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  1. Despite the modern therapies available for treating glioblastoma multiforme (GBM), it is still a deadly disease. The development of new therapeutic strategies for the management of gliomas is therefore crucial...

    Authors: Farina Hanif, Kahkashan Perveen, Huma Jawed, Aqeel Ahmed, Saima M Malhi, Siddiqua Jamall and Shabana U Simjee

    Citation: Cancer Cell International 2014 14:133

    Content type: Primary research

    Published on:

  2. Epithelial mesenchymal transition (EMT) is thought to be an essential feature of malignant tumor cells when they spread into the stroma. Despite the extracellular acidity of tumor tissues, the effect of acidic...

    Authors: Atsuko Suzuki, Toyonobu Maeda, Yuh Baba, Kazuhiro Shimamura and Yasumasa Kato

    Citation: Cancer Cell International 2014 14:129

    Content type: Primary research

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  3. The null genotype of GSTM1 have been implicated in gastric cancer risk, but numerous individual studies showed mixed, or even conflicting results. Thus, a meta-analysis was performed.

    Authors: Xianjun Lao, Qiliu Peng, Yu Lu, Shan Li, Xue Qin, Zhiping Chen and Junqiang Chen

    Citation: Cancer Cell International 2014 14:127

    Content type: Primary research

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  4. The mechanism underlying the differential cytotoxicity of curcumin in various cancer types, however, remains largely unclear. The aims of this study is to examine the concentration- and time-related effects of...

    Authors: Tao Jia, Li Zhang, Yale Duan, Min Zhang, Gang Wang, Jun Zhang and Zheng Zhao

    Citation: Cancer Cell International 2014 14:126

    Content type: Primary research

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  5. The inevitable side effects of the currently used chemotherapy are associated with serious syndromes. Genotoxic effects and consequent genetic instability may play an important role in these syndromes. The aim...

    Authors: Nasir Kamat, Mohammed A Khidhir, Sabir Hussain, Mouied M Alashari and Ulf Rannug

    Citation: Cancer Cell International 2014 14:118

    Content type: Primary research

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  6. Accumulating studies have focused on the oncogenic and tumor suppressive roles of the newly identified lncRNAs. A novel lncRNA BC040587 in 3q13.31 locus which exists frequent copy number alterations was found ...

    Authors: Yayun Chi, Sheng Huang, Lin Yuan, Mengying Liu, Naisi Huang, Shuling Zhou, Bingqing Zhou and Jiong Wu

    Citation: Cancer Cell International 2014 14:123

    Content type: Primary research

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  7. Tumour homing capacity of engineered human adipose-derived mesenchymal stromal cells (ADMSCs) expressing anti-tumour agents might be the key for a much safer and yet efficient targeted tumour therapy. However,...

    Authors: Kamal Shaik Fakiruddin, Puteri Baharuddin, Moon Nian Lim, Noor Atiqah Fakharuzi, Nurul Ain Nasim M Yusof and Zubaidah Zakaria

    Citation: Cancer Cell International 2014 14:122

    Content type: Primary research

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  8. MicroRNAs (miRNA) are small non-coding RNAs that play an important role in the control of gene expression by inhibiting protein translation or promoting messenger RNA degradation. Today, miRNAs have been shown...

    Authors: Denis R Morais, Sabrina T Reis, Nayara Viana, Camila Berfort Piantino, Cristina Massoco, Caio Moura, Nelson Dip, Iran A Silva, Miguel Srougi and Katia RM Leite

    Citation: Cancer Cell International 2014 14:119

    Content type: Primary research

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  9. Non-B cell immunoglobulins (Igs) are widely expressed in epithelial cancer cells. The past 20 years of research have demonstrated that non-B cell Igs are associated with cancer cell proliferation, the cellular...

    Authors: Lina Wu, Yang Liu, Xiaohui Zhu, Li Zhang, Jinfeng Chen, Hong Zhang, Peng Hao, Shuai Zhang, Jing Huang, Jie Zheng, Yingmei Zhang, Youhui Zhang and Xiaoyan Qiu

    Citation: Cancer Cell International 2014 14:114

    Content type: Primary research

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  10. Suberoylanilide hydroxamic acid (SAHA) is a member of the hydroxamic acid class of the newly developed histone deacetylase inhibitors. Recently, Suberoylanilide hydroxamic acid has attracted increasing attenti...

