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  1. Recent studies have suggested that the metastasis-associated colon cancer1 (MACC1) gene can promote tumor proliferation, invasion and metastasis through an upregulation of c-Met expression. However, its role i...

    Authors: Tiankang Guo, Jingyu Yang, Jibin Yao, Yongbin Zhang, Mingxu Da and Yaoxing Duan

    Citation: Cancer Cell International 2013 13:121

    Content type: Primary research

    Published on:

  2. Bladder cancer is a relatively common and potentially life-threatening neoplasm that ranks ninth in terms of worldwide cancer incidence. The aim of this study was to determine deletions and sequence variations...

    Authors: Nasser Shakhssalim, Massoud Houshmand, Behnam Kamalidehghan, Abolfazl Faraji, Reza Sarhangnejad, Sepideh Dadgar, Maryam Mobaraki, Rozita Rosli and Mohammad Hossein Sanati

    Citation: Cancer Cell International 2013 13:120

    Content type: Primary research

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  3. The initiation and progression of various solid tumors, including pancreatic carcinoma, are driven by a population of cells with stem cell properties, namely cancer stem cells (CSCs). Like their normal counter...

    Authors: Haitao Zhu, Dongqing Wang, Yanfang Liu, Zhaoliang Su, Lirong Zhang, Fangfang Chen, Yuepeng Zhou, Yingying Wu, Ming Yu, Zhijian Zhang and Genbao Shao

    Citation: Cancer Cell International 2013 13:119

    Content type: Primary research

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  4. The mechanisms responsible for cervical cancer radioresistance are still largely unexplored. The present study aimed to identify miRNAs associated with radioresistance of cervical cancer cells.

    Authors: Bin Zhang, Jun Chen, Zhenghua Ren, Yongbin Chen, Jinhui Li, Xia Miao, Yang Song, Tao Zhao, Yurong Li, Yongquan Shi, Dongqing Ren and Junye Liu

    Citation: Cancer Cell International 2013 13:118

    Content type: Primary research

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  5. Chronic myeloid leukemia is a clonal myeloproliferative disorder disease in which BCR/ABL plays an important role as an oncoprotein and molecular target. Despite the success of targeted therapy using tyrosine ...

    Authors: Guoqiang Chang, Hongju Zhang, Jian Wang, Yujuan Zhang, Hua Xu, Chijuan Wang, Hairui Zhang, Li Ma, Qinghua Li and Tianxiang Pang

    Citation: Cancer Cell International 2013 13:117

    Content type: Primary research

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  6. The apoptosis-stimulating protein of p53 (ASPP) family comprises three members, namely, ASPP1, ASPP2, and iASPP. They regulate the promotive effect of p53 on apoptosis. Breast cancer (BC) remains as one of the...

    Authors: Changsong Wang, Chunfang Gao, Yanping Chen, Jian Yin, Ping Wang and Xuexia Lv

    Citation: Cancer Cell International 2013 13:116

    Content type: Primary research

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  7. Lung cancer is the leading cause of cancer-related death in the world, with metastasis as the main reason for the mortality. CELF1 is an RNA-binding protein controlling the post-transcriptional regulation of g...

    Authors: Li-Na Wu, Yi-Jun Xue, Li-Jian Zhang, Xue-Mei Ma and Jin-Feng Chen

    Citation: Cancer Cell International 2013 13:115

    Content type: Primary research

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  8. Although studies have shown the oncogene WT1 is overexpressed in lung cancer, there is no data showing the implication of WT1 in lung cancer biology. In the present study, we first demonstrated that isotype C ...

    Authors: Xi Wang, Ping Gao, Fang Lin, Min Long, Yuanyuan Weng, Yongri Ouyang, Li Liu, Junxia Wei, Xi Chen, Ting He, Huizhong Zhang and Ke Dong

    Citation: Cancer Cell International 2013 13:114

    Content type: Primary research

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  9. Increasing evidence suggest that ubiquitin-proteasome system (UPS) plays a key role in tumorigenesis. HERC4 is a recently identified ubiqutin ligase. However, the expression status and biological functions of ...

