: Sidi Xie, Yunxiao Zhang, Tao Peng, Jinglin Guo, Yongfu Cao, Jing Guo, Xiaofeng Shi, Yaqin Li, Yawei Liu, Songtao Qi and Hai Wang
    Citation: Cancer Cell International 2021 21:148
  32. Tongue squamous cell carcinoma (TSCC) is one of the most common oral tumors. Recently, long intergenic noncoding RNA 00958 (LINC00958) has been identified as an oncogene in human cancers. Nevertheless, the rol...

    Authors: Bo Jia, Junfeng Dao, Jiusong Han, Zhijie Huang, Xiang Sun, Xianghuai Zheng, Shijian Xiang, Huixi Zhou and Shuguang Liu
    Citation: Cancer Cell International 2021 21:147
  33. Pien Tze Huang (PZH) is a well-known Traditional Chinese Medicine (TCM), characterized by a multitude of pharmacological effects, such as hepatoprotection and inhibition of inflammation and cell proliferative ...

    Authors: Zhiliang Chen
    Citation: Cancer Cell International 2021 21:146
  34. Emerging evidence continues to highlight the significant role of microRNAs (miRNAs) in the regulation of cancer growth and metastasis. Herein, the current study aimed to elucidate the role of exosomal miR-183 ...

    Authors: Yanping Dai and Xiaoqin Gao
    Citation: Cancer Cell International 2021 21:145
  35. TUBA1C is a microtubule component that is involved in a variety of cancers. Our main objective was to investigate TUBA1C expression, its prognostic value, its potential biological functions, and its impact on ...

    Authors: Tingting Bian, Miaosen Zheng, Daishan Jiang, Jian Liu, Hui Sun, Xiaoli Li, Lei Liu, Jianguo Zhang and Yifei Liu
    Citation: Cancer Cell International 2021 21:144
  36. Long non-coding RNAs (lncRNAs) have been reported to exert crucial functions in regulating the progression of human cancers. However, the function and mechanism of long intergenic non-protein coding RNA 01089 ...

    Authors: Huixian Zhang, Hao Zhang, Xingya Li, Siyuan Huang, Qianqian Guo and Di Geng
    Citation: Cancer Cell International 2021 21:143
  37. Invasive malignant pleomorphic adenoma (IMPA) is a highly invasive parotid gland tumor and lacks effective therapy. N6-Methyladenosine (m6A) is the most prevalent post-transcriptional modification of mRNAs in euk...

    Authors: Zhenyuan Han, Biao Yang, Qin Wang, Yuhua Hu, Yuqiong Wu and Zhen Tian
    Citation: Cancer Cell International 2021 21:142
  38. Diffuse large B-cell lymphoma (DLBCL) is a common type of the Non-Hodgkin lymphomas (NHLs) formed by the neoplastic transformation of mature B cells. As the first-line therapeutics, CHOP (cyclophosphamide/doxo...

    Authors: Yu Zhang, Jingjing Xiang, Xianfu Sheng, Ni Zhu, Shu Deng, Junfa Chen, Lihong Yu, Yan Zhou, Chenjun Lin and Jianping Shen
    Citation: Cancer Cell International 2021 21:141
  39. Cell division cycle-associated 7 (CDCA7), as a member of the cell division cycle associated family, was reported to be aberrantly expressed in both solid tumors and hematological tumors, suggesting its essenti...

    Authors: Shouyong Liu, Yi Wang, Chenkui Miao, Qianwei Xing and Zengjun Wang
    Citation: Cancer Cell International 2021 21:140
  40. Gastric cancer (GC) is considered one of the most lethal malignancies worldwide, which is accompanied by a poor prognosis. Although reports regarding the importance of cancer stem cell (CSC) markers in gastric...

    Authors: Mahdieh Razmi, Roya Ghods, Somayeh Vafaei, Maryam Sahlolbei, Leili Saeednejad Zanjani and Zahra Madjd
    Citation: Cancer Cell International 2021 21:139
  41. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Jingxian Liu, Jinghong Yang, Yuhe Hou, Zhenwei Zhu, Jie He, Hao Zhao, Xidong Ye, Dengke Li, Zhaohui Wu, Zhongxi Huang, Bingtao Hao and Kaitai Yao
    Citation: Cancer Cell International 2021 21:138

    The original article was published in Cancer Cell International 2019 19:348

  42. Emerging evidence has shown that intra-tumor immune features are associated with response to immune checkpoint blockade (ICB) therapy. Accordingly, patient stratification is needed for identifying target patie...

    Authors: Jingkai Liu, Qiaofei Liu, Xiang Zhang, Ming Cui, Tong Li, Yalu Zhang and Quan Liao
    Citation: Cancer Cell International 2021 21:137
  43. Pemetrexed, a new generation antifolate drug, has been approved for the treatment of locally advanced or metastatic breast cancer. However, factors affecting its efficacy and resistance have not been fully elu...

    Authors: Jihui Chen, Zhipeng Wang, Shouhong Gao, Kejin Wu, Fang Bai, Qiqiang Zhang, Hongyu Wang, Qin Ye, Fengjing Xu, Hong Sun, Yunshu Lu and Yan Liu
    Citation: Cancer Cell International 2021 21:136

    The Correction to this article has been published in Cancer Cell International 2021 21:183

  44. The anti-epidermal growth factor receptor (EGFR) antibody introduces adaptable variations to the transcriptome and triggers tumor immune infiltration, resulting in colorectal cancer (CRC) treatment resistance....

    Authors: Li Liang, Mengling Liu, Xun Sun, Yitao Yuan, Ke Peng, Khalid Rashid, Yiyi Yu, Yuehong Cui, Yanjie Chen and Tianshu Liu
    Citation: Cancer Cell International 2021 21:135
  45. Esophageal cancer is associated with high incidence and mortality worldwide. Differential expression genes (DEGs) and weighted gene co-expression network analysis (WGCNA) are important methods to screen the co...

    Authors: Rui Wu, Hao Zhuang, Yu-Kun Mei, Jin-Yu Sun, Tao Dong, Li-Li Zhao, Zhi-Ning Fan and Li Liu
    Citation: Cancer Cell International 2021 21:134
  46. Circular RNAs (circRNAs) have been demonstrated to play significant roles in regulating gene expression in tumorigenesis, including breast cancer (BC). This study was designed to explore the role and underlyin...

    Authors: Liqiang Qi, Bo Sun, Beibei Yang and Su Lu
    Citation: Cancer Cell International 2021 21:133

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