    Authors: Zhaohui Liu, Ying Tong, Yuanlin Liu, Huaping Liu, Chundong Li, Yue Zhao and Yi Zhang

    Citation: Cancer Cell International 2014 14:112

    Content type: Primary research

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  11. Epiregulin (EPR) is a novel member of the epidermal growth factor (EGF) family. It has been shown to promote wound healing in oral epithelium, enhance proliferation of other epithelial tissues, and is involved...

    Authors: Darren Chyi-Hsiang Kong, Kenneth Yee Choy Chew, Eng Lai Tan and Suan Phaik Khoo

    Citation: Cancer Cell International 2014 14:65

    Content type: Primary research

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  12. MicroRNAs are small non-coding RNAs that play crucial roles in the pathogenesis of different cancer types. The aim of this study was to identify miRNAs that are differentially expressed in endometrial adenocar...

    Authors: Sanja Jurcevic, Björn Olsson and Karin Klinga-Levan

    Citation: Cancer Cell International 2014 14:88

    Content type: Primary research

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  13. Undifferentiated embryonic cell transcription factor-1 (UTF1) plays a critical role in the developmental timing during embryonic development. However, there is little paper dealing with UTF1 expressed in adult...

    Authors: Chaoyang Xu, Ying Zhou and Wei Chen

    Citation: Cancer Cell International 2014 14:116

    Content type: Primary research

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  14. The US National Cancer Institute (NCI) and the National Human Genome Research Institute (NHGRI) created the Cancer Genome Atlas (TCGA) Project in 2006. The TCGA’s goal was to sequence the genomes of 10,000 tum...

    Authors: Shengwen Calvin Li, Lisa May Ling Tachiki, Mustafa H Kabeer, Brent A Dethlefs, Michael J Anthony and William G Loudon

    Citation: Cancer Cell International 2014 14:115

    Content type: Review

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  15. Suberoyl bis-hydroxamic acid (SBHA) is a histone deacetylase (HDAC) inhibitor and exerts anti-growth effects in several malignancies including breast cancer. Proteasome inhibitors such as Bortezomib and MG-132...

    Authors: Xinmiao Yang, Zeliang Shi, Ning Zhang, Zhouluo Ou, Shen Fu, Xichun Hu and Zhenzhou Shen

    Citation: Cancer Cell International 2014 14:107

    Content type: Primary research

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  16. Growth factor mediated activation of RAS-MAP-kinase and PI3-kinase-AKT pathways are critical for the pathogenesis of glioblastoma. The attenuation of PI3-kinase/AKT signaling will be effective in regulating th...

    Authors: Alok R Singh, Shweta Joshi, Elizabeth George and Donald L Durden

    Citation: Cancer Cell International 2014 14:105

    Content type: Primary research

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  17. The cancer microenvironment has a strong impact on the growth and dynamics of cancer cells. Conventional 2D culture systems, however, do not reflect in vivo conditions, impeding detailed studies of cancer cell dy...

    Authors: Laura P Ivers, Brendan Cummings, Funke Owolabi, Katarzyna Welzel, Rut Klinger, Sayaka Saitoh, Darran O’Connor, Yasuyuki Fujita, Dimitri Scholz and Nobue Itasaki

    Citation: Cancer Cell International 2014 14:108

    Content type: Primary research

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  18. Ursolic acid (UA), a plant extract used in traditional Chinese medicine, exhibits potential anticancer effects in various human cancer cell lines in vitro. In the present study, we evaluated the anti-tumoral prop...

    Authors: Hao Weng, Zhu-Jun Tan, Yun-Ping Hu, Yi-Jun Shu, Run-Fa Bao, Lin Jiang, Xiang-Song Wu, Mao-Lan Li, Qian Ding, Xu-an Wang, Shan-shan Xiang, Huai-Feng Li, Yang Cao, Feng Tao and Ying-Bin Liu

    Citation: Cancer Cell International 2014 14:96

    Content type: Primary research

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  19. Chemotherapy for advanced cholangiocarcinoma (CCA) is largely ineffective, but innovative combinations of chemotherapeutic agents and natural compounds represent a promising strategy. In our previous studies, ...