    Authors: Hui Zhou, Rong Shi, Min Wei, Wen-Ling Zheng, Jue-Yu Zhou and Wen-Li Ma

    Citation: Cancer Cell International 2013 13:113

    Content type: Primary research

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  10. To investigate the effect of the H-2Kd gene on the lymphocyte membrane, we constructed a small interfering RNA (siRNA) that targets the H-2Kd gene and compared the cytotoxicity of mouse lymphokine-activated kille...

    Authors: Xin Liu, Xin Cui, Ningning Shan, Ying Li, Xiaosheng Fang, Mei Ding and Xin Wang

    Citation: Cancer Cell International 2013 13:112

    Content type: Primary research

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  11. Convincing evidence indicates that statins stimulate apoptotic cell death in several types of proliferating tumor cells in a cholesterol-lowering-independent manner. However, the relationship between apoptosis...

    Authors: Xu-Feng Qi, Dong-Heui Kim, Kyu-Jae Lee, Cheol-Su Kim, Soon-Bong Song, Dong-Qing Cai and Soo-Ki Kim

    Citation: Cancer Cell International 2013 13:111

    Content type: Primary research

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  12. Leukemia is the most common malignant proliferative disease in children. Our previous study found that miR-99a was up-regulated in pediatric primary AML using microRNA expression profiles. Up to date, although...

    Authors: Lidan Zhang, Xiaojuan Li, Zhiyong Ke, Libin Huang, Yanni Liang, Jun Wu, Xiaoli Zhang, Yueqin Chen, Hua Zhang and Xuequn Luo

    Citation: Cancer Cell International 2013 13:110

    Content type: Primary research

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  13. The transcription factor SOX11 is one of members of the SRY box-containing (SOX) family emerging as important transcriptional regulators. In recent years, up-regulation of SOX11 has been detected in various ty...

    Authors: Song Zhang, Shuo Li and Jin-Liang Gao

    Citation: Cancer Cell International 2013 13:109

    Content type: Primary research

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  14. Lup-20(29)-en-3H-ol (Lupeol), a dietary triterpene, has been shown to possess multiple pharmacological activities including anti-tumor effects

    Authors: Fen Liu, Yan He, Yong Liang, Lijun Wen, Yongming Zhu, Yan Wu, Lixiang Zhao, Yunsen Li, Xinliang Mao and Haiyan Liu

    Citation: Cancer Cell International 2013 13:108

    Content type: Primary research

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  15. Folypolyglutamate synthase (FPGS) catalyzes the polyglutamation of folates and antifolates, such as methotrexate (MTX), to produce highly active metabolites. FPGS tag SNP rs1544105C > T is located in the gene pro...

    Authors: Shu-Guang Liu, Chao Gao, Rui-Dong Zhang, Ying Jiao, Lei Cui, Wei-Jing Li, Zhen-Ping Chen, Min-Yuan Wu, Hu-Yong Zheng, Xiao-Xi Zhao, Zhi-Xia Yue and Zhi-Gang Li

    Citation: Cancer Cell International 2013 13:107

    Content type: Primary research

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  16. Recent studies indicated that a synthetic oligonucleotide containing un-methylated CpG oligodeoxynucleotides (CpG-ODN) has a potential function for cancer therapy. In this study, we evaluated the chemosensitiz...

    Authors: Sheng-ran Liang, Guang-rui Hu, Li-juan Fang, Su-jing Huang, Jin-song Li, Ming-yi Zhao and Min-jie Meng

    Citation: Cancer Cell International 2013 13:106

    Content type: Primary research

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  17. Taxol (generic name paclitaxel), a plant-derived antineoplastic agent, used widely against breast, ovarian and lung cancer, was originally isolated from the bark of the Pacific yew, Taxus brevifolia. The limited ...

    Authors: Balabhadrapatruni VSK Chakravarthi, Ramanathan Sujay, Gini C Kuriakose, Anjali A Karande and Chelliah Jayabaskaran

    Citation: Cancer Cell International 2013 13:105

    Content type: Primary research

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  18. MicroRNAs (miRNAs) are small, non-coding RNAs that can function as oncogenes or tumor suppressors in human cancer. Abnormally expressed miR-224 was found to play a fundamental role in several types of cancer. ...