    Authors: Chariya Hahnvajanawong, Wareeporn Wattanawongdon, Chariya Chomvarin, Natthinee Anantachoke, Sakawrat Kanthawong, Banchob Sripa and Vichai Reutrakul

    Citation: Cancer Cell International 2014 14:68

    Content type: Primary research

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  20. Interleukin (IL)-23 is one of the newly identified inflammatory cytokines, and inflammation is also known to be related to the development of gastric cancer (GC). The role of IL-23 in gastric cancer, however, ...

    Authors: Changming Liu, Ying Zhang, Jie Zhan, Yuanyuan Zhao, Qijun Wan, Huiping Peng and Wei Zhu

    Citation: Cancer Cell International 2014 14:104

    Content type: Primary research

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  21. Mechanical loads can regulate cell proliferation and differentiation at various stages of development and homeostasis. However, the extension of this regulatory effect of mechanical loads on cancer cells is la...

    Authors: Melis Olcum and Engin Ozcivici

    Citation: Cancer Cell International 2014 14:102

    Content type: Primary research

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  22. Chemotherapy either before or after surgery is a common breast cancer treatment. Long-term, high dose treatments with chemotherapeutic drugs often result in undesirable side effects, frequent recurrences and r...

    Authors: Shan Wu, Jinsong Guo, Wendong Wei, Jue Zhang, Jing Fang and Stephen J Beebe

    Citation: Cancer Cell International 2014 14:98

    Content type: Primary research

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  23. Hepatocellular carcinoma (HCC) is a highly aggressive and heterogeneous disease. HCC cell lines established from different patients would be useful in elucidating the molecular pathogenesis. However, success o...

    Authors: Phyllis Fung-Yi Cheung, Chi Wai Yip, Linda Wing-Chi Ng, Kwok Wai Lo, Nathalie Wong, Kwong Wai Choy, Chit Chow, Kui Fat Chan, Tan To Cheung, Ronnie Tung-Ping Poon, Sheung Tat Fan and Siu Tim Cheung

    Citation: Cancer Cell International 2014 14:103

    Content type: Primary research

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  24. Side population (SP) assay identifies cells with dye/drug extrusion ability, a characteristic of stem cells. Here, we determined if SP cells exist in a verified cell line originating from recurrent nasopharyng...

    Authors: Susan Ling Ling Hoe, Lu Ping Tan, Juliana Jamal, Suat Cheng Peh, Ching Ching Ng, Wen Cai Zhang, Munirah Ahmad and Alan Soo Beng Khoo

    Citation: Cancer Cell International 2014 14:101

    Content type: Primary research

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  25. Matrix metalloproteinase-2 (MMP-2) is an endopeptidase that facilitates extracellular matrix remodeling and molecular regulation, and is implicated in tumor metastasis. Type I collagen (Col I) regulates the ac...

    Authors: Kulrut Borrirukwanit, Prasit Pavasant, Tony Blick, Marc A Lafleur and Erik W Thompson

    Citation: Cancer Cell International 2014 14:99

    Content type: Primary research

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  26. Natural killer (NK) cells eliminate virus-infected and tumor cells through the release of perforins and granzymes; they also produce Interferon gamma (IFN-γ) and Tumor necrosis factor alpha (TNF-γ), which indu...

    Authors: Paulina Gómez-Lomelí, Alejandro Bravo-Cuellar, Georgina Hernández-Flores, Luis Felipe Jave-Suárez, Adriana Aguilar-Lemarroy, José Manuel Lerma-Díaz, Jorge Ramiro Domínguez-Rodríguez, Karina Sánchez-Reyes and Pablo Cesar Ortiz-Lazareno

    Citation: Cancer Cell International 2014 14:100

    Content type: Primary research

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  27. Hypoxia inducible factor 1α (HIF-1α) is a stress-responsive transcription factor to hypoxia and its expression is correlated to tumor progression and angiogenesis. Several single nucleotide polymorphisms (SNPs...

    Authors: Chih-Jen Huang, Shi-Long Lian, Ming-Feng Hou, Chee-Yin Chai, Yi-Hsing Yang, Sheng-Fung Lin and Hsueh-Wei Chang

    Citation: Cancer Cell International 2014 14:87

    Content type: Primary research

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  28. In response to antigen naive CD8+, T cells differentiate into effector cells, which express Natural killer (NK) receptors, lose CD28 expression, and die by apoptosis. However, in smaller quantities, the cells ...

    Authors: Maria Luisa Pita-Lopez, Pablo Cesar Ortiz-Lazareno, Monica Navarro-Meza, Felipe Santoyo-Telles and Oscar Peralta-Zaragoza

    Citation: Cancer Cell International 2014 14:97

    Content type: Primary research

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  29. Human umbilical cord blood derived-mesenchymal stem cells (hUCMSCs) offer an attractive alternative to bone marrow-derived MSCs (BMMSCs) for cell-based therapy as it is a less invasive source of biological mat...

    Authors: Xiaoya Yang, Zhu Li, Yintu Ma, Jun Gao, Surui Liu, Yuhua Gao and Gengyin Wang

    Citation: Cancer Cell International 2014 14:93

    Content type: Primary research

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  30. Up-regulation of the PI3K/mTOR (phosphatidylinositol-3′ kinase/mammalian target of rapamycin) signaling is common in carcinoma. Consistently, targeting these molecules has been shown to halt the growth of many...

    Authors: Alia Albawardi, Muna Al Ayyan, Mohamed Al Bashir, Abdul-Kader Souid and Saeeda Almarzooqi

    Citation: Cancer Cell International 2014 14:90

    Content type: Primary research

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  31. Many studies support that chemokine (C-X-C motif) ligand 1 (CXCL1) regulate tumor epithelial-stromal interactions involving in tumor growth and invasion. However, limited studies have been conducted on the exp...

    Authors: Zhongwei Cao, Biao Fu, Biao Deng, Yue Zeng, Xinjian Wan and Lei Qu

    Citation: Cancer Cell International 2014 14:86

    Content type: Primary research

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  32. Aberrant microRNA (miRNA) expression plays an essential role in the pathogenesis of Hepatocellular Carcinoma (HCC). However, specific involvement of miRNAs in HCC remains incompletely understood. The aim of th...

    Authors: Jianxin Jiang, Yi Zhang, Chao Yu, Zhipeng Li, Yaozheng Pan and Chengyi Sun

    Citation: Cancer Cell International 2014 14:95

    Content type: Primary research

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  33. Five cell lines were established from a Singaporean patient of Chinese origin with breast ductal carcinoma in situ (DCIS). These five cell lines express exogenous human telomerase reverse transcriptase (hTERT)...

    Authors: Jacklyn WY Yong, Meng Ling Choong, SiFang Wang, Yu Wang, Shermaine QY Lim and May Ann Lee

    Citation: Cancer Cell International 2014 14:94

    Content type: Primary research

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  34. Oncolytic herpes simplex virus (HSV) can replicate in and kill cancer cells while sparing the adjacent normal tissue. Hepatocellular carcinoma (HCC) is amongst the most common and lethal cancers, especially in...

    Authors: Jiani Wang, Lihua Xu, Weigen Zeng, Pan Hu, Musheng Zeng, Samuel D Rabkin and Renbin Liu

    Citation: Cancer Cell International 2014 14:83

    Content type: Primary research

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  35. Transforming growth factor beta (TGF-β) plays major roles in tumorigenesis by regulating cell growth, epithelial-to-mesenchymal transition (EMT), migration/invasion and metastasis. The epithelial markers E-cad...

    Authors: Jingfang Gao, Yihong Zhu, Mikael Nilsson and Karin Sundfeldt

    Citation: Cancer Cell International 2014 14:72

    Content type: Primary research

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  36. Published data on the association between AURKA polymorphisms and breast cancer (BC) risk are inconclusive. This meta-analysis was performed to derive a more precise estimation on the relationship between AURK...

    Authors: Zhi-Jun Dai, Hua-Feng Kang, Xi-Jing Wang, Yong-Ping Shao, Shuai Lin, Yang Zhao, Hong-Tao Ren, Wei-Li Min, Meng Wang and Xiao-Xu Liu

    Citation: Cancer Cell International 2014 14:91

    Content type: Primary research

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  37. Platelet-derived growth factors (PDGFs) bind to two receptors, PDGFRα and PDGFRα to mediate cell proliferation, migration and survival. Although epithelial cells typically do not express high levels of PDGFRs,...

    Authors: Leanne Stalker, James Pemberton and Roger A Moorehead

    Citation: Cancer Cell International 2014 14:89

    Content type: Primary research

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  38. Ribavirin is an anti-viral drug; however, recent data suggest that it may also be effective in cancer therapy. This study investigated the effect of ribavirin alone or in combination with IFN-α on biological p...