    Authors: Guang-jun Zhang, He Zhou, Hua-xu Xiao, Yu Li and Tong Zhou

    Citation: Cancer Cell International 2013 13:104

    Content type: Primary research

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  19. The altered expression of prolactin (PRL) and its receptor (PRLR) has been implicated in breast and other types of cancer. There are few studies that have focused on the analysis of PRL/PRLR in cervical cancer...

    Authors: Edgar I Lopez-Pulido, José F Muñoz-Valle, Susana Del Toro-Arreola, Luis F Jave-Suárez, Miriam R Bueno-Topete, Ciro Estrada-Chávez and Ana Laura Pereira-Suárez

    Citation: Cancer Cell International 2013 13:103

    Content type: Primary research

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  20. Plant-based compounds have been in the spotlight in search of new and promising drugs. Flavokawain A, B and C are naturally occurring chalcones that have been isolated from several medicinal plants; namely the pi...

    Authors: Nadiah Abu, Wan Yong Ho, Swee Keong Yeap, M Nadeem Akhtar, Mohd Puad Abdullah, Abdul Rahman Omar and Noorjahan Banu Alitheen

    Citation: Cancer Cell International 2013 13:102

    Content type: Review

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  21. Homeobox (HOX) genes deregulation has been largely implicated in the development of human leukemia. Among the HOXB cluster, HOXB1 was silent in a number of analyzed acute myeloid leukemia (AML) primary cells a...

    Authors: Marina Petrini, Federica Felicetti, Lisabianca Bottero, Maria Cristina Errico, Ornella Morsilli, Alessandra Boe, Alessandra De Feo and Alessandra Carè

    Citation: Cancer Cell International 2013 13:101

    Content type: Primary research

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  22. The associations between the polymorphisms of interleukin-8 (IL-8) gene and gastric carcinogenesis have been extensively investigated in recent years. However, the results remain conflicting rather than conclu...

    Authors: Daye Cheng, Yiwen Hao, Wenling Zhou and Yiran Ma

    Citation: Cancer Cell International 2013 13:100

    Content type: Primary research

    Published on:

  23. The incidence and mortality associated with intrahepatic cholangiocarcinoma is increasing in many countries and documentation of disease outcome is sparse. The present study was undertaken to investigate the p...

    Authors: Rui-qing Liu, Shu-jing Shen, Xiu-feng Hu, Jie Liu, Li-juan Chen and Xing-ya Li

    Citation: Cancer Cell International 2013 13:99

    Content type: Primary research

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  24. Recent evidence suggests that vascular endothelial growth factor-C (VEGF-C)- dependent tumour production promotes lymphangiogenesis, while membrane-type matrix 1 metalloproteinase (MT1-MMP) is involved in the ...

    Authors: Guangyu Yao, Ping He, Lujia Chen, Xiaolei Hu, Fan Gu and Changsheng Ye

    Citation: Cancer Cell International 2013 13:98

    Content type: Primary research

    Published on:

  25. Human epidermal growth factor receptor-2 (Her-2) is over expressed in approximately 25-30% of all primary breast tumors resulting in a distinctive breast cancer subtype associated with a poor prognosis and a d...

    Authors: Tracey Hurrell and Kim Outhoff

    Citation: Cancer Cell International 2013 13:97

    Content type: Primary research

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  26. MicroRNAs are a class of endogenous single strand non-coding RNAs that are involved in many important physiological and pathological processes. The purpose of this study was to examine the expression levels of...

    Authors: Qifeng Luo, Xiaoyu Li, Yan Gao, Yin Long, Lei Chen, Yixiang Huang and Lin Fang

    Citation: Cancer Cell International 2013 13:95

    Content type: Primary research

    Published on:

  27. Angiogenesis represents a highly multi-factorial and multi-cellular complex (patho-) physiologic event involving endothelial cells, tumor cells in malignant conditions, as well as bone marrow derived cells and...

    Authors: Melanie Hein and Shannon Graver

    Citation: Cancer Cell International 2013 13:94

    Content type: Primary research

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  28. Somatostatin receptors (SSTRs) and opioid receptors (ORs) belong to the superfamily of G-protein coupled receptors and function as negative regulators of cell proliferation in breast cancer. In the present stu...

    Authors: Geetanjali Kharmate, Padmesh S Rajput, Yu-Chen Lin and Ujendra Kumar

    Citation: Cancer Cell International 2013 13:93

    Content type: Primary research

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  29. Ras association domain family 1A gene (RASSFlA) is a candidate suppressor gene, Lack of RASSF1A expression was found in lung cancer. High DNA methylation at the promoter region is the main reason for inactivat...

    Authors: Duan Mengxi, Wang Qian, Wang Nan, Xiao Xiaoguang and Li Shijun

    Citation: Cancer Cell International 2013 13:91

    Content type: Primary research

    Published on:

  30. Our recent evidence showed that Toll like receptor 9 (TLR9) signaling could enhance the growth and metastatic potential of human lung cancer cells through repressing microRNA-7 (miR-7) expression. Human antige...

    Authors: Yong-Ju Li, Chun-Hong Wang, Ya Zhou, Zheng-Yuan Liao, Shun-Fei Zhu, Yan Hu, Chao Chen, Jun-Min Luo, Zhen-Ke Wen and Lin Xu

    Citation: Cancer Cell International 2013 13:90

    Content type: Primary research

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  31. Acidic extracellular pH is a major feature of tumor tissue, extracellular acidification being primarily considered to be due to lactate secretion from anaerobic glycolysis. Clinicopathological evidence shows t...

    Authors: Yasumasa Kato, Shigeyuki Ozawa, Chihiro Miyamoto, Yojiro Maehata, Atsuko Suzuki, Toyonobu Maeda and Yuh Baba

    Citation: Cancer Cell International 2013 13:89

    Content type: Review

    Published on:

  32. The multiple tyrosine kinase inhibitors SU6668 have a promising therapeutic effect on the progression of hematological malignancies and some solid tumors. Here, we determined its effect on triple negative brea...

    Authors: Lu Wang, Zhaozhe Liu, Dongchu Ma, Ying Piao, Fang Guo, Yaling Han and Xiaodong Xie

    Citation: Cancer Cell International 2013 13:88

    Content type: Primary research

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  33. 2-Methoxyestradiol has been shown to induce both autophagy and apoptosis in various carcinogenic cell lines. Although a promising anti-cancer agent, it has poor bioavailability and rapid in vivo metabolism which ...

    Authors: Anne E Theron, Elsie M Nolte, Laurence Lafanechère and Annie M Joubert

    Citation: Cancer Cell International 2013 13:87

    Content type: Primary research

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  34. Despite advances in detection and therapy, epithelial ovarian cancer (EOC) still represents the most lethal gynecologic malignancy in women worldwide. The high mortality of EOC is mainly due to late-stage diag...

    Authors: Ying Chen, Lei Zhang and Quan Hao

    Citation: Cancer Cell International 2013 13:86

    Content type: Review

    Published on:

  35. Glioblastoma stem-like cells (GSC) have been shown to promote tumor growth, tumor-associated neovascularization, therapeutic resistance, and metastasis. CXCR4 receptors have been found involved in the prolifer...

    Authors: Chin-Cheng Lee, Jin-Huei Lai, Dueng-Yang Hueng, Hsin-I Ma, Yuan- Chiang Chung, Ya-yun Sun, Yih-Ju Tsai, Wen-Ben Wu and Chih-Li Chen

    Citation: Cancer Cell International 2013 13:85

    Content type: Primary research

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  36. The prognosis of oral squamous cell carcinoma is very poor due to local recurrence and metastasis. This study explores the molecular events involved in oral carcinoma with the goal of developing novel therapeu...

    Authors: Bin Zhang, Ke Yi Li, Hai Ying Chen, Shao Dong Pan, Li Cheng Jiang, Ya Ping Wu and Shu Wei Liu

    Citation: Cancer Cell International 2013 13:83

    Content type: Primary research

    Published on:

  37. It has been shown that proteasome inhibition leads to growth arrest in the G1 phase of the cell cycle and/or induction of apoptosis. However, it was found that some of these inhibitors do not induce apoptosis ...