    Authors: Lichen Teng, Dexin Ding, Yongsheng Chen, Hongshuang Dai, Guobin Liu, Zhongjie Qiao and Ruihua An

    Citation: Cancer Cell International 2014 14:63

    Content type: Primary research

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  39. Head and neck squamous cell carcinoma (HNSCC) is characterized by aggressive loco-regional invasion. Sphingosine kinase1 (SphK1), an enzyme in sphingolipid metabolism, is emerging as a key player in HNSCC path...

    Authors: Paulette M Tamashiro, Hideki Furuya, Yoshiko Shimizu and Toshihiko Kawamori

    Citation: Cancer Cell International 2014 14:76

    Content type: Primary research

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  40. There is a strong interest in the investigation of extremely low frequency Electromagnetic Fields (EMF) in the clinic. While evidence about anticancer effects exists, the mechanism explaining this effect is st...

    Authors: Nenad Filipovic, Tijana Djukic, Milos Radovic, Danijela Cvetkovic, Milena Curcic, Snezana Markovic, Aleksandar Peulic and Branislav Jeremic

    Citation: Cancer Cell International 2014 14:84

    Content type: Primary research

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  41. The molecular heterogeneity of high-grade astrocytomas underlies the difficulties in the development of representative and valuable in vitro experimental models for their studies.

    Authors: Monika Witusik-Perkowska, Magdalena Zakrzewska, Malgorzata Szybka, Wielislaw Papierz, Dariusz J Jaskolski, Pawel P Liberski and Beata Sikorska

    Citation: Cancer Cell International 2014 14:82

    Content type: Primary research

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  42. Serum microRNAs (miRNAs) are a novel class of diagnostic and prognostic biomarkers for numerous cancers. However, the level and clinical relevance of circulating miR-205 transcripts in human serum of cervical ...

    Authors: Quanhui Ma, Guiping Wan, Shuxia Wang, Wanwei Yang, Jiaming Zhang and Xiaoming Yao

    Citation: Cancer Cell International 2014 14:81

    Content type: Primary research

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  43. Aberrant DNA methylation is an acquired epigenetic alteration that serves as an alternative to genetic defects in the inactivation of tumor suppressor genes and other genes in diverse human cancers. Gastric ca...

    Authors: Yinguo Bai, Na Fang, Tingxun Gu, Yuhua Kang, Jiang Wu, Desheng Yang, Hui Zhang, Zhimin Suo and Shaoping Ji

    Citation: Cancer Cell International 2014 14:79

    Content type: Primary research

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  44. Survivin is a protein that is normally present only in G2 and M-phases in somatic cells, however, in cancer cells, it is expressed throughout the cell cycle. A prosurvival factor, survivin is both an inhibitor...

    Authors: Aysha M Aljaberi, Jamie RM Webster and Sally P Wheatley

    Citation: Cancer Cell International 2014 14:78

    Content type: Primary research

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  45. Bone destruction and abnormal immunity always occur in patients with multiple myeloma (MM), which manifested by impaired osteoblasts and immune system. In this study, we investigated the quantity and function ...

    Authors: Rong Fu, Shan Gao, Fengping Peng, Jing Li, Hui Liu, Huaquan Wang, Linmin Xing and Zonghong Shao

    Citation: Cancer Cell International 2014 14:62

    Content type: Primary research

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  46. Cancer cells, even in the presence of available oxygen, have a glycolysis enhancement. The “aerobic glycolysis” is known as the Warburg effect and it is considered one of the fundamental hallmarks of metabolic...

    Authors: Luca Bruni, Adesola A Babarinde, Ida Ortalli and Simonetta Croci

    Citation: Cancer Cell International 2014 14:77

    Content type: Primary research

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  47. The small molecule NSC676914A was previously identified as an NF-κB inhibitor in TPA-stimulated HEK293 cells (Mol Can Ther 8:571-581, 2009). We hypothesized that this effect would also be seen in ovarian cance...

    Authors: Ethan Sagher, Lidia Hernandez, Callee Heywood, Gary T Pauly, Matthew R Young, Joel Schneider, Nancy H Colburn and Christina M Annunziata

    Citation: Cancer Cell International 2014 14:75

    Content type: Primary research

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