    Authors: Khaled Y Orabi, Mohamed S Abaza, Khalid A El Sayed, Ahmed Y Elnagar, Rajaa Al-Attiyah and Radhika P Guleri

    Citation: Cancer Cell International 2013 13:82

    Content type: Primary research

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  38. B7-H3 and matrix metalloproteinases 2 (MMP-2) are reported highly expressed in malignant tumor, we investigate the relationship between B7-H3 expression and MMP-2 on malignant behavior and prognosis predictabl...

    Authors: Lihua Xu, Xiangmin Ding, Huo Tan and Jianjun Qian

    Citation: Cancer Cell International 2013 13:81

    Content type: Primary research

    Published on:

  39. Citation: Cancer Cell International 2013 13:80

    Content type: Erratum

    Published on:

    The original article was published in Cancer Cell International 2012 12:2

  40. The human “Elston and Ellis grading method” was utilized in dogs with mammary tumor to examine its relation to prognosis in this species, based on a 2-year follow-up period. Although cytopathology is widely us...

    Authors: Radmehr Shafiee, Javad Javanbakht, Nahid Atyabi, Pegah Kheradmand, Danial Kheradmand, Alimohammad Bahrami, Hasti Daraei and Farshid Khadivar

    Citation: Cancer Cell International 2013 13:469

    Content type: Primary research

    Published on:

    The Retraction Note to this article has been published in Cancer Cell International 2016 16:83

  41. Recent evidence suggests a subset of cells within a tumor with "stem-like" characteristics. These cells are able to transplant tumors in immunodeficient hosts. Distinct from non-malignant stem cells, cancer st...

    Authors: Rüdiger M Zimmerer, Philippe Korn, Philippe Demougin, Andreas Kampmann, Horst Kokemüller, André M Eckardt, Nils-Claudius Gellrich and Frank Tavassol

    Citation: Cancer Cell International 2013 13:78

    Content type: Primary research

    Published on:

  42. Taxol is a powerful chemotherapy agent leading to mitotic arrest and cell death; however, its clinical efficacy has been hampered due to the development of drug resistance. Taxol specifically targets the cell ...

    Authors: Xueqing Wang, Lingya Pan, Ning Mao, Lifang Sun, Xiangjuan Qin and Jie Yin

    Citation: Cancer Cell International 2013 13:77

    Content type: Primary research

    Published on:

  43. Epithelial-mesenchymal transition (EMT) is a process implicated in cancer metastasis that involves the conversion of epithelial cells to a more mesenchymal and invasive cell phenotype. In breast cancer cells E...

    Authors: Felicity M Davis, Michelle T Parsonage, Peter J Cabot, Marie-Odile Parat, Erik W Thompson, Sarah J Roberts-Thomson and Gregory R Monteith

    Citation: Cancer Cell International 2013 13:76

    Content type: Primary research

    Published on:

  44. One of the most popular and versatile model of murine melanoma is by inoculating B16 cells in the syngeneic C57BL6J mouse strain. A characterization of different B16 modified cell sub-lines will be of real pra...

    Authors: Corina Danciu, Alexandra Falamas, Cristina Dehelean, Codruta Soica, Heinfried Radeke, Lucian Barbu-Tudoran, Florina Bojin, Simona Cîntă Pînzaru and Melania F Munteanu

    Citation: Cancer Cell International 2013 13:75

    Content type: Primary research

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  45. Transforming growth factor beta (TGFβ) is transiently increased in the mammary gland during involution and by radiation. While TGFβ normally has a tumour suppressor role, prolonged exposure to TGFβ can induce ...

    Authors: Karen A Dunphy, Jae-Hong Seo, Daniel J Kim, Amy L Roberts, Luwei Tao, James DiRenzo, Amanda L Balboni, Giovanna M Crisi, Mary J Hagen, Thiruppavai Chandrasekaran, Kelly J Gauger, Sallie Smith Schneider and D Joseph Jerry

    Citation: Cancer Cell International 2013 13:74

    Content type: Primary research

    Published on:

  46. Volatile organic compounds (VOCs) emitted by human body offer a unique insight into biochemical processes ongoing in healthy and diseased human organisms. Unfortunately, in many cases their origin and metaboli...

    Authors: Paweł Mochalski, Andreas Sponring, Julian King, Karl Unterkofler, Jakob Troppmair and Anton Amann

    Citation: Cancer Cell International 2013 13:72

    Content type: Primary research

    Published on:

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